The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Regulated transcription of Clostridium difficile toxin genes
Open accessAbstract
The Clostridium difficile toxA and toxB genes, encoding cytotoxic and enterotoxic proteins responsible for antibiotic‐associated colitis and pseudomembranous colitis, were shown to be transcribed both from gene‐specific promoters and from promoters of upstream genes. However, the gene‐specific transcripts represented the majority of tox gene mRNAs. The 5′ ends of these mRNAs were shown to correspond to DNA sequences that had promoter activity when fused to the Escherichia coli β‐glucuronidase (gusA) gene and introduced into C. perfringens. The appearance of tox mRNA in C. difficile was repressed during exponential growth phase but increased substantially as cells entered stationary phase. When glucose or other rapidly metabolizable sugars were present in the medium, the stationary phase‐associated induction was inhibited, indicating that the toxin genes are subject to a form of catabolite repression. This glucose effect was general to many toxinogenic strains having varying levels of toxin production.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Experiments in molecular genetics
Miller, J. H. (1972) · Medical Entomology and Zoology · Cited by 27,157
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
Marmur, J. (1961) · Journal of Molecular Biology · doi:10.1016/s0022-2836(61)80047-8 · Cited by 11,545
Studies on transformation of Escherichia coli with plasmids
Hanahan, D. (1983) · Journal of Molecular Biology · doi:10.1016/s0022-2836(83)80284-8 · Cited by 11,157
Phylogenetic relationships among ascomycetes: evidence from an RNA polymerse II subunit
Liu, Y. J., Whelen, S., & Hall, B. D. (1999) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026092 · Cited by 3,751
High efficiency transformation of E.coli by high voltage electroporation
Dower, W. J., Miller, J. F., & Ragsdale, C. W. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.13.6127 · Cited by 2,809
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.
Tabor, S., & Richardson, C. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.4767 · Cited by 2,241
[99] Determination of nucleic acids in tissues by pentose analysis
Schneider, W. C. (1957) · Methods in Enzymology · doi:10.1016/s0076-6879(57)03442-4 · Cited by 1,883
Glucosylation of Rho proteins by Clostridium difficile toxin B
Just, I., Selzer, J., Wilm, M., Eichel-Streiber, C. V., Mann, M., & Aktories, K. (1995) · Nature · doi:10.1038/375500a0 · Cited by 1,032
The sigma 70 family: sequence conservation and evolutionary relationships
Lonetto, M., Gribskov, M., & Gross, C. A. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.12.3843-3849.1992 · Cited by 888
Cited by
Carbon catabolite repression in bacteria: many ways to make the most out of nutrients
Görke, B., & Stülke, J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1932 · Cited by 1,701
Deutscher, J., Francke, C., & Postma, P. W. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00024-06 · Cited by 1,424
Clostridium difficile Toxins: Mechanism of Action and Role in Disease
Voth, D. E., & Ballard, J. D. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.2.247-263.2005 · Cited by 1,104
Theriot, C. M., Koenigsknecht, M. J., Carlson, P. E., Hatton, G. E., Nelson, A. M., Li, B., Huffnagle, G. B., Z. Li, J., & Young, V. B. (2014) · Nature Communications · doi:10.1038/ncomms4114 · Cited by 974
Clostridium difficile infection
Smits, W. K., Lyras, D., Lacy, D. B., Wilcox, M. H., & Kuijper, E. J. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.20 · Cited by 853
Metadata
- Authors
- Dupuy, B., & Sonenshein, A. L.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 27
- Issue
- 1
- Pages
- 107-120
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2076701025
- Cited by
- 289
- References
- 48
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulated transcription of Clostridium difficile toxin genes. https://app.cochat.ai/papers/10.1046/j.1365-2958.1998.00663.x
- The paper
- Dupuy, B., & Sonenshein, A. L. (1998). Regulated transcription of Clostridium difficile toxin genes. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1998.00663.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
