Effects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performance
Abstract
This study determined the effects of altering the H+ concentration during interval training, by ingesting NaHCO 3 (Alk-T) or a placebo (Pla-T), on changes in muscle buffer capacity (βm), endurance performance, and muscle metabolites. Pre- and posttraining peak O 2 uptake (V̇o 2 peak), lactate threshold (LT), and time to fatigue at 100% pretraining V̇o 2 peak intensity were assessed in 16 recreationally active women. Subjects were matched on the LT, were randomly placed into the Alk-T ( n = 8) or Pla-T ( n = 8) groups, and performed 8 wk (3 days/wk) of six to twelve 2-min cycle intervals at 140–170% of their LT, ingesting NaHCO 3 or a placebo before each training session (work matched between groups). Both groups had improvements in βm (19 vs. 9%; P < 0.05) and V̇o 2 peak (22 vs. 17%; P < 0.05) after the training period, with no differences between groups. There was a significant correlation between pretraining βm and percent change in βm ( r = −0.70, P < 0.05). There were greater improvements in both the LT (26 vs. 15%; P = 0.05) and time to fatigue (164 vs. 123%; P = 0.05) after Alk-T, compared with Pla-T. There were no changes to pre- or postexercise ATP, phosphocreatine, creatine, and intracellular lactate concentrations, or pH i after training. Our findings suggest that training intensity, rather than the accumulation of H+ during training, may be more important to improvements in βm. The group ingesting NaHCO 3 before each training session had larger improvements in the LT and endurance performance, possibly because of a reduced metabolic acidosis during training and a greater improvement in muscle oxidative capacity.
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In one study, long-term NaHCO3 ingestion with interval training improved lactate threshold and short-term endurance performance compared with placebo.
“One study used long-term NaHCO3 ingestion”
From Periodized Nutrition for Athletes (2017) · cites this paper as [84]
Cites
Limiting factors for maximum oxygen uptake and determinants of endurance performance
BASSETT, D. R. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200001000-00012 · Cited by 2,410 · see citing works
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
Holloszy, J. O., & Coyle, E. F. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.831 · Cited by 1,985 · see citing works
Harris, R. C., Hultman, E., & Nordesjö, L. ‐. (1974) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517409082477 · Cited by 857 · see citing works
Burgomaster, K. A., Hughes, S. C., Heigenhauser, G. J. F., Bradwel, S. N., & Gibala, M. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01095.2004 · Cited by 856 · see citing works
Muscle respiratory capacity and fiber type as determinants of the lactate threshold
Ivy, J. L., Withers, R. T., Van Handel, P. J., Elger, D. H., & Costill, D. L. (1980) · Journal of Applied Physiology · doi:10.1152/jappl.1980.48.3.523 · Cited by 363 · see citing works
Intracellular Acidosis Enhances the Excitability of Working Muscle
Pedersen, T. H., Nielsen, O. B., Lamb, G. D., & Stephenson, D. G. (2004) · Science · doi:10.1126/science.1101141 · Cited by 306 · see citing works
Muscle glycogenolysis and H+ concentration during maximal intermittent cycling.
Spriet, L. L., Lindinger, M. I., McKelvie, R. S., Heigenhauser, G. J., & Jones, N. L. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.1.8 · Cited by 294 · see citing works
Weston, A. R., Myburgh, K. H., Lindsay, F. H., Dennis, S. C., Noakes, T. D., & Hawley, J. A. (1996) · European Journal of Applied Physiology · doi:10.1007/s004210050119 · Cited by 284 · see citing works
The relationship between plasma lactate parameters, Wpeak and 1-h cycling performance in women
Bishop, D. J., Jenkins, D. G., & MACKINNON, L. T. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199808000-00014 · Cited by 262 · see citing works
Self-citationEffect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle
Pilegaard, H., Domino, K., Noland, T. D., Juel, C., Hellsten, Y., Halestrap, A. P., & Bangsbo, J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.2.e255 · Cited by 219 · see citing works
The effects of training intensity on muscle buffer capacity in females
Edge, J., Bishop, D., & Goodman, C. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0068-6 · Cited by 210 · see citing works
Self-citationBuffering capacity of deproteinized human vastus lateralis muscle.
