Structural and functional diversity of native brain neuronal nicotinic receptors
Open accessAbstract
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharmacological and functional properties arise from the wide range of different subunit combinations making up distinctive subtypes. nAChRs are involved in many physiological functions in the central and peripheral nervous systems, and are the targets of the widely used drug of abuse nicotine. In addition to tobacco dependence, changes in their number and/or function are associated with neuropsychiatric disorders, ranging from epilepsy to dementia. Although some of the neural circuits involved in the acute and chronic effects of nicotine have been identified, much less is known about which native nAChR subtypes are involved in specific physiological functions and pathophysiological conditions. We briefly review some recent findings concerning the structure and function of native nAChRs, focusing on the subtypes identified in the mesostriatal and habenulo-interpeduncular pathways, two systems involved in nicotine reinforcement and withdrawal. We also discuss recent findings concerning the effect of chronic nicotine on the expression of native subtypes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
nAChR upregulation varies by receptor subtype, brain region, and contingency of nicotine administration.
“Relevant to the understanding of the neuroadaptations produced by nicotine is the fact that nAChR upregulation differs among receptor subtypes, varies among brain regions for the same subtype, and even depends on the contingency of nicotine administration [9, 90, 93].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [9]
Nicotine generally acts in the central nervous system through nicotinic acetylcholine receptors.
“Nicotine generally exerts its effects in the central nervous system (CNS) via an interaction at nicotinic acetylcholine receptors (nAChRs) (Albuquerque et al., 2009;Gotti et al., 2009).”
From Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization (2010) · cites this paper as Gotti et al., 2009
Cites
Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724 · see citing works
Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution
Unwin, N. C. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.031 · Cited by 1,661 · see citing works
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197 · see citing works
Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044 · see citing works
Neuronal nicotinic receptors: from structure to pathology
Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970 · see citing works
Self-citationBrain nicotinic acetylcholine receptors: native subtypes and their relevance
Gotti, C., Zoli, M., & Clementi, F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.07.004 · Cited by 882 · see citing works
Self-citationAcetylcholine beyond neurons: the non‐neuronal cholinergic system in humans
Wessler, I. K., & Kirkpatrick, C. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.185 · Cited by 855 · see citing works
Nicotinic Receptors at the Amino Acid Level
Corringer, P., Novère, N. G. L., & Changeux, J. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.431 · Cited by 823 · see citing works
Celie, P. H. N., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., & Sixma, T. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00115-1 · Cited by 781 · see citing works
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674 · see citing works
Self-citationX-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
Bocquet, N., Nury, H., Baaden, M., Poupon, C. L., Changeux, J., Delarue, M. H., & Corringer, P. (2008) · Nature · doi:10.1038/nature07462 · Cited by 674 · see citing works
Elgoyhen, A. B., Vetter, D. E., Katz, E., Rothlin, C. V., Heinemann, S. F., & Boulter, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051622798 · Cited by 673 · see citing works
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
Hilf, R. J. C., & Dutzler, R. (2008) · Nature · doi:10.1038/nature06717 · Cited by 665 · see citing works
Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., & Bourne, Y. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600828 · Cited by 643 · see citing works
Nicotinic acetylcholine receptors and the regulation of neuronal signalling
Dajas‐Bailador, F., & Wonnacott, S. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.04.006 · Cited by 618 · see citing works
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J.-P., Evrard, A., Cazala, P., Cormier, A., Mameli-Engvall, M., et al. (2005) · Nature · doi:10.1038/nature03694 · Cited by 566 · cited 1× · see citing works
“and/or α6 subunits in the ventral midbrain [70] [71] have shown that nAChRs in the”
BackgroundNicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551 · see citing works
Jensen, A. A., Frølund, B., Liljefors, T., & Krogsgaard‐Larsen, P. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040219e · Cited by 541 · see citing works
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
Hilf, R. J. C., & Dutzler, R. (2008) · Nature · doi:10.1038/nature07461 · Cited by 526 · see citing works
Recent advances in Cys-loop receptor structure and function
Sine, S. M., & Engel, A. G. (2006) · Nature · doi:10.1038/nature04708 · Cited by 521 · see citing works
Champtiaux, N., Gotti, C., Cordero‐Erausquin, M., David, D. J. P., Przybylski, C., Léna, C., Clementi, F., Moretti, M., Rossi, F., Novère, N. G. L., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07820.2003 · Cited by 505 · see citing works
Self-citationPentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
Cooper, E., Couturier, S., & Ballivet, M. (1991) · Nature · doi:10.1038/350235a0 · Cited by 470 · see citing works
PICCIOTTO, M., ADDY, N., MINEUR, Y., & BRUNZELL, D. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.005 · Cited by 451 · cited 5× · see citing works
“unresponsive to agonists (reviewed in [30]).”
