Phytochemicals as antibiotic alternatives to promote growth and enhance host health

Lillehoj, Hyun; Liu, Yanhong; Calsamiglia, Sergio; Fernandez-Miyakawa, Mariano E.; Chi, Fang; Cravens, Ron L.; Oh, Sungtaek; Gay, Cyril G.

doi:10.1186/s13567-018-0562-6

Cited by 515Animal Nutrition and PhysiologyVeterinary medicine and infectious diseasesEssential Oils and Antimicrobial Activity

Phytochemicals as antibiotic alternatives to promote growth and enhance host health

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Lillehoj, Hyun, Liu, Yanhong, Calsamiglia, Sergio, Fernandez-Miyakawa, Mariano E., Chi, Fang, Cravens, Ron L., Oh, Sungtaek, Gay, Cyril G.·2018·Veterinary Research

DOI 10.1186/s13567-018-0562-6PMC PMC6066919

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Abstract

International Symposium on Alternatives to Antibiotics was held at the World Organization for Animal Health in Paris, France, December 12-15, 2016 to discuss recent scientific developments on strategic antibiotic-free management plans, to evaluate regional differences in policies regarding the reduction of antibiotics in animal agriculture and to develop antibiotic alternatives to combat the global increase in antibiotic resistance. More than 270 participants from academia, government research institutions, regulatory agencies, and private animal industries from >25 different countries came together to discuss recent research and promising novel technologies that could provide alternatives to antibiotics for use in animal health and production; assess challenges associated with their commercialization; and devise actionable strategies to facilitate the development of alternatives to antibiotic growth promoters (AGPs) without hampering animal production. The 3-day meeting consisted of four scientific sessions including vaccines, microbial products, phytochemicals, immune-related products, and innovative drugs, chemicals and enzymes, followed by the last session on regulation and funding. Each session was followed by an expert panel discussion that included industry representatives and session speakers. The session on phytochemicals included talks describing recent research achievements, with examples of successful agricultural use of various phytochemicals as antibiotic alternatives and their mode of action in major agricultural animals (poultry, swine and ruminants). Scientists from industry and academia and government research institutes shared their experience in developing and applying potential antibiotic-alternative phytochemicals commercially to reduce AGPs and to develop a sustainable animal production system in the absence of antibiotics.

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Putative mechanisms of actions mainly include disturbance of the cytoplasmic membrane, disruption of the proton motive force, electron flow, active transport mechanisms, and coagulation of cell composition.
“Putative mechanisms of actions mainly include disturbance of the cytoplasmic membrane, disruption of the proton motive force, electron flow, active transport mechanisms, and coagulation of cell composition (80).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [80]
The 'Dietary phytochemicals on weaning pig health' section (page unavailable) says phytochemicals can enter bacterial membranes and cause intracellular materials to leak, supporting the membrane-disturbance part. It does not describe disruption of the proton motive force, electron flow or active transport, or coagulation of cell contents; the 'Plant-derived phytochemicals as antibiotic alternatives' section also says their mechanisms are not clearly understood. (LLM, conf=0.86)
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Research works printed but not linked: 3

[101]Fernandez Miyakawa M (2016) Impact of dietary tannins on rumen microbiota of bovines. In: 2nd international symposium on alternatives to antibiotics, OIE, Paris, 12–15 Dec 2016
[128]Redondo L, Redondo E, Diaz Carrasco J (2016) Selected polyphenols as growth promoter. In: 2nd international symposium on alternatives to antibiotics, OIE, Paris, 12–15 Dec 2016
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Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction
Hassan, F.-U., Arshad, M. A., Ebeid, H. M., Rehman, M. S.-U., Khan, M. S., Shahid, S., & Yang, C. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.575801 · Cited by 160 · see citing works

Authors: Lillehoj, H., Liu, Y., Calsamiglia, S., Fernandez-Miyakawa, M. E., Chi, F., Cravens, R. L., Oh, S., & Gay, C. G.
Affiliations: Agricultural Research Service (US)
University of California, Davis (US)
Universitat Autònoma de Barcelona (ES)
Corresponding author: Lillehoj, Hyun
ORCID: Lillehoj, Hyun
Liu, Yanhong
Calsamiglia, Sergio
Oh, Sungtaek
Gay, Cyril G.
Venue: Veterinary Research
Publisher: Springer Science and Business Media LLC
Published: 2018-07-31
Volume: 49
Issue: 1
Pages: 76-76
ISSN: 0928-4249 (ISSN-L)
1297-9716
DOI: 10.1186/s13567-018-0562-6
PMC: PMC6066919
OpenAlex: W2885005744
Cited by: 515
References: 141
Citations by year: 2026: 64 · 2025: 67 · 2024: 74 · 2023: 74 · 2022: 87 · 2021: 60 · 2020: 72 · 2019: 16
FWCI: 4.44
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Veterinary Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Americanae (AECID Library) (publishedVersion, other-oa)
HAL (submittedVersion, other-oa)
Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Greater South Information System
Funders: U.S. Department of Agriculture
Agricultural Research Service
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords: phytochemicals, antibiotic alternatives, antibiotic growth promoters, animal health, poultry, pigs, ruminants, antibiotic resistance, sustainable livestock production, host health
MeSH terms: Animals, Animal Diseases, Animal Feed, Animal Husbandry, Anti-Bacterial Agents, France, Poultry, Livestock, Phytochemicals

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Phytochemicals as antibiotic alternatives to promote growth and enhance host health

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