Cited by 156Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

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Localization of nAChR subunit mRNAs in the brain of Macaca mulatta

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Han, Zhi‐Yan, Le Novère, Nicolas, Zoli, Michele, Hill, Joseph A., Champtiaux, Nicolas, Changeux, Jean‐Pierre·2000·European Journal of Neuroscience

DOI 10.1046/j.1460-9568.2000.00262.x

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Abstract

We present here a systematic mapping of nAChR subunit mRNAs in Macaca mulatta brain. A fragment, from the transmembrane segments MIII to MIV of Macaca neuronal nAChR subunits was cloned, and shown to exhibit high identity (around 95%) to the corresponding human subunits. Then, specific oligodeoxynucleotides were synthesized for in situ hybridization experiments. Both alpha4 and beta2 mRNA signals were widely distributed in the brain, being stronger in the thalamus and in the dopaminergic cells of the mesencephalon. Most brain nuclei displayed both alpha4 and beta2 signals with the exception of some basal ganglia regions and the reticular thalamic nucleus which were devoid of alpha4 signal. alpha6 and beta3 mRNA signals were selectively concentrated in the substantia nigra and the medial habenula. The strongest signals for alpha3 or beta4 mRNAs were found in the epithalamus (medial habenula and pineal gland), whereas there were no specific alpha3 or beta4 signals in mesencephalic dopaminergic nuclei. alpha5 and alpha7 mRNA signals were found in several brain areas, including cerebral cortex, thalamus and substantia nigra, although at a lower level than alpha4 and beta2. The distribution of alpha3, alpha4, alpha5, alpha6, alpha7, beta2, beta3 and beta4 subunit mRNAs in the monkey is substantially similar to that observed in rodent brain. Surprisingly, alpha2 mRNA signal was largely distributed in the Macaca brain, at levels comparable with those of alpha4 and beta2. This observation represents the main difference between rodent and Macaca subunit mRNA distribution and suggests that, besides alpha4beta2*, alpha2beta2* nAChRs constitute a main nAChR isoform in primate brain.

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Authors: Han, Z., Le Novère, N., Zoli, M., Hill, J. A., Champtiaux, N., & Changeux, J.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Iowa (US)
Corresponding author: Changeux, Jean‐Pierre
ORCID: Han, Zhi‐Yan
Hill, Joseph A.
Champtiaux, Nicolas
Changeux, Jean‐Pierre
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2000-10
Volume: 12
Issue: 10
Pages: 3664-3674
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1046/j.1460-9568.2000.00262.x
OpenAlex: W2047331648
Cited by: 156
References: 78
Citations by year: 2026: 2 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 18 · 2014: 6 · 2013: 9 · 2012: 9
FWCI: 2.17
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 449 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Funders: Fondation Simone et Cino Del Duca
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, rhesus monkeys, primate brain, alpha2 subunit, alpha4beta2 nAChR, thalamus, substantia nigra, medial habenula, dopaminergic neurons, alpha7 subunit, alpha3 subunit, alpha5 subunit, alpha6 subunit, beta3 subunit, beta4 subunit, mRNA localization
MeSH terms: Animals, Brain, Brain Chemistry, Cloning, Molecular, Cytoplasm, Macaca mulatta, Neurons, Receptors, Nicotinic, RNA, Messenger

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Localization of nAChR subunit mRNAs in the brain of Macaca mulatta

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