MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake

Horsburgh, Malcolm J.; Wharton, Stephen J.; Cox, Alan G.; Ingham, Eileen; Peacock, Sharon; Foster, Simon J.

doi:10.1046/j.1365-2958.2002.02944.x

Cited by 229Bacterial Genetics and BiotechnologyAntimicrobial Resistance in StaphylococcusFungal and yeast genetics research

MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake

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Horsburgh, Malcolm J., Wharton, Stephen J., Cox, Alan G., Ingham, Eileen, Peacock, Sharon, Foster, Simon J.·2002·Molecular Microbiology

DOI 10.1046/j.1365-2958.2002.02944.x

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Abstract

Summary: The Staphylococcus aureus DtxR‐like protein, MntR, controls expression of the mntABC and mntH genes, which encode putative manganese transporters. Mutation of mntABC produced a growth defect in metal‐depleted medium and increased sensitivity to intracellularly generated superoxide radicals. These phenotypes resulted from diminished uptake of manganese and were rescued by the addition of excess Mn(II). Resistance to superoxide was incompletely rescued by Mn(II) for STE035 ( mntA mntH ), and the strain had reduced virulence in a murine abscess model of infection. Expression of mntABC was repressed by Mn(II) in an MntR‐dependent manner, which contrasts with the expression of mntH that was not repressed in elevated Mn(II) and was decreased in an mntR mutant. This demonstrates that MntR acts as a negative and positive regulator of these loci re‐spectively. PerR, the peroxide resistance regulon repressor, acts with MntR to control the expression of mntABC and manganese uptake. The expression of the PerR‐regulated genes, katA (catalase), ftn (ferritin) and fur (ferric uptake regulator), was diminished in STE031 ( mntR ) when grown in excess Mn(II). Therefore, the control of Mn(II)‐regulated members of the PerR regulon and the Fur protein is modulated by MntR through its control of Mn(II) uptake. The co‐ordinated regulation of metal ion homeostasis and oxidative stress resistance via the regulators MntR, PerR and Fur of S. aureus is discussed.

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Mutation of mntH in S. aureus does not cause appreciable growth defect in metal-depleted media.
“In contrast, mutation of mntH does not lead to an appreciable growth defect in metal-depleted media”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
The S. aureus genome encodes MntABC-type and Nramp-type manganese transporters, both functionally characterized.
“The S. aureus genome encodes MntABC-type (mntABC) and Nramp-type (mntH) manganese transporters, both of which have been functionally characterized.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
In manganese-replete conditions, MntR represses transcription of mntABC.
“In manganese-replete conditions, transcription of mntABC is repressed by MntR.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
Mutation of mntA in S. aureus reduces growth rate in metal-depleted minimal media, reversible by adding manganese.
“Mutation of mntA in S. aureus results in a reduced growth rate in metal-depleted minimal media, a phenotype that is reversible upon addition of manganese.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
Deletion of mntR leads to constitutive transcription of mntABC regardless of manganese levels.
“Deletion of mntR leads to constitutive transcription of mntABC irrespective of manganese levels.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]

MntABC may be the dominant manganese transporter in S. aureus under in vitro conditions.
“suggesting that MntABC may be the dominant manganese transporter in S. aureus under in vitro conditions [144].”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
The transcriptional regulator MntR affects expression of both mntABC and mntH.
“The transcriptional regulator MntR affects expression of both mntABC and mntH.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
In S. aureus strain 8325-4, mutation of mntA, mntH, or mntR alone does not significantly reduce bacterial recovery in a murine skin abscess model.
“In S. aureus, mutation of mntA, mntH, or mntR in the laboratory strain 8325-4 does not lead to a significant reduction in bacterial recovery in a murine skin abscess model.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
S. aureus uses superoxide dismutase-independent mechanisms to detoxify superoxide, which also depend on manganese.
“Additionally, S. aureus employs superoxide dismutase-independent mechanisms to detoxify superoxide, a process that is also dependent on manganese [144].”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
mntABC is negatively regulated by PerR, a manganese and iron-dependent Fur homologue controlling oxidative stress responses.
“In addition to regulation by MntR, mntABC is negatively regulated by PerR, a manganese and iron-dependent Fur homologue that controls responses to oxidative stress [144, 145].”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
Disruption of mntA, mntH, mntR, or both mntA and mntH significantly reduces intracellular survival in human endothelial cells.
“Disruption of mntA, mntH, mntR, or both mntA and mntH also significantly reduces intracellular survival in human endothelial cells [144].”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]
Concurrent inactivation of mntA and mntH significantly decreases bacterial recovery in the murine skin abscess model.
“In contrast, concurrent inactivation of mntA and mntH significantly decreases bacterial recovery in this model.”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [144]

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Self-citation
Characterization of the Role of the Divalent Metal Ion-Dependent Transcriptional Repressor MntR in the Virulence of Staphylococcus aureus
Ando, M., Manabe, Y. C., Converse, P. J., Miyazaki, E., Harrison, R., Murphy, J. R., & Bishai, W. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2584-2590.2003 · Cited by 40 · see citing works

Authors: Horsburgh, M. J., Wharton, S. J., Cox, A. G., Ingham, E., Peacock, S., & Foster, S. J.
Affiliations: University of Sheffield (GB)
University of Leeds (GB)
John Radcliffe Hospital (GB)
Corresponding author: Foster, Simon J.
ORCID: Horsburgh, Malcolm J.
Ingham, Eileen
Peacock, Sharon
Foster, Simon J.
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2002-05-23
Volume: 44
Issue: 5
Pages: 1269-1286
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1046/j.1365-2958.2002.02944.x
OpenAlex: W2154476329
Cited by: 228
References: 65
Citations by year: 2026: 7 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 15 · 2019: 15 · 2018: 11 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 9 · 2013: 14 · 2012: 8
FWCI: 4.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: MntR, PerR, Staphylococcus aureus, manganese uptake, MntH, oxidative stress resistance, fur, kata, ferritin, metal homeostasis, gene expression regulation, virulence
MeSH terms: Animals, Bacterial Proteins, Base Sequence, Endothelium, Vascular, Genes, Bacterial, Herbicides, Homeostasis, Humans, Manganese, Mice, Inbred BALB C, Molecular Sequence Data, Paraquat, Promoter Regions, Genetic, Recombinant Fusion Proteins, Repressor Proteins, Staphylococcus aureus, Superoxides, Transcription Factors, Gene Expression Regulation, Bacterial, Genes, Reporter, Regulon, Mice

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MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake

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