Parkhouse, W., Mckenzie, D., Hochachka, P., & Ovalle, W. K. (1985) · Journal of applied physiology · doi:10.1152/jappl.1985.58.1.14 · Cited by 200 · see citing works
Harmer, A. R., McKenna, M. J., Sutton, J. R., Snow, R. J., Ruell, P. A., Booth, J., Thompson, M. W., Mackay, N., Stathis, C. G., Crameri, R. M., et al. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.1793 · Cited by 195 · see citing works
Effect of training on muscle metabolism during treadmill sprinting
Nevill, M. E., Boobis, L., Brooks, S., & Williams, C. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.6.2376 · Cited by 190 · see citing works
Acid-Base Balance during Repeated Bouts of Exercise: Influence of HCO3
COSTILL, D. L., VERSTAPPEN, F. T. J., Kuipers, H., Janssen, E., & Fink, W. (1984) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025910 · Cited by 186 · see citing works
Glucose intolerance following chronic metabolic acidosis in man.
DeFronzo, R. A., & Beckles, A. D. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.4.e328 · Cited by 170 · see citing works
Acidosis inhibits oxidative phosphorylation in contracting human skeletal musclein vivo
Jubrias, S. A., Crowther, G. J., Shankland, E. G., Gronka, R. K., & Conley, K. E. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045872 · Cited by 160 · see citing works
Effects of induced metabolic alkalosis on prolonged intermittent-sprint performance
BISHOP, D., & CLAUDIUS, B. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000161803.44656.3c · Cited by 155 · see citing works
Self-citationStreet, D., Nielsen, J., Bangsbo, J., & Juel, C. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086801 · Cited by 144 · see citing works
Effect of metabolic acidosis on insulin action and secretion in uremia
MAK, R. H. K. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00023.x · Cited by 133 · see citing works
Muscle pH regulation: role of training
JUEL, C. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0305f.x · Cited by 130 · see citing works
Metabolic end products inhibit sarcoplasmic reticulum Ca2+ release and [3H]ryanodine binding
Favero, T. G., Zable, A. C., Bowman, M. B., Thompson, A., & Abramson, J. J. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.5.1665 · Cited by 125 · see citing works
Metabolic demands of intense aerobic interval training in competitive cyclists
Stepto, N. K., Martin, D. T., Fallon, K. E., & Hawley, J. A. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200102000-00021 · Cited by 122 · see citing works
e, J. E., Bishop, D. J., Hill-Haas, S. V., DAWSON, B. T., & Goodman, C. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0056-x · Cited by 104 · see citing works
Self-citationEffects of chronic bicarbonate ingestion on the performance of high-intensity work
McNaughton, L., Backx, K., Palmer, G., & Strange, N. (1999) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/s004210050600 · Cited by 103 · see citing works
Effect of training status and relative exercise intensity on physiological responses in men
Baldwin, J. C., Snow, R. J., & Febbraio, M. A. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009000-00020 · Cited by 99 · see citing works
Walsh, B. J., Tonkonogi, M., & Sahlin, K. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100538 · Cited by 94 · see citing works
Effect of acidosis on control of respiration in skeletal muscle
Harkema, S. J., & Meyer, R. A. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.272.2.c491 · Cited by 91 · see citing works
Metabolic effects of induced alkalosis during progressive forearm exercise to fatigue
Raymer, G. H., Marsh, G. D., Kowalchuk, J. M., & Thompson, R. T. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01261.2003 · Cited by 86 · see citing works
Hultman, E., Canale, S. D., & Sjöholm, H. (1985) · Clinical Science · doi:10.1042/cs0690505 · Cited by 78 · see citing works
Determination of human skeletal muscle buffer value by homogenate technique: methods of measurement
Mannion, A. F., Jakeman, P. M., & Willan, P. L. T. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1412 · Cited by 75 · see citing works
Bicarbonate attenuates intracellular acidosis
