Cited by 227Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurobiology of Language and Bilingualism

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease)

Open access

Nestor, P. J., Fryer, T. D., Ikeda, M., Hodges, J. R.·2003·European Journal of Neuroscience

DOI 10.1046/j.1460-9568.2003.02999.x

Open this paper in CoChat — free account Open PDF

Abstract

Previous group studies using positron emission tomography to assess resting cerebral glucose metabolism in very early Alzheimer's disease and mild cognitive impairment have identified the posterior cingulate and adjacent cingulo-parietal cortex as the first isocortical area to develop hypometabolism. We studied the profile of resting cerebral glucose metabolism in individuals with mild cognitive impairment to assess whether more specific and stereotyped regional hypometabolism would be evident across subjects. The study found that the most consistently hypometabolic region between individual subjects was a subregion of the posterior cingulate, the retrosplenial cortex (BA 29/30). This result is discussed in the context of regional connectivity, focal lesion evidence and functional activation studies of episodic memory paradigms in both normal and Alzheimer's disease groups. We propose that the retrosplenial cortex may represent a key junction between prefrontal areas involved in implementing retrieval strategies for episodic memory and hippocampal-based mnemonic processing; we therefore interpret the retrosplenial hypometabolism as a probable contributor to the memory impairment seen in mild cognitive impairment by disconnecting these two anatomical networks.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.1460-9568.2003.02999.x

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598
Le test de copie d'une figure complexe
Osterrieth, P. M. (1944) · Medical Entomology and Zoology · Cited by 2,336
Wechsler memory scale-revised
Reynolds, C. R., & Powel, J. (1988) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/3.4.397 · Cited by 2,123
Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review) [RETIRED]: Report of the Quality Standards Subcommittee of the American Academy of Neurology
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802
Perirhinal and parahippocampal cortices of the macaque monkey: Cortical afferents
Suzuki, W., & Amaral, D. G. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500402 · Cited by 1,149

Show all 42 references

Research works printed but not linked: 2

Baddeley A.D., 1994, The Doors and People Test: a test of visual and verbal recall and recognition.
Taniwaki T., 1996, Persistent amnesia due to posterior cerebral artery territory – a case of retrosplenial amnesia, Neurol. Med., 45, 507

