The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Dopamine gating of forebrain neural ensembles
Abstract
Dopamine may exert different actions depending on a number of factors. A common view is that D 1 receptors may be responsible for excitatory actions whereas D 2 receptors are involved in inhibitory actions. However, this position cannot be reconciled with several findings indicating otherwise. The role of dopamine on forebrain neural ensembles may be better understood in the light of functional states of the system. Pyramidal cortical neurons and striatal medium spiny neurons alternate between two membrane potential states (‘up’ and ‘down’) that could shape dopamine actions. It is proposed that D 1 receptors can act as state‐stabilizers by sustaining up states and thereby facilitating plasticity mechanisms by providing postsynaptic depolarization and increasing NMDA function. In this way, dopamine can sustain activity in depolarized units. This action is accompanied by a decrease in cell firing (perhaps mediated by D 2 receptors), which renders the cells responsive only to strong stimuli. The result would be a net increase in signal‐to‐noise ratio in a selected assembly of neurons.
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Cites
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Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
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Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
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The mysterious motivational functions of mesolimbic dopamine
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Metadata
- Authors
- O'Donnell, P.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-01-31
- Volume
- 17
- Issue
- 3
- Pages
- 429-435
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2139882380
- Cited by
- 256
- References
- 96
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
