The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Interactions between components of the essential oil of Melaleuca alternifolia
Abstract
AIMS: This study compared the antimicrobial activity of Melaleuca alternifolia (tea tree) oil with that of some of its components, both individually and in two-component combinations. METHODS AND RESULTS: Minimum inhibitory concentration and time-kill assays revealed that terpinen-4-ol, the principal active component of tea tree oil, was more active on its own than when present in tea tree oil. Combinations of terpinen-4-ol and either gamma-terpinene or p-cymene produced similar activities to tea tree oil. Concentration-dependent reductions in terpinen-4-ol activity and solubility also occurred in the presence of gamma-terpinene. CONCLUSION: Non-oxygenated terpenes in tea tree oil appear to reduce terpinen-4-ol efficacy by lowering its aqueous solubility. SIGNIFICANCE AND IMPACT OF THE STUDY: These findings explain why tea tree oil can be less active in vitro than terpinen-4-ol alone and further suggest that the presence of a non-aqueous phase in tea tree oil formulations may limit the microbial availability of its active components.
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Cites
Mechanisms of membrane toxicity of hydrocarbons
Sikkema, J., de Bont, J. A., & Poolman, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.201-222.1995 · Cited by 2,685 · cited 1×
“Hydrophobic compounds can be toxic to microorganisms because they preferentially partition into and damage the structure and function of cell membranes (Sikkema et al. 1995).”
BackgroundCharacterization of the action of selected essential oil components on Gram-negative bacteria
Helander, I. M., Alakomi, H.-L., Latva-Kala, K., Mattila-Sandholm, T., Pol, I., Smid, E. J., Gorris, L. G. M., & von Wright, A. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980154m · Cited by 1,664
Cox, S. D., Mann, C. M., Markham, J. L., Bell, H. C., Gustafson, J. E., Warmington, J. R., & Wyllie, S. G. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2000.00943.x · Cited by 1,117
Self-citationAntimicrobial activity of the major components of the essential oil of Melaleuca alternifolia
Carson, C. F., & Riley, T. V. (1995) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1995.tb05025.x · Cited by 628
Griffin, S. G., Wyllie, S. G., Markham, J. L., & Leach, D. N. (1999) · Flavour and Fragrance Journal · doi:10.1002/(sici)1099-1026(199909/10)14:5<322::aid-ffj837>3.0.co;2-4 · Cited by 515
Self-citationGas chromatographic quality control for oil of Melaleuca terpinen-4-ol type (Australian tea tree)
Brophy, J. J., Davies, N. W., Southwell, I. A., Stiff, I. A., & Williams, L. R. (1989) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00089a027 · Cited by 282
Mann, C. M., Cox, S. D., & Markham, J. L. (2000) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2000.00712.x · Cited by 262
Self-citationSdol, E. (2009) · Cited by 212
THE SEARCH FOR OPTIMALLY BIOACTIVE AUSTRALIAN TEA TREE OIL
Southwell, I. A., Hayes, A. J., Markham, J. L., & Leach, D. N. (1993) · Acta Horticulturae · doi:10.17660/actahortic.1993.344.30 · Cited by 76
Self-citationBIOLOGICAL ACTIVITY OF TEA TREE OIL
Markham, J. (1999) · CRC Press eBooks · doi:10.1201/9780203303603-19 · Cited by 24
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Cited by
Invited review: essential oils as modifiers of rumen microbial fermentation
Calsamiglia, S., Busquet, M., Cardozo, P. W., Castillejos, L., & Ferret, A. (2007) · Journal of Dairy Science · doi:10.3168/jds.2006-644 · Cited by 1,014
Chaieb, K., Hajlaoui, H., Zmantar, T., Kahla‐Nakbi, A. B., Rouabhia, M., Mahdouani, K., & Bakhrouf, A. (2007) · Phytotherapy Research · doi:10.1002/ptr.2124 · Cited by 934
Cross, D. E., McDevitt, R. M., Hillman, K., & Acamovic, T. (2007) · British Poultry Science · doi:10.1080/00071660701463221 · Cited by 578
Anti-staphylococcal plant natural products
Gibbons, S. (2004) · Natural Product Reports · doi:10.1039/b212695h · Cited by 531
Phytochemicals as antibiotic alternatives to promote growth and enhance host health
Lillehoj, H., Liu, Y., Calsamiglia, S., Fernandez-Miyakawa, M. E., Chi, F., Cravens, R. L., Oh, S., & Gay, C. G. (2018) · Veterinary Research · doi:10.1186/s13567-018-0562-6 · Cited by 515
Metadata
- Authors
- Cox, S. D., Mann, C. M., & Markham, J. L.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09-12
- Volume
- 91
- Issue
- 3
- Pages
- 492-497
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W1988317345
- Cited by
- 301
- References
- 10
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
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