The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells
Open accessAbstract
Maternal IgG is transferred to the suckling mouse and rat through a major histocompatibility complex (MHC) class I‐related Fc receptor (FcRn) on the brush border of the proximal small intestine. We have previously described a site on the epithelial surface of the human fetal intestine with IgG binding characteristics similar to FcRn. We report here the identification by reverse transcriptase polymerase chain reaction amplification and sequencing of the human orthologue of rat and mouse FcRn in tissue obtained from human fetal and adult intestine. FcRn protein was detected in adult human intestine by western blot. Immunohistochemical studies of sections of human intestine show that the FcRn is localized mostly to the epithelial cells, where it is in the apical region. These data suggest that the binding of IgG previously seen in the fetal intestine is due to the presence of FcRn. Potential roles for this MHC class I‐like Fc receptor in the human intestine include the transfer of passive immunity, induction of oral tolerance, and immunosurveillance.
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Cites
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Self-citationSpontaneous development of inflammatory bowel disease in T cell receptor mutant mice
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Self-citationIncreased clearance of IgG in mice that lack β2‐microglobulin: possible protective role of FcRn
ISRAEL, E. J., WILSKER, D. F., HAYES, K. C., SCHOENFELD, D., & SIMISTER, N. E. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-775.x · Cited by 333
Self-citationAn IgG‐transporting Fc receptor expressed in the syncytiotrophoblast of human placenta
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Self-citationPrevention of Necrotizing Enterocolitis in Low-Birth-Weight Infants by IgA–IgG Feeding
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Cited by
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Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
FcRn: the neonatal Fc receptor comes of age
Roopenian, D. C., & Akilesh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2155 · Cited by 2,346
Perspectives on Immunoglobulins in Colostrum and Milk
Hurley, W. L., & Theil, P. K. (2011) · Nutrients · doi:10.3390/nu3040442 · Cited by 687
Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line
Dickinson, B. L., Badizadegan, K., Wu, Z., Ahouse, J. C., Zhu, X., Simister, N. E., Blumberg, R. S., & Lencer, W. I. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6968 · Cited by 434
Self-citationThe Neonatal Fc Receptor (FcRn): A Misnomer?
Pyzik, M., Sand, K. M. K., Hubbard, J. J., Andersen, J. T., Sandlie, I., & Blumberg, R. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01540 · Cited by 429
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Metadata
- Authors
- ISRAEL, E. J., TAYLOR, S., WU, Z., MIZOGUCHI, E., BLUMBERG, R. S., BHAN, A., & SIMISTER, N. E.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 1997-09
- Volume
- 92
- Issue
- 1
- Pages
- 69-74
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W2075689961
- Cited by
- 329
- References
- 21
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- ISRAEL, E. J., TAYLOR, S., WU, Z., MIZOGUCHI, E., BLUMBERG, R. S., BHAN, A., & SIMISTER, N. E. (1997). Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology. https://doi.org/10.1046/j.1365-2567.1997.00326.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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