Sorted by citations

Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies
Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp055 · Cited by 4,060
What does the retrosplenial cortex do?
Vann, S. D., Aggleton, J. P., & Maguire, E. A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2733 · Cited by 1,409
Semantic dementia: a unique clinicopathological syndrome
Hodges, J. R., & Patterson, K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70266-1 · Cited by 772
Self-citation
Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study
Chételat, G., Landeau, B., Eustache, F., Mézenge, F., Viader, F., de la Sayette, V., Desgranges, B., & Baron, J.-C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.05.015 · Cited by 526
Posterior cingulate cortex: adapting behavior to a changing world
Pearson, J. M., Heilbronner, S. R., Barack, D. L., Hayden, B. Y., & Platt, M. L. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.02.002 · Cited by 504
Advances in the early detection of Alzheimer's disease
Nestor, P. J., Scheltens, P., & Hodges, J. R. (2004) · Nature Medicine · doi:10.1038/nrn1433 · Cited by 480
Self-citation
Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
Kalpouzos, G., Chételat, G., Baron, J.-C., Landeau, B., Mevel, K., Godeau, C., Barré, L., Constans, J.-M., Viader, F., Eustache, F., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.019 · Cited by 392
Going beyond LTM in the MTL: A synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception
Graham, K. S., Barense, M. D., & Lee, A. C. H. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.01.001 · Cited by 404
Thalamic pathology and memory loss in early Alzheimer’s disease: moving the focus from the medial temporal lobe to Papez circuit
Aggleton, J. P., Pralus, A., Nelson, A. J. D., & Hornberger, M. (2016) · Brain · doi:10.1093/brain/aww083 · Cited by 378
Declarative memory impairments in Alzheimer's disease and semantic dementia
Nestor, P. J., Fryer, T. D., & Hodges, J. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.008 · Cited by 370
Self-citation
Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease
Villain, N., Desgranges, B., Viader, F., de la Sayette, V., Mezenge, F., Landeau, B., Baron, J.-C., Eustache, F., & Chetelat, G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1392-08.2008 · Cited by 366
Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
Chételat, G., Desgranges, B., Landeau, B., Mézenge, F., Poline, J.-B., Sayette, V. D. L., Viader, F., Eustache, F., & Baron, J. (2007) · Brain · doi:10.1093/brain/awm288 · Cited by 349
Parietal cortex matters in Alzheimer's disease: An overview of structural, functional and metabolic findings
Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.009 · Cited by 293
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease
Li, Y., Rinne, J. O., Mosconi, L., Pirraglia, E., Rusinek, H., DeSanti, S., Kemppainen, N., Någren, K., Kim, B.-C., Tsui, W., et al. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0833-y · Cited by 278
Retrosplenial cortex and its role in spatial cognition
Mitchell, A. S., Czajkowski, R., Zhang, N., Jeffery, K. J., & Nelson, A. J. D. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818757098 · Cited by 290
The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT
Hirao, K., Ohnishi, T., Hirata, Y., Yamashita, F., Mori, T., Moriguchi, Y., Matsuda, H., Nemoto, K., Imabayashi, E., Yamada, M., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.066 · Cited by 265
Egocentric and allocentric spatial reference frames in aging: A systematic review
Colombo, D., Serino, S., Tuena, C., Pedroli, E., Dakanalis, A., Cipresso, P., & Riva, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.012 · Cited by 284
NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.006 · Cited by 249
In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)
Sartory, G., Cwik, J. C., Knuppertz, H., Schürholt, B., Lebens, M., Seitz, R. J., & Schulze, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058150 · Cited by 252
The human perirhinal cortex and semantic memory
Davies, R. R., Graham, K. S., Xuereb, J. H., Williams, G. B., & Hodges, J. R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03710.x · Cited by 238
Self-citation
Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer’s disease
Villain, N., Fouquet, M., Baron, J.-C., Mezenge, F., Landeau, B., de La Sayette, V., Viader, F., Eustache, F., Desgranges, B., & Chetelat, G. (2010) · Brain · doi:10.1093/brain/awq203 · Cited by 237
Alzheimer's centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects
Hodges, J. R. (2006) · Brain · doi:10.1093/brain/awl275 · Cited by 227
Self-citation
Episodic memory in frontotemporal dementia: a critical review
Hornberger, M., & Piguet, O. (2012) · Brain · doi:10.1093/brain/aws011 · Cited by 210
Anosognosia in Alzheimer’s disease – The petrified self
Mograbi, D. C., Brown, R. G., & Morris, R. G. (2009) · Consciousness and Cognition · doi:10.1016/j.concog.2009.07.005 · Cited by 215
Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility
Mortamais, M., Ash, J. A., Harrison, J., Kaye, J. A., Kramer, J. H., RANDOLPH, C. C., Pose, C., Albala, B., Ropacki, M. T., Ritchie, C. W., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.2365 · Cited by 212
Lost in spatial translation – A novel tool to objectively assess spatial disorientation in Alzheimer's disease and frontotemporal dementia
Tu, S., Wong, S., Hodges, J. R., Irish, M., Piguet, O., & Hornberger, M. (2015) · Cortex · doi:10.1016/j.cortex.2015.03.016 · Cited by 180
Self-citation
Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease
Choo, I. H., Lee, D. Y., Oh, J. S., Lee, J. S., Lee, D. S., Song, I. C., Youn, J. C., Kim, S. G., Kim, K. W., Jhoo, J. H., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.06.015 · Cited by 211
Episodic and semantic memory in mild cognitive impairment
Dudas, R. B., Clague, F., Thompson, S., Graham, K. S., & Hodges, J. R. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.12.005 · Cited by 190
Self-citation
Different functions in the cingulate cortex, a meta-analytic connectivity modeling study
Torta, D. M. E., & Cauda, F. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.066 · Cited by 173
FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment
Chételat, G., Eustache, F., Viader, F., Sayette, V. D. L., Pèlerin, A., Mézenge, F., Hannequin, D., Dupuy, B., Baron, J., & Desgranges, B. (2005) · Neurocase · doi:10.1080/13554790490896938 · Cited by 164
Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study
Desgranges, B., Matuszewski, V., Piolino, P., Chételat, G., Mézenge, F., Landeau, B., Sayette, V. D. L., Belliard, S., & Eustache, F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.006 · Cited by 164
