Anticipatory cortical responses during the expectancy of a predictable painful stimulation. A high-resolution electroencephalography study
Abstract
In the present study, high-resolution electroencephalography techniques modelled the spatiotemporal pattern of human anticipatory cortical responses preceding expected galvanic painful stimuli (non-painful stimuli as a control). Do these responses reflect the activation of associative other than somatosensory systems? Anticipatory processes were probed by alpha oscillations (6-12 Hz) for the evaluation of thalamocortical channels and by negative event-related potentials for the evaluation of cortical excitability. Compared with the control condition, a progressive reduction of the alpha power was recognized over the primary somatosensory cortex from 2 s before the painful stimulation. In contrast, the anticipatory event-related potentials were negligible during the expectancy period. The results on the alpha power suggest that the expectancy of the painful stimulation specifically facilitated the somatosensory thalamocortical channel. Remarkably, the associative frontal-parietal areas were not involved, possibly due to the predictable and repetitive features of the painful stimulus. The present results also suggest that negative event-related potentials are modest preceding warned stimuli (even if painful) with a simple information content.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alpha suppression appears sensitive to cues indicating threat, with stronger suppression while negative versus positive pictures or painful versus nonpainful stimuli were anticipated.
“Alpha suppression presumably reflects preparatory activity in the visual cortex (Van Dijk, Schoffelen, Oostenveld, & Jensen, 2008) and appears sensitive to cues indicating threat, with stronger suppression while negative versus positive pictures (Onoda et al., 2007) or painful versus nonpainful stimuli (Babiloni et al., 2003) were anticipated.”
From Uncertainty increases neural indices of attention in obsessive-compulsive disorder (2017) · cites this paper as Babiloni et al., 2003
Cites
Event-related EEG/MEG synchronization and desynchronization: basic principles
Pfurtscheller, G., & Lopes da Silva, F. H. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00141-8 · Cited by 7,328 · see citing works
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,542 · see citing works
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629 · see citing works
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171 · see citing works
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151 · see citing works
The cortical representation of pain
Treede, R.-D., Kenshalo, D. R., Gracely, R. H., & Jones, A. K. P. (1999) · Pain · doi:10.1016/s0304-3959(98)00184-5 · Cited by 1,077 · see citing works
Memory processes, brain oscillations and EEG synchronization
Klimesch, W. (1996) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(96)00057-8 · Cited by 923 · see citing works
Neocortical Dynamics and Human EEG Rhythms
Collura, T. F. (1996) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199603000-00010 · Cited by 896 · see citing works
Induced alpha band power changes in the human EEG and attention
Klimesch, W., Doppelmayr, M. M., Russegger, H., Pachinger, T., & Schwaiger, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00122-0 · Cited by 895 · see citing works
Pain perception: Is there a role for primary somatosensory cortex?
Bushnell, M. C., Duncan, G. H., Hofbauer, R. K., Ha, B., Chen, J.-I., & Carrier, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7705 · Cited by 736 · see citing works
EEG-alpha rhythms and memory processes
Klimesch, W. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00773-3 · Cited by 733 · see citing works
BRUNIA, C. H. M., & Boxtel, G. J. M. V. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00179-9 · Cited by 722 · see citing works
Cortical Representation of the Sensory Dimension of Pain
Hofbauer, R. K., Rainville, P., Duncan, G. H., & Bushnell, M. C. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.402 · Cited by 611 · see citing works
The physiological basis of attentional modulation in extrastriate visual areas
Chawla, D., Rees, G. E., & Friston, K. J. (1999) · Nature Neuroscience · doi:10.1038/10230 · Cited by 535 · see citing works
Does anticipation of pain affect cortical nociceptive systems?
