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Review article: short chain fatty acids in health and disease

Cook, Sellin·1998·Alimentary Pharmacology & Therapeutics
DOI 10.1046/j.1365-2036.1998.00337.x
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Abstract

Short chain fatty acids (SCFAs) have been the subject of much research over the past few decades. They play a vital role in maintenance of colonic integrity and metabolism. They are produced when dietary fibre is fermented by colonic bacteria. SCFAs are avidly absorbed in the colon, at the same time as sodium and water absorption and bicarbonate secretion. Once absorbed, SCFAs are used preferentially as fuel for colonic epithelial cells and have trophic effects on the epithelium. Clinically, SCFAs have been studied as possible therapeutic agents in diversion colitis, ulcerative colitis, radiation proctitis, pouchitis and antibiotic‐associated diarrhoea. Although some promising effects have been observed in uncontrolled studies, a specific therapeutic role for SCFAs remains to be defined. SCFAs may be the effector of the beneficial role of fibre in prevention of colon cancer.

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Research works printed but not linked: 49

  1. 10.1007/BF00180540 · DOI
  2. 10.3109/00365529609094568 · DOI · Paper page
  3. 10.1016/0016-5085(90)90954-Y · DOI
  4. 10.1016/S0261-5614(09)90016-4 · DOI
  5. 10.1152/ajpcell.1996.271.6.C1853 · DOI
  6. 10.1073/pnas.92.8.3303 · DOI
  7. Jenkins DJ., 1989, Editorial, Am J Gastroenterol, 84, 1362
  8. 10.1177/014860719201600101 · DOI
  9. 10.1136/gut.31.12.1391 · DOI · Paper page
  10. 10.1016/0016-5085(94)90595-9 · DOI · Paper page
  11. Harig JM, 1991, Transport of propionate by human ileal brush border membrane vesicles, Am J Physiol, 260, 776
  12. 10.1007/BF02055684 · doi:10.1007/bf02055684
  13. 10.1056/NEJM198901053200105 · DOI · Paper page
  14. 10.1007/BF02049697 · DOI
  15. Patz J, 1996, Treatment of refractory distal ulcerative colitis with short chain fatty acid enemas, Am J Gastroenterol, 91, 731
  16. 10.1046/j.1365-2036.1996.d01-509.x · DOI · Paper page
  17. 10.1016/0016-5085(93)91016-B · DOI · Paper page
  18. 10.1136/gut.39.1.1 · DOI · Paper page
  19. 10.1007/BF01536987 · DOI · Paper page
  20. Brunkhorst BA, 1992, Proprionate induces polymorphonuclear activation and inhibits formyl methioyl‐lencyl‐phenylalanine stimulated activation, Infection Immunity, 60, 2957, 10.1128/iai.60.7.2957-2968.1992 · DOI
  21. 10.1007/BF01300754 · DOI · Paper page
  22. 10.1016/0016-5085(92)91094-K · DOI · Paper page
  23. 10.1007/BF02065414 · DOI
  24. 10.1136/gut.40.4.485 · DOI · Paper page
  25. EarnestDL&TrierJS.Radiation enteritis and colitis. In: Sleisenger MH Fordtran JS eds. Gastrointestinal Disease 5th edn. Philadelphia: WB Saunders Company 1993; 1182.
  26. Al‐Sabbagh R, 1996, Evaluation of short‐chain fatty acid enemas: Treatment of radiation proctitis, Am J Gastroenterol, 91, 1814
  27. 10.1007/BF01308083 · DOI
  28. 10.1016/0016-5085(92)91497-R · DOI
  29. DeSilvaHJ IrelandA KettlewellM et al. Short chain fatty acid irrigation in severe pouchitis. N Engl J Med 1989; 321: 1416–17. · DOI
  30. 10.1016/S0025-6196(12)62270-8 · DOI
  31. 10.1016/0016-5085(91)90384-W · DOI · Paper page
  32. 10.1016/0016-5085(89)91614-4 · DOI · Paper page
  33. 10.1002/ijc.2910600322 · DOI · Paper page
  34. 10.1136/gut.34.3.386 · DOI · Paper page
  35. 10.1136/gut.29.11.1539 · DOI
  36. 10.1016/B978-0-12-364932-4.50010-1 · DOI · Paper page
  37. Hague A, Sodium butyrate induces apoptosis in human colonic tumour cell lives in a P53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large bowel cancer, Int J Cancer, 55, 498, 10.1002/ijc.2910550329 · DOI · Paper page
  38. 10.1007/s004410050677 · DOI
  39. Barnard JA, 1993, Butyrate rapidly induces growth inhibition and differentiation in HT‐29 cells, Cell Growth Differentiation, 4, 495
  40. 10.1016/0959-8049(95)00165-F · DOI · Paper page
  41. 10.1056/NEJM198502073120602 · DOI · Paper page
  42. 10.1056/NEJM199301143280202 · DOI · Paper page
  43. Collins AF, 1997, Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial, Blood, 85, 43, 10.1182/blood.V85.1.43.bloodjournal85143 · DOI · Paper page
  44. 10.1002/1097-0142(19800315)45:5 <1185::AID-CNCR2820451324>3.0.CO;2-W · doi:10.1002/1097-0142(19800315)45:5
  45. 10.1053/gast.1997.v112.pm9041249 · DOI
  46. Whitlock JP, 1983, Acetylation and calcium dependent phosphorylation of histone H3 in nuclei from butyrate treated HeLa cells, J Biol Chem, 258, 1299, 10.1016/S0021-9258(18)33193-4 · DOI
  47. 10.1136/gut.35.7.969 · doi:10.1136/gut.35.7.969
  48. 10.1016/0016-5085(94)90549-5 · DOI
  49. 10.1016/0016-5085(94)90166-X · DOI

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Metadata

Authors
Cook, & Sellin
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
1998-06
Volume
12
Issue
6
Pages
499-507
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1046/j.1365-2036.1998.00337.x
OpenAlex
W2064654077
Cited by
619
References
0
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1303 d)

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Cook, & Sellin. (1998). Review article: short chain fatty acids in health and disease. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1046/j.1365-2036.1998.00337.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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