The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease)
Open accessAbstract
Previous group studies using positron emission tomography to assess resting cerebral glucose metabolism in very early Alzheimer's disease and mild cognitive impairment have identified the posterior cingulate and adjacent cingulo-parietal cortex as the first isocortical area to develop hypometabolism. We studied the profile of resting cerebral glucose metabolism in individuals with mild cognitive impairment to assess whether more specific and stereotyped regional hypometabolism would be evident across subjects. The study found that the most consistently hypometabolic region between individual subjects was a subregion of the posterior cingulate, the retrosplenial cortex (BA 29/30). This result is discussed in the context of regional connectivity, focal lesion evidence and functional activation studies of episodic memory paradigms in both normal and Alzheimer's disease groups. We propose that the retrosplenial cortex may represent a key junction between prefrontal areas involved in implementing retrieval strategies for episodic memory and hippocampal-based mnemonic processing; we therefore interpret the retrosplenial hypometabolism as a probable contributor to the memory impairment seen in mild cognitive impairment by disconnecting these two anatomical networks.
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“while the posterior cingulate cortex undergoes early hypometabolism [15,53].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [53]
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WITHDRAWNPreprint
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(2025) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/jy3st_v7
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Metadata
- Authors
- Nestor, P. J., Fryer, T. D., Ikeda, M., & Hodges, J. R.
- Affiliations
- University of Cambridge (GB)
- Ehime University (JP)
- MRC Cognition and Brain Sciences Unit (GB)
- Corresponding author
- Nestor, P. J.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-11
- Volume
- 18
- Issue
- 9
- Pages
- 2663-2667
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1965683618
- Cited by
- 227
- References
- 42
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 13 · 2012: 5
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- retrosplenial cortex, posterior cingulate cortex, cerebral glucose hypometabolism, mild cognitive impairment, prodromal Alzheimer's disease, episodic memory, memory retrieval strategies
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Glucose, Gyrus Cinguli, Humans, Memory Disorders, Middle Aged, Tomography, Emission-Computed
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