Cited by 469Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeuroscience and Neuropharmacology Research

Structural and functional diversity of native brain neuronal nicotinic receptors

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Gotti, Cecilia, Clementi, Francesco, Fornari, Alice, Gaimarri, Annalisa, Guiducci, Stefania, Manfredi, Irene, Moretti, Milena, Pedrazzi, Patrizia +2 more·2009·Biochemical Pharmacology

Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharmacological and functional properties arise from the wide range of different subunit combinations making up distinctive subtypes. nAChRs are involved in many physiological functions in the central and peripheral nervous systems, and are the targets of the widely used drug of abuse nicotine. In addition to tobacco dependence, changes in their number and/or function are associated with neuropsychiatric disorders, ranging from epilepsy to dementia. Although some of the neural circuits involved in the acute and chronic effects of nicotine have been identified, much less is known about which native nAChR subtypes are involved in specific physiological functions and pathophysiological conditions. We briefly review some recent findings concerning the structure and function of native nAChRs, focusing on the subtypes identified in the mesostriatal and habenulo-interpeduncular pathways, two systems involved in nicotine reinforcement and withdrawal. We also discuss recent findings concerning the effect of chronic nicotine on the expression of native subtypes.

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Crossref · 10.1016/j.bcp.2009.05.024

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  • nAChR upregulation varies by receptor subtype, brain region, and contingency of nicotine administration.

    “Relevant to the understanding of the neuroadaptations produced by nicotine is the fact that nAChR upregulation differs among receptor subtypes, varies among brain regions for the same subtype, and even depends on the contingency of nicotine administration [9, 90, 93].”

    From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [9]

  • Nicotine generally acts in the central nervous system through nicotinic acetylcholine receptors.

    “Nicotine generally exerts its effects in the central nervous system (CNS) via an interaction at nicotinic acetylcholine receptors (nAChRs) (Albuquerque et al., 2009;Gotti et al., 2009).”

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Authors
Gotti, C., Clementi, F., Fornari, A., Gaimarri, A., Guiducci, S., Manfredi, I., Moretti, M., Pedrazzi, P., Pucci, L., & Zoli, M.
Affiliations
  • University of Milan (IT)
  • University of Modena and Reggio Emilia (IT)
Corresponding author
Gotti, Cecilia
Venue
Biochemical Pharmacology
Publisher
Elsevier BV
Published
2009-10
Volume
78
Issue
7
Pages
703-711
ISSN
0006-2952 (ISSN-L)
OpenAlex
W2040106038
Cited by
469
References
127
Citations by year
2026: 7 · 2025: 14 · 2024: 19 · 2023: 17 · 2022: 21 · 2021: 29 · 2020: 31 · 2019: 20 · 2018: 23 · 2017: 24 · 2016: 30 · 2015: 41 · 2014: 46 · 2013: 47 · 2012: 28
FWCI
2.63
Type
journal article
Language
en
Open access
Locations
  • Biochemical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal nicotinic acetylcholine receptors, nAChR subtypes, ligand-gated ion channels, nicotine, nicotine reinforcement, nicotine withdrawal, mesostriatal pathway, neuropsychiatric disorders, epilepsy, dementia, tobacco dependence
MeSH terms
Animals, Brain, Humans, Neural Pathways, Neurons, Nicotine, Protein Conformation, Receptors, Nicotinic, Tobacco Use Disorder, Nicotinic Agonists, Protein Subunits, Protein Multimerization

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