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Cited by 78Immunotherapy and Immune ResponsesContact Dermatitis and AllergiesT-cell and B-cell Immunology

Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin‐1β

Cumberbatch, Marie, Dearman, Rebecca J., Kimber, Ian·2002·Immunology
DOI 10.1046/j.1365-2567.2002.01381.x
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Abstract

Summary: Previous studies in mice have reported a decrease in epidermal Langerhans cell (LC) density in aged skin, however, the impact of this reduction on LC function and cutaneous immune responses is unclear. In the present series of experiments, the frequency of major histocompatibility complex class II+ LC in the epidermis of older (6‐month‐old) mice was found to be reduced significantly compared with that observed for young (6–8‐week‐old) mice. LC mobilization and the subsequent accumulation of dendritic cells (DC) in regional lymph nodes in response to topical challenge with a chemical allergen were found to be less vigorous in older mice. Flow cytometric analyses of DC derived from the draining lymph nodes of fluorescein isothiocyanate (FITC)‐sensitized mice revealed that the frequency of FITC+‐DC arriving in draining lymph nodes was also reduced in older mice but that the fluorescence intensity was comparable. Control and allergen‐treated‐older mice also displayed decreased total lymph node cellularity. Contact hypersensitivity responses were found not to be compromised in older mice. However, the cytokine regulation of LC migration in the two age groups of mice did differ. LC migration provoked by intradermal injection of tumour necrosis factor‐α (TNF‐α) was reduced in older animals, whereas, the percentage of LC that migrated in response to exogenous interleukin‐1β (IL‐1β) was comparable for both young and aged mice. Since both allergen‐ and TNF‐α‐induced LC responses are known to require receipt by LC of a signal from IL‐1β for effective migration, the suggestion is that impaired LC migration in older mice may be due to a reduced availability of epidermal IL‐1β.

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  • Many immune cell subsets become hyporesponsive to acute challenges with age.

    “Thus, many immune cell subsets become hyporesponsive to acute challenges as we age17,19-25.”

    From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [20]

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Authors
Cumberbatch, M., Dearman, R. J., & Kimber, I.
Affiliations
Syngenta (United Kingdom) (GB)
Corresponding author
Cumberbatch, Marie
ORCID
Kimber, Ian
Venue
Immunology
Publisher
Wiley
Published
2002-04
Volume
105
Issue
4
Pages
466-477
ISSN
  • 0019-2805 (ISSN-L)
  • 1365-2567
DOI
10.1046/j.1365-2567.2002.01381.x
OpenAlex
W2001018816
Cited by
78
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 1 · 2013: 3 · 2012: 2
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7 d)
Locations
  • Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
Langerhans cells, aging, Langerhans cell migration, dendritic cells, skin immune response, contact hypersensitivity, TNF-α, draining lymph nodes, MHC class II
MeSH terms
Aging, Allergens, Animals, Histocompatibility Antigens Class II, Cell Count, Cell Movement, Cells, Cultured, Dendritic Cells, Dermatitis, Contact, Epidermis, Flow Cytometry, Fluorescent Dyes, Interleukin-1, Langerhans Cells, Lymph Nodes, Mice, Inbred BALB C, Oxazolone, Tumor Necrosis Factor-alpha, Fluorescein-5-isothiocyanate, Mice

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