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Cited by 51Cardiovascular and exercise physiologySports Performance and TrainingExercise and Physiological Responses

Influence of training intensity on adaptations in acid/base transport proteins, muscle buffer capacity, and repeated-sprint ability in active men

McGinley, Cian, Bishop, David J.·2016·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00630.2016
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Abstract

McGinley C, Bishop DJ. Influence of training intensity on adaptations in acid/base transport proteins, muscle buffer capacity, and repeated-sprint ability in active men. J Appl Physiol 121: 1290–1305, 2016. First published October 14, 2016; doi: 10.1152/japplphysiol.00630.2016 .—This study measured the adaptive response to exercise training for each of the acid-base transport protein families, including providing isoform-specific evidence for the monocarboxylate transporter (MCT)1/4 chaperone protein basigin and for the electrogenic sodium-bicarbonate cotransporter (NBCe)1. We investigated whether 4 wk of work-matched, high-intensity interval training (HIIT), performed either just above the lactate threshold (HIITΔ20; n = 8), or close to peak aerobic power (HIITΔ90; n = 8), influenced adaptations in acid-base transport protein abundance, nonbicarbonate muscle buffer capacity (βm in vitro), and exercise capacity in active men. Training intensity did not discriminate between adaptations for most proteins measured, with abundance of MCT1, sodium/hydrogen exchanger (NHE) 1, NBCe1, carbonic anhydrase (CA) II, and CAXIV increasing after 4 wk, whereas there was little change in CAIII and CAIV abundance. βm in vitro also did not change. However, MCT4 protein content only increased for HIITΔ20 [effect size (ES): 1.06, 90% confidence limits × / ÷ 0.77], whereas basigin protein content only increased for HIITΔ90 (ES: 1.49, × / ÷ 1.42). Repeated-sprint ability (5 × 6-s sprints; 24 s passive rest) improved similarly for both groups. Power at the lactate threshold only improved for HIITΔ20 (ES: 0.49; 90% confidence limits ± 0.38), whereas peak O 2 uptake did not change for either group. Detraining was characterized by the loss of adaptations for all of the proteins measured and for repeated-sprint ability 6 wk after removing the stimulus of HIIT. In conclusion, 4 wk of HIIT induced improvements in each of the acid-base transport protein families, but, remarkably, a 40% difference in training intensity did not discriminate between most adaptations.

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  • RSA-based exercises are highly efficient for many sports, as they engage all three energy pathways even in low-volume training sessions.

    “More recent findings suggest that RSA-based exercises are highly efficient for many sports, as they engage all three energy pathways even in low-volume training sessions1,3,11,16.”

    From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [11]

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Authors
McGinley, C., & Bishop, D. J.
Affiliations
Victoria University (AU)
Corresponding author
McGinley, Cian
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2016-12-01
Volume
121
Issue
6
Pages
1290-1305
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00630.2016
OpenAlex
W2529871468
Cited by
51
References
103
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 1
FWCI
9.60
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Victoria University Research Repository (Victoria University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
high-intensity interval training, exercise intensity, repeated sprint ability, MCT1, MCT4, CD147, NHE1, carbonic anhydrase, exercise capacity, lactate threshold, detraining
MeSH terms
Adaptation, Physiological, Adult, Carrier Proteins, Exercise Test, Humans, Male, Muscle Proteins, Oxygen Consumption, Rest, Exercise, Muscle, Skeletal, Lactic Acid, Monocarboxylic Acid Transporters, Sodium-Bicarbonate Symporters, Young Adult

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