Nielsen, H. B., Hein, L., Svendsen, L. B., Secher, N., & Quistorff, B. (2002) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2002.460516.x · Cited by 71 · see citing works
Control of muscle protein kinetics by acid-base balance
Caso, G., & Garlick, P. J. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200501000-00011 · Cited by 69 · see citing works
Yoshida, T., & Watari, H. (1993) · European Journal of Applied Physiology · doi:10.1007/bf00634298 · Cited by 66 · see citing works
Plasma glucose kinetics during exercise in subjects with high and low lactate thresholds
Coggan, A. R., Kohrt, W. M., Spina, R. J., Kirwan, J. P., Bier, D. M., & Holloszy, J. O. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.1873 · Cited by 66 · see citing works
The effect of one-legged sprint training on intramuscular pH and nonbicarbonate buffering capacity
Bell, G. J., & Wenger, H. A. (1988) · European Journal of Applied Physiology · doi:10.1007/bf00636620 · Cited by 44 · see citing works
Rasmussen, U. F., Krustrup, P., Bangsbo, J., & Rasmussen, H. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100689 · Cited by 41 · see citing works
Acute metabolic acidosis inhibits muscle protein synthesis in rats
Caso, G., Garlick, B. A., Casella, G. A., Sasvary, D. H., & Garlick, P. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2003 · Cited by 40 · see citing works
Demarle, A., Heugas, A. M., SLAWINSKI, J. S., Tricot, V., Koralsztein, J. P., & Billat, V. L. (2003) · Archives of Physiology and Biochemistry · doi:10.1076/apab.111.2.167.14003 · Cited by 35 · see citing works
Effects of high-intensity interval training on the response during severe exercise
Duffield, R., Edge, J., & Bishop, D. J. (2006) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2006.03.014 · Cited by 35 · see citing works
Self-citationForbes, S. C., Raymer, G. H., Kowalchuk, J. M., & Marsh, G. D. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01200.2004 · Cited by 28 · see citing works
Haderslev, K. V., Haderslev, P. A. H., & Staun, M. (2005) · Dynamic Medicine · doi:10.1186/1476-5918-4-1 · Cited by 27 · see citing works
Bailey, J. L., & Mitch, W. E. (2000) · Seminars in Dialysis · doi:10.1046/j.1525-139x.2000.00063.x · Cited by 24 · see citing works
Gilmore, J., Squires, J. E., McBride, B. W., Mutsvangwa, T., & Lindinger, M. I. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.558 · Cited by 21 · see citing works
Changes in intracellular pH during repeated exercise
Yoshida, T., & Watari, H. (1993) · European Journal of Applied Physiology · doi:10.1007/bf00864228 · Cited by 20 · see citing works
Homma, T., Hamaoka, T., Sako, T., Murakami, M., Esaki, K., Kime, R., & Katsumura, T. (2005) · Dynamic Medicine · doi:10.1186/1476-5918-4-2 · Cited by 16 · see citing works
Caso, G., Garlick, B. A., Casella, G. A., Sasvary, D. H., & Garlick, P. J. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.026 · Cited by 7 · see citing works
Rico, H. L., Paèz, E., Aznar, L., Hern�ndez, E. R., Seco, C., Villa, L. F., & Gervás, J. J. (2001) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740170047 · Cited by 5 · see citing works
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Self-citationSmith‐Ryan, A. E., Fukuda, D. H., Kendall, K. L., & Stout, J. R. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-10 · Cited by 77 · see citing works
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Self-citationAbramowitz, M. K., Hostetter, T. H., & Melamed, M. L. (2012) · Kidney International · doi:10.1038/ki.2011.479 · Cited by 71 · see citing works
Vincent, G. E., Lamon, S., Gant, N., Vincent, P. J., MacDonald, J. R., Markworth, J. F., Edge, J., & Hickey, A. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00051 · Cited by 70 · see citing works
Self-citationBishop, D. J., Edge, J., Thomas, C., & Mercier, J. G. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00590.2006 · Cited by 69 · see citing works
Self-citationBicarbonate Loading to Enhance Training and Competitive Performance
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Grgić, J., Rodriguez, R. F., Garofolini, A., Saunders, B., Bishop, D. J., Schoenfeld, B. J., & Pedišić, Ž. (2020) · Sports Medicine · doi:10.1007/s40279-020-01275-y · Cited by 67 · see citing works
