CoChat
Sign Up
Cited by 37

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Effects of macrophage‐colony‐stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor

Sasaki, Atsushi, Yokoo, Hideaki, Naito, Makoto, Kaizu, Chikako, Shultz, Leonard D, Nakazato, Yoichi·2000·Neuropathology
DOI 10.1046/j.1440-1789.2000.00286.x
Open this paper in CoChat — free account

Abstract

Macrophage‐colony‐stimulating factor (M‐CSF) regulates the survival, proliferation and differentiation of the mononuclear phagocyte lineage. Osteopetrotic (op/op) mice defective in producing functional M‐CSF were used in order to investigate the role of M‐CSF on the development of microglia and brain macrophages and the expression of scavenger receptor (SR). Adult op/op and littermate mice at 10–47 weeks of age were investigated by immunohistochemistry with a panel of monoclonal antibodies (F4/80, Mac‐1, anti‐major histocompatibility complex (MHC) class II and anti‐SR), electron microscopy and reverse transcriptase–polymerase chain reaction (RT‐PCR). Microglia were weakly immunolabeled with F4/80 and Mac‐1 in op/op and littermate mice, but the number of microglia in op/op mice was reduced in the cerebrum, cerebellum and brainstem compared with that of normal littermates. The numbers of Mac‐1‐positive microglia in op/op mice was 39% (pons) and 30% (cerebellar cortex) lower than that in normal littermates (P< 0.05). In addition, the microglia cell processes in op/op mice were often shorter than those in control mice. In op/op and littermate mice, both MHC class II and SR were present in perivascular cells and macrophages of the leptomeninx and choroid plexus. Ultrastructurally, perivascular cells appeared to be immature, since their cytoplasm was narrow and contained few inclusion bodies compared with those of control mice. Reverse transcriptase–polymerase chain reaction showed a weak expression for SR mRNA in the brains of op/op mice as well as littermate mice. These results indicate that microglia are partly dependent on M‐CSF for their proliferation and differentiation and that M‐CSF has no significant effect on the expression of SR in the physiological brain. The study also suggests that M‐CSF affects the maturation of perivascular cells at the ultrastructural level.

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1440-1789.2000.00286.x

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 4 references

Research works printed but not linked: 32

  1. Del Rio‐Hortega P., 1932, Cytology and Cellular Pathology of the Nervous System, 481
  2. 10.1002/glia.440010502 · DOI
  3. 10.1002/glia.440070105 · DOI
  4. 10.1016/0166-2236(96)10049-7 · DOI · Paper page
  5. 10.1002/jnr.490220114 · DOI
  6. 10.1097/00005072-199205000-00009 · DOI
  7. 10.1007/BF00334675 · DOI · Paper page
  8. Kodama T, 1990, Type I macrophage scavenger receptor contains alpha‐helical and X collagen‐like coiled coils., Nature, 343, 531, 10.1038/343531a0 · DOI
  9. 10.1111/j.1365-2990.1992.tb00761.x · DOI
  10. Naito M, 1991, Abnormal differentiation of tissue macrophage populations in ‘osteopetrosis’ (op) mice defective in the production of macrophage colony‐stimulating factor (M‐CSF) or CSF‐1., Am J Pathol, 139, 657
  11. Cecchini MG, 1994, Role of colonystimulating factor‐1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse., Development, 120, 1357, 10.1242/dev.120.6.1357 · DOI
  12. Takahashi K, 1994, The role of macrophage colony‐stimulating factor in hepatic glucan‐induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony‐stimulating factor., Am J Pathol, 144, 1381
  13. 10.1073/pnas.87.12.4828 · DOI · Paper page
  14. Qiao JH, 1997, Role of macrophage‐colony stimulating factor in atherosclerosis: studies of osteopetrotic mice., Am J Pathol, 150, 1687
  15. 10.1002/(SICI)1098-2795(199701)46:1<85::AID-MRD13>3.0.CO;2-2 · DOI
  16. Giulian D, 1988, Colony stimulating factors as promotors of ameboid microglia., J Neurosci, 8, 4707, 10.1523/JNEUROSCI.08-12-04707.1988 · DOI
  17. 10.1016/0006-8993(90)90317-5 · DOI
  18. 10.1002/jnr.490300412 · DOI
  19. Witmer‐Pack MD, 1993, Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse., J Cell Sci, 104, 1021, 10.1242/jcs.104.4.1021 · DOI · Paper page
  20. Wegiel J, 1994, Microglial cells in the brain of mouse with severe deficits of macrophages (op/op mice)., Brain Pathol, 4, 388
  21. 10.1084/jem.180.2.705 · DOI
  22. Sawada M., 1995, Developmental origin and multi‐functional subtypes of microglia (in Japanese)., Saibo, 27, 193
  23. Liu W, 1994, Macrophage colony‐stimulating factor mediates astrocyte‐induced microglial ramification in human fetal central nervous system culture., Am J Pathol, 145, 48
  24. 10.1002/(SICI)1097-0185(199703)247:3<307::AID-AR2>3.0.CO;2-R · DOI
  25. 10.1111/j.1440-1827.1996.tb03528.x · DOI
  26. 10.1007/BF01952574 · DOI
  27. 10.1016/0165-5728(89)90087-8 · DOI
  28. 10.1002/eji.1830170909 · DOI
  29. Lee SC, 1993, Macrophage colony‐stimulating factor in human fetal astrocytes and microglia: Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia., J Immunol, 150, 594, 10.4049/jimmunol.150.2.594 · DOI
  30. Naito M, 1991, Tissue distribution, intracellular localization, and in vitro expression of bovine scavenger receptor., Am J Pathol, 139, 1411
  31. 10.1016/0009-9120(92)80018-C · DOI
  32. 10.1073/pnas.94.10.5296 · DOI

Cited by

Sorted by citations

See all 37

Metadata

Authors
Sasaki, A., Yokoo, H., Naito, M., Kaizu, C., Shultz, L. D., & Nakazato, Y.
Venue
Neuropathology
Publisher
Wiley
Published
2000-06
Volume
20
Issue
2
Pages
134-142
ISSN
  • 0919-6544
  • 1440-1789
DOI
10.1046/j.1440-1789.2000.00286.x
Cited by
37
References
4
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 572 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review