Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis

Diaz-Ochoa, Vladimir E.; Jellbauer, Stefan; Klaus, Suzi; Raffatellu, Manuela

doi:10.3389/fcimb.2014.00002

Cited by 129Trace Elements in HealthIron Metabolism and DisordersGut microbiota and health

Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis

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Diaz-Ochoa, Vladimir E., Jellbauer, Stefan, Klaus, Suzi, Raffatellu, Manuela·2014·Frontiers in Cellular and Infection Microbiology

DOI 10.3389/fcimb.2014.00002PMC PMC3900919

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Abstract

Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further reduce the availability of metal nutrients by activating epithelial cells and recruiting neutrophils, both of which release metal-binding proteins with antimicrobial function. Microorganisms, in turn, have evolved sophisticated systems to overcome these limitations and acquire the metal ions essential for their growth. Here we review some of the mechanisms employed by the host and by pathogenic microorganisms to compete for transition metal ions, with a discussion of how evading "nutritional immunity" benefits pathogens. Furthermore, we provide new insights on the mechanisms of host-microbe competition for metal ions in the mucosa, particularly in the inflamed gut.

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S100 proteins can be induced by IL-17 and IL-22, exert pro-inflammatory activity, and may promote chemotaxis of PMN.
“In addition, S100 proteins can be induced by IL-17 and IL-22, and S100 proteins exert pro-inflammatory activity and may promote chemotaxis of PMN (233, 244).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [244]
S100A8 and S100A9 form the heterodimeric complex calprotectin, which is mainly expressed by PMN.
“Two of these proteins, S100A8 and S100A9, form a heterodimeric complex named calprotectin and are mainly expressed by PMN.”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [244]

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“…effect against such infections via acidification of the microbe containing phagosome, but also by altering the cellular distribution of divalent metals such as zinc, manganese or iron which all play decisive role in host–pathogen interaction (Hood and Skaar, 2012; Diaz-Ochoa et al., 2014).”
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Authors: Diaz-Ochoa, V. E., Jellbauer, S., Klaus, S., & Raffatellu, M.
Affiliations: University of California, Irvine (US)
Corresponding author: Raffatellu, Manuela
ORCID: Diaz-Ochoa, Vladimir E.
Raffatellu, Manuela
Venue: Frontiers in Cellular and Infection Microbiology
Publisher: Frontiers Media SA
Published: 2014
Volume: 4
Pages: 2-2
ISSN: 2235-2988 (ISSN-L)
DOI: 10.3389/fcimb.2014.00002
PMC: PMC3900919
OpenAlex: W1983281945
Cited by: 129
References: 143
Citations by year: 2026: 4 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 16 · 2016: 17 · 2015: 20 · 2014: 8
FWCI: 2.31
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Institute of General Medical Sciences (T32GM008620)
National Institute of Allergy and Infectious Diseases (AI083663, R01AI083663, U54AI065359)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: transition metal ions, nutritional immunity, mucosal immunity, intestinal inflammation, metal-binding proteins, antimicrobial peptides, neutrophils, epithelial cells, pathogenic microorganisms, micronutrients
MeSH terms: Animals, Bacteria, Fungi, Humans, Ions, Metals, Mucous Membrane, Virulence, Immunity, Mucosal, Host-Pathogen Interactions

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

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Record

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