Self-citationDurkalec-Michalski, K., Zawieja, E. E., Podgórski, T., Łoniewski, I., Zawieja, B., Warzybok, M., & Jeszka, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197480 · Cited by 55 · see citing works
Walter, A. A., Smith‐Ryan, A. E., Kendall, K. L., Stout, J. R., & Cramer, J. T. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181d82f8b · Cited by 63 · see citing works
Effects of Dietary Supplements on Adaptations to Endurance Training
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Self-citationForbes, S. C., Candow, D. G., Smith‐Ryan, A. E., Hirsch, K. R., Roberts, M. D., VanDusseldorp, T. A., Stratton, M. T., Kaviani, M., & Little, J. P. (2020) · Nutrients · doi:10.3390/nu12020390 · Cited by 60 · see citing works
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Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats
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Self-citationEdge, J., Eynon, N., McKenna, M. J., Goodman, C. A., Harris, R. C., & Bishop, D. J. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.067603 · Cited by 52 · see citing works
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Performance and physiological responses to repeated-sprint and jump sequences
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Sodium bicarbonate supplementation improves hypertrophy-type resistance exercise performance
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Painelli, V. D. S., Saunders, B., Sale, C., Harris, R. C., Solis, M. Y., Roschel, H., Gualano, B., Artioli, G. G., & Lancha, A. H. (2014) · Amino Acids · doi:10.1007/s00726-014-1678-2 · Cited by 47 · see citing works
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Burke, L. M. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000345814 · Cited by 41 · see citing works
Timing of ergogenic aids and micronutrients on muscle and exercise performance
Stecker, R. A., Harty, P. S., Jagim, A. R., Candow, D. G., & Kerksick, C. M. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0304-9 · Cited by 40 · see citing works
De Smet, S., Van Thienen, R., Deldicque, L., James, R., Sale, C., Bishop, D. J., & Hespel, P. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00233 · Cited by 39 · see citing works
Self-citationBishop, D. J., Edge, J., Méndez-Villanueva, A., Thomas, C., & SCHNEIKER, K. T. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0673-z · Cited by 39 · see citing works
Self-citationNutrition and Training Adaptations in Aquatic Sports
Mujika, I., Stellingwerff, T., & Tipton, K. D. (2014) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2014-0033 · Cited by 39 · see citing works
Relationship Between Repeated Sprint Performance and both Aerobic and Anaerobic Fitness
Dardouri, W., Selmi, M. A., Sassi, R. H., Gharbi, Z., Rebhi, A., Yahmed, M. H., & Moalla, W. (2014) · Journal of Human Kinetics · doi:10.2478/hukin-2014-0016 · Cited by 38 · see citing works
Raleigh, J. P., Giles, M. D., Scribbans, T. D., Edgett, B. A., Sawula, L. J., Bonafiglia, J. T., Graham, R. B., & Gurd, B. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0614 · Cited by 35 · see citing works
Ricci, A., Evans, C., Stull, C., Peacock, C. A., French, D. N., Stout, J. R., Fukuda, D. H., Bounty, P. L., Kalman, D., Galpin, A. J., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2467909 · Cited by 34 · see citing works
Saoi, M., Percival, M. E., Nemr, C. R., Li, A., Gibala, M. J., & Britz‐McKibbin, P. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00149 · Cited by 34 · see citing works
A randomized controlled trial of a new treatment for labor dystocia
Wiberg‐Itzel, E., Wray, S., & Åkerud, H. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1339268 · Cited by 33 · see citing works
Wang, J., Qiu, J., Yi, L., Hou, Z., Benardot, D., & Cao, W. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0285-8 · Cited by 32 · see citing works
Quaresma, M. V. L. D. S., Marques, C. G., & Nakamoto, F. P. (2020) · Nutrition · doi:10.1016/j.nut.2020.110994 · Cited by 32 · see citing works