BackgroundInfluentialDiversity of vertebrate nicotinic acetylcholine receptors
Millar, N. S., & Gotti, C. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.041 · Cited by 441 · see citing works
Self-citationAlternate stoichiometries of α4β2 nicotinic acetylcholine receptors
Nelson, M. E., Kuryatov, A., Choi, C. H., Zhou, Y., & Lindstrom, J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.332 · Cited by 422 · see citing works
Zoli, M., Moretti, M., Zanardi, A., McIntosh, J. M., Clementi, F., & Gotti, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-08785.2002 · Cited by 407 · see citing works
Self-citationIdentification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04461.1998 · Cited by 401 · see citing works
Self-citationFunctional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 397 · see citing works
Identification of four classes of brain nicotinic receptors using beta2 mutant mice.
Zoli, M., Léna, C., Picciotto, M. R., & Changeux, J. (1998) · PubMed Central · doi:10.1523/jneurosci.18-12-04461.1996 · Cited by 387 · see citing works
Self-citationLe Novere, N., Zoli, M., & Changeux, J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01206.x · Cited by 385 · see citing works
Self-citationIncreased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies
Perry, D. C., Dávila-Garcı́a, M. I., Stockmeier, C. A., & Kellar, K. J. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38304-1 · Cited by 362 · see citing works
Desensitization of nicotinic ACh receptors: shaping cholinergic signaling
GINIATULLIN, R., NISTRI, A., & YAKEL, J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.04.009 · Cited by 357 · see citing works
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
Schuller, H. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2590 · Cited by 355 · see citing works
Ca2+ permeability of nicotinic acetylcholine receptors
Fucile, S. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.08.006 · Cited by 320 · see citing works
Anand, R., Conroy, W. G., Schoepfer, R., Whiting, P. J., & Lindstrom, J. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99147-7 · Cited by 315 · see citing works
Pons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J. M., Changeux, J. P., Maskos, U., & Fratta, W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-08.2008 · Cited by 312 · see citing works
Salas, R., Sturm, R., Boulter, J., & De Biasi, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4934-08.2009 · Cited by 310 · see citing works
Conroy, W. G., & Berg, D. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4424 · Cited by 297 · see citing works
Moroni, M., Zwart, R., Sher, E., Cassels, B. K., & Bermúdez, I. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023044 · Cited by 286 · see citing works
Lecourtier, L., & Kelly, P. H. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.004 · Cited by 283 · see citing works
Heterogeneity and complexity of native brain nicotinic receptors
Gotti, C., Moretti, M., Gaimarri, A., Zanardi, A., Clementi, F., & Zoli, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.05.023 · Cited by 282 · see citing works
Self-citationEgleton, R. D., Brown, K. C., & Dasgupta, P. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.12.006 · Cited by 274 · see citing works
Nicotine upregulates its own receptors through enhanced intracellular maturation
Sallette, J., Pons, S., Devillers-Thiery, A., Soudant, M., Prado de Carvalho, L., Changeux, J.-P., & Corringer, P. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.029 · Cited by 261 · see citing works
Nicotine addiction: the possible role of functional upregulation
Buisson, B., & Bertrand, D. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01979-9 · Cited by 254 · see citing works
Exley, R., Clements, M. A., Hartung, H., McIntosh, J. M., & Cragg, S. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301617 · Cited by 242 · see citing works
Salas, R., Pieri, F., & De Biasi, M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1939-04.2004 · Cited by 226 · see citing works
Staley, J. K., Krishnan-Sarin, S., Cosgrove, K. P., Krantzler, E., Frohlich, E., Perry, E., Dubin, J. A., Estok, K., Brenner, E., Baldwin, R. M., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0546-06.2006 · Cited by 223 · cited 1× · see citing works
“have high β2* receptor levels for at least seven days after stopping smoking [123].”
