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Skin, immunity and the nervous system

MISERY, L.·1997·British Journal of Dermatology
DOI 10.1046/j.1365-2133.1997.19762090.x
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Abstract

Connections between nerve fibres and cutaneous cells have been studied using confocal and electron microscopy. In the skin, nerve fibres may secrete neuromediators, i.e. substance P, vasoactive intestinal peptide, somatostatin, calcitonin-gene-related peptide, gastrin-releasing peptide, neuropeptide Y, peptide histidine-isoleucine, neurotensin, neurokinins A and B, bradykinin, acetylcholine, catecholamines, endorphins and enkephalins. Neurohormones such as prolactin, melanocyte-stimulating hormone and adrenocorticotrophic hormone are also expressed in the skin. Neuromediators and neurohormones may be secreted by cutaneous cells, which also express receptors. Functions of epidermal and dermal cells are modulated by these substances. Immune cells transiently present in the skin (e.g. macrophages and lymphocytes) are modulated by neuromediators through receptors. During the course of skin disorders, especially inflammatory reactions, the neuroimmunocutaneous system is destabilized. This is particularly true in psoriasis. This destabilization may be secondary, although evidence shows it can also be responsible for the induction and maintenance of the inflammatory process. The skin, the nervous system and immunity are not independent systems but are closely associated and use the same language of cytokines and neurotransmitters. A new concept is suggested: the neuroimmunocutaneous system.

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Metadata

Authors
MISERY, L.
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
1997-12
Volume
137
Issue
6
Pages
843-850
ISSN
0007-0963 (ISSN-L)
DOI
10.1046/j.1365-2133.1997.19762090.x
OpenAlex
W2064372232
Cited by
178
References
2
FWCI
2.03
Type
journal article
Language
en
Open access
closed
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