Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study
Abstract
We used positron emission tomography (PET) to monitor the regional cerebral blood flow (rCBF) as an index of brain activity in regions proposed to participate in affective-motivational and cognitive-evaluative dimensions of pain during anticipation of a noxious stimulation. Specifically we were interested in the anterior cingulate cortex (ACC), the ventromedial prefrontal cortex (VMPFC) and the periaqueductal grey (PAG). Anticipating an unpredictable and unlearned pain stimulus activated the right ACC, the VMPFC and the PAG while anticipating a learned pain-stimulus resulted in a decreased activity in the ACC and the VMPFC. These patterns are compatible with two facets of affect-laden cognitive coping: alertness and attention-distraction. The right-preponderant expression of the changes in the ACC supports the hypothesis of a preferential role of the non-dominant hemisphere in negative emotional processing. The data demonstrate an anticipatory coping mechanism and illustrate a neurophysiological process underlying the modulation of attention to pain.
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In Hsieh et al., subjects who had participated in multiple practice sessions in which a pain stimulus was delivered showed decreased activity in the caudal ACC and subgenual ACC while waiting to receive the stimulus, whereas those who had not had this experience showed increased activity in the same areas.
“Subjects who had participated in multiple practice sessions in which a pain stimulus was delivered showed decreased activity in the caudal ACC and subgenual ACC while waiting to receive the stimulus, whereas those who had not had this experience showed increased activity in the same areas.”
From Psychological aspects of persistent pain: Current state of the science (2004) · cites this paper as [36]
Hsieh et al. have reported that brain activation during the anticipation of pain might depend on experience.
“have reported that brain activation during the anticipation of pain might depend on experience.”
From Psychological aspects of persistent pain: Current state of the science (2004) · cites this paper as [36]
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- Authors
- Hsieh, J.-C., Stone-Elander, S., & Ingvar, M.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Hsieh, Jen-Chuen
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 262
- Issue
- 1
- Pages
- 61-64
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2123574770
- Cited by
- 238
- References
- 4
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 15 · 2015: 10 · 2014: 9 · 2013: 13 · 2012: 6
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- pain anticipation, anterior cingulate cortex, ventromedial prefrontal cortex, periaqueductal gray, regional cerebral blood flow, attentional modulation of pain, hemispheric lateralization, non-dominant hemisphere, pain coping
- MeSH terms
- Adaptation, Psychological, Adult, Cerebral Cortex, Gyrus Cinguli, Humans, Middle Aged, Pain, Pain Measurement, Tomography, Emission-Computed
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