BackgroundGrady, S. R., Moretti, M., Zoli, M., Marks, M. J., Zanardi, A., Pucci, L., Clementi, F., & Gotti, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5121-08.2009 · Cited by 222 · see citing works
Self-citationPicciotto, M. R., Caldarone, B. J., Brunzell, D. H., Zachariou, V., Stevens, T. R., & King, S. L. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00161-9 · Cited by 221 · see citing works
Khiroug, S. S., Harkness, P. C., Lamb, P. W., Sudweeks, S. N., Khiroug, L. S., Millar, N. S., & Yakel, J. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013847 · Cited by 215 · see citing works
Zwart, R., & Vijverberg, H. P. M. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.6.1124 · Cited by 215 · see citing works
Cui, C., Booker, T. K., Allen, R. S., Grady, S. R., Whiteaker, P., Marks, M. J., Salminen, O., Tritto, T., Butt, C. M., Allen, W. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11045.2003 · Cited by 213 · see citing works
A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit
Sgard, F., Charpantier, E., Bertrand, S., Walker, N., Caput, D., Graham, D., Bertrand, D., & Besnard, F. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.150 · Cited by 212 · see citing works
The Nicotinic Acetylcholine Receptor Subunit α5 Mediates Short-Term Effects of Nicotine in Vivo
Salas, R., Orr‐Urtreger, A., Broide, R. S., Beaudet, A. L., Paylor, R. E., & Biasi, M. D. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.5.1059 · Cited by 200 · see citing works
Alkondon, M., & Albuquerque, E. X. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45007-3 · Cited by 197 · see citing works
Drenan, R. M., Grady, S. R., Whiteaker, P., McClure-Begley, T., McKinney, S., Miwa, J. M., Bupp, S., Heintz, N., McIntosh, J. M., Bencherif, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.009 · Cited by 197 · see citing works
Tapia, L., Kuryatov, A., & Lindstrom, J. M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030445 · Cited by 196 · see citing works
Roles of Accessory Subunits in α4β2* Nicotinic Receptors
Kuryatov, A., Onksen, J., & Lindstrom, J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046789 · Cited by 195 · see citing works
Martin-Ruiz, C. M., COURT, J. A., Molnár, E., Lee, M., Gotti, C., Mamalaki, A., Tsouloufis, T., Tzartos, S. J., Ballard, C. G., Perry, R. H., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731635.x · Cited by 194 · see citing works
Self-citationKawashima, K., & Fujii, T. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fm0070073 · Cited by 184 · see citing works
Liu, Q., Huang, Y., Xue, F., Simard, A. R., DeChon, J., Li, G., Zhang, J., Lucero, L. M., Wang, M., Sierks, M. R., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3952-08.2009 · Cited by 182 · see citing works
Celie, P. H. N., Klaassen, R. V., van Rossum-Fikkert, S. E., van Elk, R., van Nierop, P., Smit, A. B., & Sixma, T. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414476200 · Cited by 182 · see citing works
Human α4β2 Acetylcholine Receptors Formed from Linked Subunits
Zhou, Y., Nelson, M. E., Kuryatov, A., Choi, C., Cooper, J., & Lindstrom, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09004.2003 · Cited by 174 · see citing works
Olale, F., Gerzanich, V., Kuryatov, A., Wang, F., & Lindstrom, J. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37064-8 · Cited by 174 · see citing works
Olale, F., Gerzanich, V., Kuryatov, A., Wang, F., & Lindstrom, J. M. (1997) · PubMed · Cited by 172 · see citing works
Dickinson, J. A., Kew, J. N. C., & Wonnacott, S. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.046623 · Cited by 159 · see citing works
Localization of nAChR subunit mRNAs in the brain of Macaca mulatta
Han, Z., Le Novère, N., Zoli, M., Hill, J. A., Champtiaux, N., & Changeux, J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00262.x · Cited by 156 · see citing works
Self-citationHabenular and interpeduncularis nuclei: shared components in multiple-function networks.