Porro, C. A., Baraldi, P., Pagnoni, G., Serafini, M., Facchin, P., Maieron, M., & Nichelli, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03206.2002 · Cited by 469 · see citing works
Pfurtscheller, G., Neuper, C., Andrew, C. M., & Edlinger, G. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00760-5 · Cited by 457 · see citing works
Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety
Simpson, J. R., Drevets, W. C., Snyder, A. Z., Gusnard, D. A., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.688 · Cited by 438 · see citing works
Pain-related cerebral activation is altered by a distracting cognitive task
Petrović, P., Petersson, K. M., Ghatan, P. H., Stone‐Elander, S., & Ingvar, M. (2000) · Pain · doi:10.1016/s0304-3959(99)00232-8 · Cited by 419 · see citing works
Neurophysiological evaluation of pain
Bromm, B., & Lorenz, J. (1998) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/s0013-4694(98)00075-3 · Cited by 410 · see citing works
Neurophysiology and Functional Neuroanatomy of Pain Perception
Schnitzler, A., & Ploner, M. (2000) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200011000-00005 · Cited by 349 · see citing works
Imaging cognitive modulation of pain processing
Petrovic, P., & Ingvar, M. (2002) · Pain · doi:10.1016/s0304-3959(01)00467-5 · Cited by 318 · see citing works
Blood flow changes in human somatosensory cortex during anticipated stimulation
Drevets, W. C., Burton, H., Videen, T. O., Snyder, A. Z., Simpson, J. R., & Raichle, M. E. (1995) · Nature · doi:10.1038/373249a0 · Cited by 310 · see citing works
Neural aspects of anticipatory behavior
BRUNIA, C. H. M. (1999) · Acta Psychologica · doi:10.1016/s0001-6918(99)00006-2 · Cited by 296 · see citing works
Ingvar, M. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0483 · Cited by 274 · see citing works
Temporal and Intensity Coding of Pain in Human Cortex
Porro, C. A., Cettolo, V., Francescato, M. P., & Baraldi, P. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3312 · Cited by 253 · see citing works
Hsieh, J.-C., Stone-Elander, S., & Ingvar, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00060-9 · Cited by 238 · see citing works
Babiloni, F., Babiloni, C., Carducci, F., Fattorini, L., Onorati, P., & Urbano, A. (1996) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(96)00284-2 · Cited by 231 · see citing works
Self-citationThe intracutaneous stimulus: a new pain model for algesimetric studies.
Bromm, B., & Meier, W. (1984) · PubMed · Cited by 220 · see citing works
The medial pain system, cingulate cortex, and parallel processing of nociceptive information
Vogt, B. A., & Sikes, R. W. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62141-x · Cited by 216 · see citing works
Tickling Expectations: Neural Processing in Anticipation of a Sensory Stimulus
Carlsson, K., Petrović, P., Skare, S. T., Petersson, K. M., & Ingvar, M. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562318 · Cited by 192 · see citing works
Two Modulatory Effects of Attention That Mediate Object Categorization in Human Cortex
Rees, G. E., Frackowiak, R. S. J., & Frith, C. (1997) · Science · doi:10.1126/science.275.5301.835 · Cited by 159 · see citing works
Alpha Frequency, Reaction Time, and the Speed of Processing Information
Klimesch, W., Doppelmayr, M. M., Schimke, H., & Pachinger, T. (1996) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199611000-00006 · Cited by 156 · see citing works
New perspectives in EEG/MEG brain mapping and PET/fMRI neuroimaging of human pain
Chen, A. C. N. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00163-5 · Cited by 138 · see citing works
Self-citationBabiloni, F., Febo Cincotti, A., Carducci, F., Rossini, P. M., & Babiloni, C. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00494-1 · Cited by 136 · see citing works
Self-citationAnticipatory attention: an event-related desynchronization approach
BASTIAANSEN, M. C. M., & BRUNIA, C. H. M. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00181-7 · Cited by 129 · see citing works
Stimulus-preceding negativity induced by fear: a manifestation of affective anticipation
Böcker, K. B. E., Baas, J. M. P., Kenemans, J. L., & Verbaten, M. N. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00180-5 · Cited by 128 · see citing works
Babiloni, F., Babiloni, C., Fattorini, L., Carducci, F., Onorati, P., & Urbano, A. (1995) · Brain Topography · doi:10.1007/bf01187668 · Cited by 115 · see citing works
Self-citationBASTIAANSEN, M. C. M., Böcker, K. B. E., BRUNIA, C. H. M., de Munck, J. C., & Spekreijse, H. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00537-x · Cited by 109 · see citing works
Brain Activation Induced by the Perceptual Maze Test: A PET Study of Cognitive Performance
Ghatan, P. H., Hsieh, J. P.-T., Meurling, A. W., Wredling, R., Eriksson, L. I., Stone‐Elander, S., Levander, S. E., & Ingvar, M. (1995) · NeuroImage · doi:10.1006/nimg.1995.1014 · Cited by 90 · see citing works
Babiloni, C., Babiloni, F., Carducci, F., Febo Cincotti, A., Rosciarelli, F., Arendt‐Nielsen, L., Chen, A. C. N., & Rossini, P. M. (2001) · Human Brain Mapping · doi:10.1002/hbm.10013 · Cited by 89 · see citing works
