The human β‐globin locus control region: A center of attraction

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Steroid hormone receptors: Many Actors in search of a plot

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

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Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

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A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

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The LIM‐only protein Lmo2 is a bridging molecule assembling an erythroid, DNA‐binding complex which includes the TAL1, E47, GATA‐1 and Ldb1/NLI proteins

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A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

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Multilineage gene expression precedes commitment in the hemopoietic system.Preprint

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Histone methylation versus histone acetylation: new insights into epigenetic regulation

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Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development

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Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

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Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

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Krüppel-like Factors: Three Fingers in Many Pies

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The "beta-like-globin" gene domain in human erythroid cells.

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Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

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Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin

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Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

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Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

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Looping versus linking: toward a model for long-distance gene activationPreprint

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Transcription complex stability and chromatin dynamics in vivo

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A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.Preprint

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Functional Synergy and Physical Interactions of the Erythroid Transcription Factor GATA-1 with the Krüppel Family Proteins Sp1 and EKLF

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Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division.

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Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

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Insulators and Boundaries: Versatile Regulatory Elements in the Eukaryotic Genome

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The Molecular Basis of Blood Diseases

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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

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Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

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Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus

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Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.Preprint

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Intergenic transcription and transinduction of the human β-globin locusPreprint

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Heterochromatin Effects on the Frequency and Duration of LCR-Mediated Gene Transcription

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Developmental regulation of β-globin gene switching

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Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locusPreprint

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A SWI/SNF–Related Chromatin Remodeling Complex, E-RC1, Is Required for Tissue-Specific Transcriptional Regulation by EKLF In Vitro

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Chromosome Territories, Interchromatin Domain Compartment, and Nuclear Matrix: An Integrated View of the Functional Nuclear Architecture

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The world according to Maf

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CREB-binding protein and p300: molecular integrators of hematopoietic transcription

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RNA polymerase II elongation through chromatin

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A Functional Enhancer Suppresses Silencing of a Transgene and Prevents Its Localization Close to Centromeric Heterochromatin

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Rapid reprogramming of globin gene expression in transient heterokaryons

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Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

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Human transcription factor USF stimulates transcription through the initiator elements of the HIV‐1 and the Ad‐ML promoters.

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Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain

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β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region

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Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.Preprint

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The role of EKLF in human beta-globin gene competition.Preprint

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Transcription of the hypersensitive site HS2 enhancer in erythroid cells.

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Multivalent DNA Binding Complex Generated by Small Maf and Bach1 as a Possible Biochemical Basis for β-Globin Locus Control Region Complex

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The Effect of Distance on Long-Range Chromatin Interactions

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The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus

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Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

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Self-Association of the Erythroid Transcription Factor GATA-1 Mediated by Its Zinc Finger Domains

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Looping, Linking, and Chromatin Activity

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Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice

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Distinct Mechanisms Control RNA Polymerase II Recruitment to a Tissue-Specific Locus Control Region and a Downstream Promoter

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Analysis of Mice Containing a Targeted Deletion of β-Globin Locus Control Region 5′ Hypersensitive Site 3

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The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells

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Activation of the beta-globin locus control region precedes commitment to the erythroid lineage.

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Mechanisms of developmental control of transcription in the murine α- and β-globin lociPreprint

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Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

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Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes

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Positions of Potential:Nuclear Organization and Gene Expression

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Activation of β-major globin gene transcription is associated with recruitment of NF-E2 to the β-globin LCR and gene promoter

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酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング

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Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region

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Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

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Histone Acetylation Is Required to Maintain the Unfolded Nucleosome Structure Associated with Transcribing DNA

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The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.Preprint

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Role of Gene Order in Developmental Control of Human γ- and β-Globin Gene Expression

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FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin Genes

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Direct interaction of NF-E2 with hypersensitive site 2 of the β-globin locus control region in living cells

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Do LCRs Open Chromatin Domains?

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Long range interaction of cis‐DNA elements mediated by architectural transcription factor Bach1

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Intergenic Transcription in the Human β-Globin Gene Cluster

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Hypersensitive Site 2 Specifies a Unique Function within the Human β-Globin Locus Control Region To Stimulate Globin Gene Transcription

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Developmental Specificity of the Interaction between the Locus Control Region and Embryonic or Fetal Globin Genes in Transgenic Mice with an HS3 Core Deletion

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Expression of the chicken GATA factor family during early erythroid development and differentiation

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Evidence that the transcription factor USF is a component of the human beta-globin locus control region heteromeric protein complex.

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Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the β-Globin Locus Control Region

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Context-dependent EKLF responsiveness defines the developmental specificity of the human ɛ-globin gene in erythroid cells of YAC transgenic micePreprint

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Role of gene order in developmental control of human gamma- and beta-globin gene expression.

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Transcription of the HS2 Enhancer toward a cis-Linked Gene Is Independent of the Orientation, Position, and Distance of the Enhancer Relative to the Gene

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Visualization and analysis of unfolded nucleosomes associated with transcribing chromatin

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Nucleosome fractionation by mercury affinity chromatography. Contrasting distribution of transcriptionally active DNA sequences and acetylated histones in nucleosome fractions of wild-type yeast cells and cells expressing a histone H3 gene altered to encode a cysteine 110 residue.

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Phosphorylation in Transcription: The CTD and More

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Developmental regulation of eukaryotic gene loci

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