Effect of ageing on tactile transduction processes
Abstract
With advancing age, a decline in the main sensory modalities including touch sensation and perception is well reported to occur. This review mainly outlines the peripheral components of touch perception highlighting ageing influences on morphological and functional features of cutaneous mechanical transducers and mechanosensitive ion channels, sensory innervation, neurotransmitters and even vascular system required to ensure efferent function of the afferent nerve fibres in the skin. This, in conjunction with effect of ageing on the skin per se and central nervous system, could explain the tactile deficit seen among the ageing population. We also discuss appropriate tools and experimental models available to study the age-related tactile decline.
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The decrease in the number of fibers due to aging is more pronounced in some body regions than others, and the skin of the face, arms, legs, hands, and feet is most affected, while the number of fibers innervating the abdomen remains almost unchanged.
“There is evidence that the decrease in the number of fibers due to aging is more pronounced in some body regions than others, and that the skin of the face, arms, legs, hands, and feet is most affected, while the number of fibers innervating the abdomen remains almost unchanged (Decorps et al. 2014).”
From Tactile innervation densities across the whole body (2020) · cites this paper as Decorps et al. 2014
Cites
Vitamin D deficiency: a worldwide problem with health consequences
Holick, M. F., & Chen, T. C. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1080s · Cited by 2,689 · see citing works
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J., Wang, Z., Datta, S. C., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00902.x · Cited by 643 · see citing works
The neurophysiology of unmyelinated tactile afferents
Olausson, H., Wessberg, J., Morrison, I., McGlone, F., & Vallbo, Å. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.011 · Cited by 587 · see citing works
Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin
Vallbo, Å. B., Olausson, H., & Wessberg, J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.2753 · Cited by 571 · see citing works
Osorio, F. G., Bárcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., & López-Otín, C. (2012) · Genes & Development · doi:10.1101/gad.197954.112 · Cited by 276 · see citing works
Tactile Sensitivity as a Function of Age
Thornbury, J. M., & Mistretta, C. M. (1981) · Journal of Gerontology · doi:10.1093/geronj/36.1.34 · Cited by 246 · see citing works
Influence of aging on thermal and vibratory thresholds of quantitative sensory testing
Lin, Y., Hsieh, S., Chao, C., Chang, Y., & Hsieh, S. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10305.x · Cited by 176 · see citing works
VDR gene variants associate with cognitive function and depressive symptoms in old age
Kuningas, M., Mooijaart, S. P., Jolles, J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.001 · Cited by 149 · see citing works
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Tactile innervation densities across the whole body
Corniani, G., & Saal, H. P. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00313.2020 · Cited by 396 · see citing works
- Authors
- Decorps, J., Saumet, J. L., Sommer, P., Sigaudo-Roussel, D., & Fromy, B.
- Affiliations
- Lyon 1 Université (FR)
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 13
- Pages
- 90-99
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2077895932
- Cited by
- 83
- References
- 9
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 6 · 2021: 11 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 5
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- aging, tactile perception, mechanosensitive ion channels, cutaneous mechanoreceptors, sensory innervation, neurotransmitters, afferent nerve fibers, skin aging
- MeSH terms
- Age Factors, Aging, Animals, Humans, Microcirculation, Physical Stimulation, Pressure, Sensory Receptor Cells, Regional Blood Flow, Skin, Touch, Models, Animal, Mechanotransduction, Cellular, Mice, Rats, Touch Perception
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