Self-citationPain-related somatosensory evoked magnetic fields
Kitamura, Y., Kakigi, R., Hoshiyama, M., Koyama, S., Shimojo, M., & Watanabe, S. (1995) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(95)00139-5 · Cited by 88 · see citing works
Human brain measures of clinical pain: a review II. Tomographie imagings
Chen, A. C. N. (1993) · Pain · doi:10.1016/0304-3959(93)90201-y · Cited by 88 · see citing works
Self-citationFilipović, S. R., Jahanshahi, M., & Rothwell, J. C. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00558-2 · Cited by 85 · see citing works
Improved realistic Laplacian estimate of highly-sampled EEG potentials by regularization techniques
Babiloni, F., Carducci, F., Babiloni, C., & Urbano, A. (1998) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/s0013-4694(97)00124-7 · Cited by 79 · see citing works
Self-citationMotor and non-motor components of the contingent negative variation
Boxtel, G. J. M. V., & BRUNIA, C. H. M. (1994) · International Journal of Psychophysiology · doi:10.1016/0167-8760(94)90069-8 · Cited by 73 · see citing works
Brain and Behavior: Past, Present and Future
Boxtel, G. J. M. V., & Böcker, K. B. E. (1997) · Research portal (Tilburg University) · Cited by 72 · see citing works
Effect of positive and negative emotion on stimulus‐preceding negativity prior to feedback stimuli
Kotani, Y., Hiraku, S., Suda, K., & Aihara, Y. (2001) · Psychophysiology · doi:10.1111/1469-8986.3860873 · Cited by 64 · see citing works
Human brain measures of clinical pain: a review I. Topographic mappings
Chen, A. C. N. (1993) · Pain · doi:10.1016/0304-3959(93)90200-9 · Cited by 63 · see citing works
Self-citationBromm, B., Meier, W., & Scharein, E. (1989) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(89)90119-3 · Cited by 41 · see citing works
ERD and ERS in voluntary movement of different limbs
Pfurtscheller, G., Schmid‐Zalaudek, K., & Neuper, C. (1999) · Cited by 41 · see citing works
Kotani, Y., & Aihara, Y. (1999) · Biological Psychology · doi:10.1016/s0301-0511(98)00047-7 · Cited by 39 · see citing works
A Regression Analysis Study of the Primary Somatosensory Cortex during Pain
Petrović, P. (2002) · NeuroImage · doi:10.1006/nimg.2002.1069 · Cited by 38 · see citing works
ERD as an index of anticipatory attention? Effects of stimulus degradation
Bastiaansen, M. C. M., Böcker, K. B. E., & Brunia, C. H. M. (2002) · Psychophysiology · doi:10.1111/1469-8986.3910016 · Cited by 36 · see citing works
Laser-evoked potentials in human pain
Chen, A. C. N., Arendt‐Nielsen, L., & Plaghki, L. (1998) · Pain Forum · doi:10.1016/s1082-3174(98)70002-9 · Cited by 31 · see citing works
Self-citationEvent-related potential correlates of non-motor anticipation
Chwilla, D. J., & BRUNIA, C. H. M. (1991) · Biological Psychology · doi:10.1016/0301-0511(91)90005-2 · Cited by 28 · see citing works
Task-Specific Expectation Is Revealed in Scalp-Recorded Slow Potentials
Mnatsakanian, E. V., & Tarkka, I. M. (2002) · Brain Topography · doi:10.1023/a:1021416406992 · Cited by 21 · see citing works
[Quality control in computed tomography].
Rockstroh, G., Lieberenz, S., & Straubel, U. (1989) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Imaging the Social Brain by Simultaneous Hyperscanning during Subject Interaction
Astolfi, L., Toppi, J., De Vico Fallani, F., Vecchiato, G., Cincotti, F., Wilke, C., Yuan, H., Mattia, D., Salinari, S., He, B., et al. (2011) · IEEE Intelligent Systems · doi:10.1109/mis.2011.61 · Cited by 110 · see citing works
Self-citationOnoda, K., Okamoto, Y., Shishida, K., Hashizume, A., Ueda, K., Yamashita, H., & Yamawaki, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.026 · Cited by 61 · see citing works
Uncertainty increases neural indices of attention in obsessive-compulsive disorder
Dieterich, R., Endrass, T., & Kathmann, N. (2017) · Depression and Anxiety · doi:10.1002/da.22655 · Cited by 22 · see citing works
- Authors
- Babiloni, C., Brancucci, A., Babiloni, F., Capotosto, P., Carducci, F., Cincotti, F., Arendt‐Nielsen, L., Chen, A. C. N., & Rossini, P. M.
- Affiliations
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Sapienza University of Rome (IT)
- Aalborg University (DK)
- Università Campus Bio-Medico (IT)
- ORCID
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-09
- Volume
- 18
- Issue
- 6
- Pages
- 1692-1700
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2067329241
- Cited by
- 103
- References
- 58
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 10
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- expectancy, skin conductance, alpha oscillations, primary somatosensory cortex, cortical excitability, pain anticipation
- MeSH terms
- Adult, Analysis of Variance, Attention, Attitude, Brain Mapping, Electrodes, Electroencephalography, Evoked Potentials, Somatosensory, Humans, Numerical Analysis, Computer-Assisted, Pain, Photic Stimulation, Physical Stimulation, Somatosensory Cortex, Time Factors, Artifacts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
