The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Identification of a Gliadin T‐Cell Epitope in Coeliac Disease: General Importance of Gliadin Deamidation for Intestinal T‐Cell Recognition
Abstract
Coeliac disease probably results from a T‐cell response to wheat gliadin and is associated to HLA‐DQ2. No gliadin epitopes recognized by intestinal T cells have yet been identified, limiting our understanding of the pathogenesis. Gut‐lesion‐derived DQ2‐restricted T cells from coeliac disease patients were used to identify an epitope within a purified γ‐type gliadin. The structure of the epitope was characterized by mass spectrometry and verified by synthesis. The epitope (QPQQSFPEQQ) results from deamidation of a distinct glutamine in the native structure. This deamidation is important for binding to DQ2 and T‐cell recognition. Other gut‐derived T cells fail to recognize the epitope, although deamidation of unfractionated gliadin enhances the response of all gut‐derived DQ2‐restricted T cells isolated from several patients. Several DQ2‐restricted T‐cell epitopes exist, but for all of them deamidation of glutamine residues appears to be critical for creation of active epitopes. Native gliadin has few negatively charged residues but is very rich in glutamine. After deamidation gliadin becomes a rich source of DQ2 epitopes thus providing a link between DQ2, gliadin and coeliac disease. The necessity for modification may have general immunological relevance.
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Cited by
Husby, S., Koletzko, S., Korponay‐Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., et al. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31821a23d0 · Cited by 2,683
Coeliac disease: dissecting a complex inflammatory disorder
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Self-citationKIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Li, J., Zaslavsky, M., Su, Y., Guo, J., Sikora, M. J., van Unen, V., Christophersen, A., Chiou, S.-H., Chen, L., Li, J., et al. (2022) · Science · doi:10.1126/science.abi9591 · Cited by 249
Metadata
- Authors
- Sjöström, Lundin, Molberg, Körner, Mcadam, Anthonsen, Quarsten, Norén, Roepstorff, Thorsby, & Sollid
- Venue
- Scandinavian Journal of Immunology
- Publisher
- Wiley
- Published
- 1998-08
- Volume
- 48
- Issue
- 2
- Pages
- 111-115
- ISSN
- 0300-9475 (ISSN-L)
- 1365-3083
- OpenAlex
- W1990569913
- Cited by
- 269
- References
- 20
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sjöström, Lundin, Molberg, Körner, Mcadam, Anthonsen, Quarsten, Norén, Roepstorff, Thorsby, & Sollid. (1998). Identification of a Gliadin T‐Cell Epitope in Coeliac Disease: General Importance of Gliadin Deamidation for Intestinal T‐Cell Recognition. Scandinavian Journal of Immunology. https://doi.org/10.1046/j.1365-3083.1998.00397.x
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