The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cross‐presentation of cell‐associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells
Open accessAbstract
Summary: In the mouse, cross‐presentation is an exclusive property of the CD8α+ subset of dendritic cells (DC) but the basis for this selectivity remains unclear. Here we report that splenic CD8α+ DC are much superior to other DC subsets in internalizing dying cells in vitro. In contrast, CD8α+, CD8α– CD4+ and CD8α– CD4– DC subsets phagocytose bacteria or latex beads to a similar extent. Although CD8α+ DC are better than CD4+ DC at presenting ovalbumin (OVA)‐loaded splenocytes to naïve OT‐I T lymphocytes, CD4+ DC are better at presenting OVA‐expressing Escherichia coli to the same T cells. In both cases, presentation is abrogated by lactacystin. These results show that both splenic CD8α+ and CD8α– DC can present exogenous antigens on major histocompatibility complex (MHC) class I via a proteasome‐dependent pathway and suggest that the specialized cross‐presenting function of CD8α+ DC is a result of their ability to endocytose dying cells rather than a unique pathway for handling endosomal contents.
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Cites
Cross-Presentation, Dendritic Cells, Tolerance and Immunity
Heath, W. R., & Carbone, F. R. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.47 · Cited by 882
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V. (1993) · Nature · doi:10.1038/361359a0 · Cited by 615
Cited by
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Pereira da Costa, M., & Reis e Sousa, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053707 · Cited by 757
Self-citationDuong, E., Fessenden, T. B., Lutz, E., Dinter, T., Yim, L., Blatt, S., Bhutkar, A., Wittrup, K. D., & Spranger, S. (2022) · Immunity · doi:10.1016/j.immuni.2021.10.020 · Cited by 372
Zacca, E. R., Crespo, M. I., Acland, R. P., Roselli, E., Núñez, N. G., Maccioni, M., Maletto, B. A., Pistoresi-Palencia, M. C., & Morón, G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140672 · Cited by 66
Metadata
- Authors
- Schulz, O., & Reis e Sousa, C.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2002-10
- Volume
- 107
- Issue
- 2
- Pages
- 183-189
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W1578114463
- Cited by
- 214
- References
- 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schulz, O., & Reis e Sousa, C. (2002). Cross‐presentation of cell‐associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells. Immunology. https://doi.org/10.1046/j.1365-2567.2002.01513.x
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