Klemm, W. R. (2004) · PubMed · Cited by 153 · see citing works
Salminen, O., Drapeau, J. A., McIntosh, J. M., Collins, A. C., Marks, M. J., & Grady, S. R. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.031492 · Cited by 149 · see citing works
Xiao, Y., & Kellar, K. J. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.066787 · Cited by 148 · see citing works
Involvement of the α3 Subunit in Central Nicotinic Binding Populations
Whiteaker, P., Peterson, C. G., Xu, W., McIntosh, J. M., Paylor, R. E., Beaudet, A. L., Collins, A. C., & Marks, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02522.2002 · Cited by 145 · see citing works
Assembly and trafficking of nicotinic acetylcholine receptors (Review)
Millar, N. S., & Harkness, P. C. (2008) · Molecular Membrane Biology · doi:10.1080/09687680802035675 · Cited by 142 · see citing works
Mao, D., Perry, D. C., Yasuda, R. P., Wolfe, B. B., & Kellar, K. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05011.x · Cited by 133 · see citing works
Livingstone, P. D., Srinivasan, J., Kew, J. N. C., Dawson, L. A., Gotti, C., Moretti, M., Shoaib, M., & Wonnacott, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06613.x · Cited by 133 · see citing works
Self-citationBarik, J., & Wonnacott, S. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.018184 · Cited by 132 · see citing works
Fowler, C. D., Arends, M. A., & Kenny, P. J. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830c360e · Cited by 131 · see citing works
RIC‐3: a nicotinic acetylcholine receptor chaperone
Millar, N. S. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707661 · Cited by 125 · see citing works
Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
Rezvani, K., Teng, Y., Shim, D., & De Biasi, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-07.2007 · Cited by 113 · see citing works
Marks, M. J., Farnham, D. A., Grady, S. R., & Collins, A. C. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10175-4 · Cited by 112 · see citing works
Lai, A., Parameswaran, N., Khwaja, M., Whiteaker, P., Lindstrom, J. M., Fan, H., McIntosh, J. M., Grady, S. R., & Quik, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.006429 · Cited by 112 · see citing works
Lewis, T., Harkness, P. C., Sivilotti, L. G., Colquhoun, D., & Millar, N. S. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.299bb.x · Cited by 107 · see citing works
Dopamine neurones of the ventral tegmentum project to both medial and lateral habenula
Phillipson, O. T., & PYCOCK, C. (1982) · Experimental Brain Research · doi:10.1007/bf00235766 · Cited by 107 · see citing works
Perry, D. C., Mao, D., Gold, A. B., McIntosh, J. M., Pezzullo, J. C., & Kellar, K. J. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121228 · Cited by 106 · see citing works
Parker, S. L., Fu, Y., McAllen, K., Luo, J., McIntosh, J. M., Lindstrom, J. M., & Sharp, B. M. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.611 · Cited by 105 · see citing works
Kawai, H. D., & Berg, D. K. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00526.x · Cited by 102 · see citing works
Groot‐Kormelink, P. J., Luyten, W. H. M. L., Colquhoun, D., & Sivilotti, L. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15317 · Cited by 100 · see citing works
Drenan, R. M., Nashmi, R., Imoukhuede, P., Just, H., McKinney, S., & Lester, H. A. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.039180 · Cited by 100 · see citing works
Grando, S. A. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fm0070087 · Cited by 99 · see citing works
Han, Z., Zoli, M., Cardona, A., Bourgeois, J., Changeux, J., & Novère, N. G. L. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10659 · Cited by 99 · see citing works
Self-citationBordia, T., Grady, S. R., McIntosh, J. M., & Quik, M. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035998 · Cited by 97 · see citing works
Wang, F., Chen, H., Steketee, J. D., & Sharp, B. M. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301033 · Cited by 97 · see citing works
Sa√±udo-Pe√±a, M. C., Force, M., Tsou, K., Miller, A. S., & Walker, J. M. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199810)30:2 · Cited by 93 · see citing works