Freis, T., Hecksteden, A., Such, U., & Meyer, T. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182158 · Cited by 31 · see citing works
Calvo, J. L., Xu, H., Mon-López, D., Pareja-Galeano, H., & Jiménez, S. L. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00410-y · Cited by 30 · see citing works
McGinley, C., & Bishop, D. J. (2016) · Experimental Physiology · doi:10.1113/ep085921 · Cited by 30 · see citing works
Self-citationGraham, R. B., Wachowiak, M. P., & Gurd, B. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135069 · Cited by 28 · see citing works
Influence of exercise on nutritional requirements
Pendergast, D. R., Meksawan, K., Limprasertkul, A., & Fisher, N. M. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1710-5 · Cited by 27 · see citing works
Performance Enhancing Diets and the PRISE Protocol to Optimize Athletic Performance
Arciero, P. J., Miller, V. J., & Ward, E. G. (2015) · Journal of Nutrition and Metabolism · doi:10.1155/2015/715859 · Cited by 27 · see citing works
Saunders, B., de Oliveira, L. F., Dolan, E., Durkalec‐Michalski, K., McNaughton, L. R., Artioli, G. G., & Swinton, P. A. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2021.1880649 · Cited by 26 · see citing works
Effects of extracellular HCO3−on fatigue, pHi, and K+efflux in rat skeletal muscles
Broch‐Lips, M., Overgaard, K., Prætorius, H. A., & Nielsen, O. B. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00049.2007 · Cited by 26 · see citing works
Płoszczyca, K., Jazic, D., Piotrowicz, Z., Chalimoniuk, M., Langfort, J., & Czuba, M. (2020) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-020-00219-3 · Cited by 25 · see citing works
Sodium bicarbonate treatment prevents gastric emptying delay caused by acute exercise in awake rats
da Silva, M. T. B., Palheta, R. C., de Sousa, D. F., Fonseca-Magalhães, P. A., Okoba, W., Campos, C. P. S., de Oliveira, R. B., Magalhães, P. J. C., & dos Santos, A. A. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01242.2013 · Cited by 25 · see citing works
Ghiarone, T., Andrade‐Souza, V. A., LEARSI, S. K., Tomazini, F., Ataide‐Silva, T., Sansonio, A., Fernandes, M. P., Saraiva, K., de Figueiredo, R. C. B. Q., Tourneur, Y., et al. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00060.2019 · Cited by 25 · see citing works
Self-citationDietary Supplements for Aquatic Sports
Derave, W., & Tipton, K. D. (2014) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2014-0017 · Cited by 22 · see citing works
Legal pre-event nutritional supplements to assist energy metabolism.
Spriet, L., Perry, C. G., & Talanian, J. (2008) · Essays in Biochemistry · doi:10.1042/bse0440027 · Cited by 24 · see citing works
Coso, J. D., Hamouti, N., Aguado-Jiménez, R., & Mora‐Rodríguez, R. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1101-y · Cited by 21 · see citing works
Sodium Bicarbonate—A Potent Ergogenic Aid?
Shelton, J., & Kumar, G. V. P. (2010) · Food and Nutrition Sciences · doi:10.4236/fns.2010.11001 · Cited by 20 · see citing works
Ammonium Chloride Ingestion Attenuates Exercise-Induced mRNA Levels in Human Muscle
Edge, J., Mündel, T., Pilegaard, H., Hawke, E. J., Leikis, M. J., Lopez-Villalobos, N., Oliveira, R. S. F., & Bishop, D. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141317 · Cited by 20 · see citing works
Self-citationMcGinley, C., & Bishop, D. J. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00459.2016 · Cited by 16 · see citing works
Self-citationCarr, A. J., McKay, A. K. A., Burke, L. M., Smith, E. S., Urwin, C. S., Convit, L., Jardine, W. T., Kelly, M. K., & Saunders, B. (2023) · Sports Medicine · doi:10.1007/s40279-023-01872-7 · Cited by 14 · see citing works
Brancaccio, P., Limongelli, F. M., Paolillo, I., D’Aponte, A., Donnarumma, V., & Rastrelli, L. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-35 · Cited by 14 · see citing works
Acid-Base Balance and Physical Function
Abramowitz, M. K. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10371014 · Cited by 13 · see citing works
Higgins, M. F., Tallis, J. A., Price, M., & James, R. S. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2557-8 · Cited by 13 · see citing works