Yu, Z. J., & Wecker, L. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63010186.x · Cited by 90 · see citing works
Moretti, M., Vailati, S., Zoli, M., Lippi, G., Riganti, L., Longhi, R., Viegi, A., Clementi, F., & Gotti, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.66.1.85 · Cited by 89 · see citing works
Self-citationRegulation of neuronal nicotinic receptor traffic and expression
Gaimarri, A., Moretti, M., Riganti, L., Zanardi, A., Clementi, F., & Gotti, C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.005 · Cited by 89 · see citing works
Self-citationKedmi, M., Beaudet, A. L., & Orr‐Urtreger, A. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00202.2003 · Cited by 89 · see citing works
Champtiaux, N., & Changeux, J. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007023339247 · Cited by 88 · see citing works
Brown, R. W. B., Collins, A. C., Lindstrom, J. M., & Whiteaker, P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04700.x · Cited by 88 · see citing works
Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype
Walsh, H., Govind, A. P., Mastro, R., Hoda, J. C., Bertrand, D., Vallejo, Y., & Green, W. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m703432200 · Cited by 87 · see citing works
Corringer, P.-J., Sallette, J., & Changeux, J.-P. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2005.12.012 · Cited by 86 · see citing works
Nguyen, H. N., Rasmussen, B. A., & Perry, D. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02482.x · Cited by 83 · see citing works
Moroni, M., Vijayan, R., Carbone, A. L., Zwart, R., Biggin, P. C., & Bermúdez, I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1228-08.2008 · Cited by 81 · see citing works
Girod, R., Crabtree, G. W., Ernstrom, G. G., Ramírez-Latorre, J. A., McGehee, D. S., Turner, J. R., & Role, L. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11331.x · Cited by 81 · see citing works
Nicotinic Acetylcholine Receptors Assembled from the α7 and β3 Subunits
Palma, E., Maggi, L., Barabino, B., Eusebi, F., & Ballivet, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18335 · Cited by 78 · see citing works
Interplay of β2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion
Avale, M. E., Fauré, P., Pons, S., Robledo, P., Deltheil, T., David, D. J. P., Gardier, A. M., Maldonado, R. J., Granon, S., Changeux, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807635105 · Cited by 78 · see citing works
Perez, X. A., Bordia, T., McIntosh, J. M., Grady, S. R., & Quik, M. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048843 · Cited by 77 · see citing works
Glick, S. D., Ramirez, R. L., Livi, J. M., & Maisonneuve, I. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.045 · Cited by 76 · see citing works
Tumkosit, P., Kuryatov, A., Luo, J., & Lindstrom, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027326 · Cited by 73 · see citing works
Gotti, C., Moretti, M., Zanardi, A., Gaimarri, A., Champtiaux, N., Changeux, J., Whiteaker, P., Marks, M. J., Clementi, F., & Zoli, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.015925 · Cited by 71 · see citing works
Self-citationPre‐synaptic dopaminergic compensation after moderate nigrostriatal damage in non‐human primates
Perez, X. A., Parameswaran, N., Huang, L. Z., O’Leary, K. T., & Quik, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05268.x · Cited by 70 · see citing works
Neuronal nicotinic receptors: insights gained from gene knockout an knocking mutant mice
Drago, J., McColl, C. D., Horne, M. K., Finkelstein, D. I., & Ross, S. A. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2259-9 · Cited by 68 · see citing works
Gotti, C., Moretti, M., Meinerz, N. M., Clementi, F., Gaimarri, A., Collins, A. C., & Marks, M. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.045203 · Cited by 68 · see citing works
Self-citationGrilli, M., Parodi, M., Raiteri, M., & Marchi, M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03126.x · Cited by 65 · see citing works
Mugnaini, M., Garzotti, M., Sartori, I., Pilla, M. A., Repeto, P., Heidbreder, C. A., & Tessari, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.008 · Cited by 64 · see citing works
Broadbent, S. D., Groot‐Kormelink, P. J., Krashia, P., Harkness, P. C., Millar, N. S., Beato, M., & Sivilotti, L. G. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026682 · Cited by 60 · see citing works
Son, C. D., Moss, F. J., Cohen, B. N., & Lester, H. A. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.054494 · Cited by 58 · see citing works
Marks, M. J., Whiteaker, P., & Collins, A. C. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.025338 · Cited by 53 · see citing works
Taraschenko, O. D., Shulan, J. M., Maisonneuve, I. M., & Glick, S. D. (2007) · Synapse · doi:10.1002/syn.20396 · Cited by 53 · see citing works
Sweileh, W. M., Wenberg, K., Xu, J., Forsayeth, J., Hardy, S. F., & Loring, R. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00302-2 · Cited by 46 · see citing works
Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation
Nashmi, R., & Lester, H. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.040 · Cited by 43 · see citing works
Quarta, D., Naylor, C. G., Barik, J., Fernandes, C., Wonnacott, S., & Stolerman, I. P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1281-x · Cited by 39 · see citing works
Perez, X. A., O’Leary, K. T., Parameswaran, N., McIntosh, J. M., & Quik, M. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.053801 · Cited by 38 · see citing works
Marks, M. J., Whiteaker, P., Grady, S. R., Picciotto, M. R., McIntosh, J. M., & Collins, A. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00910.x · Cited by 32 · see citing works
Rasmussen, B. A., & Perry, D. C. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.010 · Cited by 32 · see citing works
Maskos, U. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04224.x · Cited by 30 · see citing works
Brašić, J. R., Zhou, Y., Musachio, J. L., Hilton, J., Fan, H. S., Crabb, A. H., Endres, C. J., Reinhardt, M. J., DOĞAN, A. S., Alexander, M., et al. (2009) · Synapse · doi:10.1002/syn.20611 · Cited by 23 · see citing works
Li, T., Gao, W., & Rao, Z. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01183-9 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453 · see citing works
Frahm, S., Ślimak, M. A., Ferrarese, L., Santos-Torres, J., Antolin-Fontes, B., Auer, S., Filkin, S., Pons, S., Fontaine, J.-F., Tsetlin, V., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.013 · Cited by 283 · see citing works
Diversity of native nicotinic receptor subtypes in mammalian brain
Zoli, M., Pistillo, F., & Gotti, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.003 · Cited by 277 · see citing works
Self-citationBasolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction
Sharp, B. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.161 · Cited by 244 · see citing works
Gotti, C., Guiducci, S., Tedesco, V., Corbioli, S., Zanetti, L., Moretti, M., Zanardi, A., Rimondini, R., Mugnaini, M., Clementi, F., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5095-09.2010 · Cited by 226 · see citing works
Self-citationThe habenulo-interpeduncular pathway in nicotine aversion and withdrawal
Antolin-Fontes, B., Ables, J. L., Görlich, A., & Ibañez-Tallon, I. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.019 · Cited by 154 · see citing works
The Nicotinic Acetylcholine Receptor 5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
Bailey, C. D. C., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-10.2010 · Cited by 146 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Prenatal Nicotine Exposure Alters Lung Function and Airway Geometry through α7 Nicotinic Receptors
Wongtrakool, C., Wang, N., Hyde, D. M., Roman, J., & Spindel, E. R. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0028oc · Cited by 147 · see citing works
Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice
Ponzoni, L., Moretti, M., Sala, M., Fasoli, F., Mucchietto, V, Lucini, V, Cannazza, G., Gallesi, G., Castellana, C., Clementi, F., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.06.010 · Cited by 91 · see citing works