Effect of Stacked Sodium Bicarbonate Loading on Repeated All-out Exercise
Dalle, S., De Smet, S., Geuns, W., Rompaye, B. V., Hespel, P., & Koppo, K. (2019) · International Journal of Sports Medicine · doi:10.1055/a-0978-5139 · Cited by 11 · see citing works
Whitfield, J., Egan, B., Coso, J. D., Derave, W., Saunders, B., & Burke, L. M. (2025) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2025-0111 · Cited by 11 · see citing works
Thomas, C., Delfour‐Peyrethon, R., Lambert, K., Granata, C., Hobbs, T., Hanon, C., & Bishop, D. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1073407 · Cited by 11 · see citing works
Self-citationNutritional Strategies to Support Adaptation to High-Intensity Interval Training in Team Sports
Gibala, M. J. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000345817 · Cited by 10 · see citing works
Limmer, M., de Marées, M., & Platen, P. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00351-y · Cited by 9 · see citing works
Supplements and Ergogenic Aids
Braun, H., Currell, K., & Stear, S. J. (2011) · Wiley eBooks · doi:10.1002/9781444344905.ch9 · Cited by 9 · see citing works
Correia‐Oliveira, C. R., & Lopes‐Silva, J. P. (2022) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2022.2031847 · Cited by 6 · see citing works
Karayiğit, R., Ramírez‐Campillo, R., Yaşli, B. Ç., Gabrys, T. T., Benešová, D., & Esen, Ö. (2022) · Biology · doi:10.3390/biology11101463 · Cited by 6 · see citing works
Lino, R. D. S., Lagares, L. S., de Oliveira, C. V. C., Queiroz, C. O., Pinto, L. L. T., de Almeida, L. A. B., Bomfim, E. S., & dos Santos, C. P. C. (2021) · Physical Activity and Nutrition · doi:10.20463/pan.2021.0002 · Cited by 6 · see citing works
Elsebai, M. F., & Habib, E. E. (2023) · Archiv der Pharmazie · doi:10.1002/ardp.202200558 · Cited by 5 · see citing works
Álvarez, M. R., Alarcón, J. M., Roman, C. A. J., Lazaro, D. M., Bobrowski‐Khoury, N., Baena-Caldas, G. P., & Esber, G. R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106525 · Cited by 5 · see citing works
Zhou, N., Fan, Y., Kong, X., Wang, X., Wang, J., & Wu, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931671 · Cited by 3 · see citing works
Training-Induced Metabolic Adaptations in Skeletal Muscle
García-Domínguez, E., Gómez‐Cabrera, M. C., & Gonzalez, G. O. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_21 · Cited by 3 · see citing works
Brancaccio, P. (2012) · The Open Sports Medicine Journal · doi:10.2174/1874387001206010001 · Cited by 3 · see citing works
Effects of aerobic and anaerobic training on freedivers' performance
Drviš, I., Vrdoljak, D., Ružić, L., Dujić, G., Dujić, Ž., & Foretić, N. (2024) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.24.16436-5 · Cited by 3 · see citing works
Buffering your way to sub-4! An important consideration for middle-distance performance
Stellingwerff, T., Saunders, B., & Siegler, J. C. (2025) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00441.2025 · Cited by 2 · see citing works
Hagele, A. M., Boring, J. L., Moon, J. M., Sunderland, K., Mumford, P. W., & Kerksick, C. M. (2023) · Nutrients · doi:10.3390/nu15245052 · Cited by 2 · see citing works
- Authors
- Edge, J., Bishop, D., & Goodman, C.
- Affiliations
- The University of Western Australia (AU)
- ORCID
- Bishop, David
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2006-09
- Volume
- 101
- Issue
- 3
- Pages
- 918-925
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2007237261
- Cited by
- 137
- References
- 48
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 14 · 2012: 10
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sodium bicarbonate ingestion, interval training, metabolic acidosis, lactate threshold, peak oxygen uptake, time to exhaustion, endurance performance, muscle metabolites, intracellular pH, exercise intensity, women
- MeSH terms
- Adaptation, Physiological, Administration, Oral, Adult, Humans, Hydrogen-Ion Concentration, Male, Oxygen, Oxygen Consumption, Physical Endurance, Physical Fitness, Task Performance and Analysis, Time Factors, Anaerobic Threshold, Exercise, Sodium Bicarbonate, Muscle, Skeletal
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