Self-citationPidoplichko, V. I., Prager, E. M., Aroniadou-Anderjaska, V., & Braga, M. F. M. (2013) · Journal of Neurophysiology · doi:10.1152/jn.01030.2012 · Cited by 90 · see citing works
Nicotine and endogenous opioids: neurochemical and pharmacological evidence
Hadjiconstantinou, M., & Neff, N. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.010 · Cited by 81 · see citing works
Nicotinic receptor-mediated reduction in l-DOPA-induced dyskinesias may occur via desensitization
Bordia, T., Campos, C., McIntosh, J. M., & Quik, M. (2010) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.162396 · Cited by 82 · see citing works
Namba, M. D., Leyrer-Jackson, J. M., Nagy, E. K., Olive, M. F., & Neisewander, J. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.650785 · Cited by 76 · see citing works
Neocortical layer 5 subclasses: from cellular properties to roles in behavior
Moberg, S., & Takahashi, N. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.1006773 · Cited by 62 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
“Each of these neuronal subpopulations expresses nAChRs of differing subunit compositions and with differing cellular localizations [8,9,51].”
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.606656 · Cited by 63 · see citing works
Nicotine addiction and psychiatric disorders
Kutlu, M. G., Parikh, V., & Gould, T. J. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.08.004 · Cited by 65 · see citing works
Addiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works
Moretti, M., Mugnaini, M., Tessari, M., Zoli, M., Gaimarri, A., Manfredi, I., Pistillo, F., Clementi, F., & Gotti, C. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064071 · Cited by 58 · see citing works
Self-citationHeath, C. J., King, S. L., Gotti, C., Marks, M. J., & Picciotto, M. R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.130 · Cited by 59 · see citing works
Self-citationStoker, A. K., Olivier, B., & Markou, A. (2012) · Behavior Genetics · doi:10.1007/s10519-011-9511-0 · Cited by 40 · see citing works
Visual hallucinations in Parkinson’s disease: spotlight on central cholinergic dysfunction
Ignatavicius, A., Matar, E., & Lewis, S. J. G. (2025) · Brain · doi:10.1093/brain/awae289 · Cited by 32 · see citing works
Moen, J. K., & Lee, A. M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.745783 · Cited by 30 · see citing works
Lavezzi, A. M., Corna, M. F., Alfonsi, G., & Matturri, L. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-11 · Cited by 25 · see citing works
Rennard, S. I., & Daughton, D. M. (2014) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2013.11.002 · Cited by 25 · see citing works
Cano, M., Reynaga, D. D., Belluzzi, J. D., Loughlin, S. E., & Leslie, F. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108308 · Cited by 17 · see citing works
Renda, A., Penty, N., Komal, P., & Nashmi, R. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.019 · Cited by 17 · see citing works
- Authors
- Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., & Zoli, M.
- Affiliations
- University of Milan (IT)
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Gotti, Cecilia
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 78
- Issue
- 7
- Pages
- 703-711
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2040106038
- Semantic Scholar
- 5ecabce85a0060f56df07a736f2684a843dd255a
- Cited by
- 469
- References
- 127
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 21 · 2021: 29 · 2020: 31 · 2019: 20 · 2018: 23 · 2017: 24 · 2016: 30 · 2015: 41 · 2014: 46 · 2013: 47 · 2012: 28
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal nicotinic acetylcholine receptors, nAChR subtypes, ligand-gated ion channels, nicotine, nicotine reinforcement, nicotine withdrawal, mesostriatal pathway, neuropsychiatric disorders, epilepsy, dementia, tobacco dependence
- MeSH terms
- Animals, Brain, Humans, Neural Pathways, Neurons, Nicotine, Protein Conformation, Receptors, Nicotinic, Tobacco Use Disorder, Nicotinic Agonists, Protein Subunits, Protein Multimerization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review