Spatial Memory Formation and Memory-Enhancing Effect of Glucose Involves Activation of the Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway
Dash, P. K., Orsi, S. A., & Moore, A. N. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0671-06.2006 · Cited by 141
The Hub-and-Spoke Hypothesis of Semantic Memory
Patterson, K. E., & Ralph, M. A. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-407794-2.00061-4 · Cited by 160
Uncovering the Neural Bases of Cognitive and Affective Empathy Deficits in Alzheimer’s Disease and the Behavioral-Variant of Frontotemporal Dementia
Dermody, N., Wong, S., Ahmed, R. M., Piguet, O., Hodges, J. R., & Irish, M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160175 · Cited by 159
Self-citation
Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease
Fouquet, M., Desgranges, B., Landeau, B., Duchesnay, É., Mézenge, F., Sayette, V. D. L., Viader, F., Baron, J., Eustache, F., & Chételat, G. (2009) · Brain · doi:10.1093/brain/awp132 · Cited by 148
Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease
Hunt, A., Schönknecht, P., Henze, M., Seidl, U., Haberkorn, U., & Schröder, J. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2006.12.003 · Cited by 146
Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment
Hämäläinen, A., Tervo, S., Grau-Olivares, M., Niskanen, E. I., Pennanen, C., Huuskonen, J., Kivipelto, M., Hänninen, T., Tapiola, M., Vanhanen, M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.016 · Cited by 142
Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing
Bak, T. H., Yancopoulou, D., Nestor, P. J., Xuereb, J. H., Spillantini, M. G., Friedemann Pulvermüller, A., & Hodges, J. R. (2005) · Brain · doi:10.1093/brain/awh701 · Cited by 135
Self-citation
Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain
Carrero, I., Gonzalo, M. R., Martin, B., Sanz-Anquela, J. M., Arévalo-Serrano, J., & Gonzalo-Ruiz, A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.004 · Cited by 132
Neural Basis of Motivational and Cognitive Control
Mars, R., Sallet, J., Mfs., R., & Yeung, N. (2011) · The MIT Press eBooks · doi:10.7551/mitpress/9780262016438.001.0001 · Cited by 128
An integrative memory model of recollection and familiarity to understand memory deficits
Bastin, C., Besson, G., Simon, J., Delhaye, E., Geurten, M., Willems, S. J., & Salmon, É. (2019) · Behavioral and Brain Sciences · doi:10.1017/s0140525x19000621 · Cited by 137
Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal
Ries, M. L., Jabbar, B. M., Schmitz, T. W., Trivedi, M. A., Gleason, C. E., Carlsson, C. M., Rowley, H. A., Asthana, S., & Johnson, S. C. (2007) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617707070488 · Cited by 121
Neural Correlates of Spatial Navigation Changes in Mild Cognitive Impairment and Alzheimer’s Disease
Vlček, K., & Laczó, J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00089 · Cited by 118
EPS Mid-Career Award 2006: Understanding anterograde amnesia: Disconnections and hidden lesions
Aggleton, J. P. (2008) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470210802215335 · Cited by 113
Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry
Davies, R., Scahill, V. L., Graham, A., Williams, G. B., Graham, K. S., & Hodges, J. R. (2009) · Neuroradiology · doi:10.1007/s00234-009-0521-z · Cited by 109
Self-citation
Diffusion tensor imaging in Alzheimer's disease: insights into the limbic-diencephalic network and methodological considerations
Acosta‐Cabronero, J., & Nestor, P. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00266 · Cited by 109
Self-citation
Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis
Grön, G., Brandenburg, I., Wunderlich, A. P., & Riepe, M. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.005 · Cited by 105
Task-dependent posterior cingulate activation in mild cognitive impairment
Ries, M. L., Schmitz, T. W., Kawahara, T. N., Torgerson, B. M., Trivedi, M. A., & Johnson, S. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.030 · Cited by 105
The midlife cognitive profiles of adults at high risk of late‐onset Alzheimer's disease: The PREVENT study
Ritchie, K. A., Carrière, I., Su, L., O'Brien, J. T., Lovestone, S., Wells, K., & Ritchie, C. W. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.02.008 · Cited by 108
Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project
Ritchie, K. A., Ropacki, M. T., Albala, B., Harrison, J., Kaye, J. A., Kramer, J. H., RANDOLPH, C. C., & Ritchie, C. W. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.07.154 · Cited by 111
Alzheimer's disease diagnosis on structural MR images using circular harmonic functions descriptors on hippocampus and posterior cingulate cortex
Ahmed, O. B., Mizotin, M. M., Benois‐Pineau, J., Michèle Allard, A., Catheline, G., & Amar, C. B. (2015) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2015.04.007 · Cited by 97
Where am I and how will I get there from here? A role for posterior parietal cortex in the integration of spatial information and route planning
Calton, J. L., & Taube, J. S. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.09.015 · Cited by 98
Disruption of limbic white matter pathways in mild cognitive impairment and Alzheimer's disease: A DTI/FDG‐PET Study
Bozoki, A., Korolev, I. O., Davis, N. C., Hoisington, L. A., & Berger, K. L. (2011) · Human Brain Mapping · doi:10.1002/hbm.21320 · Cited by 91
Lost and Found: Bespoke Memory Testing for Alzheimer's Disease and Semantic Dementia
Pengas, G., Patterson, K. E., Arnold, R. J., Bird, C. M., Burgess, N., & Nestor, P. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100654 · Cited by 94
Self-citation
Assessing the mechanism of response in the retrosplenial cortex of good and poor navigators
Auger, S. D., & Maguire, E. A. (2013) · Cortex · doi:10.1016/j.cortex.2013.08.002 · Cited by 98
Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe?
Bruner, E., & Jacobs, H. I. L. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122299 · Cited by 87
Episodic future thinking is impaired in the behavioural variant of frontotemporal dementia
Irish, M., Hodges, J. R., & Piguet, O. (2013) · Cortex · doi:10.1016/j.cortex.2013.03.002 · Cited by 95
Self-citation
Looking beyond the hippocampus: old and new neurological targets for understanding memory disorders
Aggleton, J. P. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0565 · Cited by 96
Hippocampal lesions halve immediate–early gene protein counts in retrosplenial cortex: distal dysfunctions in a spatial memory system
Albasser, M. M., Poirier, G. L., Warburton, E. C., & Aggleton, J. P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05753.x · Cited by 84
Understanding retrosplenial amnesia: Insights from animal studies
Aggleton, J. P. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.09.030 · Cited by 85
Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease
Dillen, K. N. H., Jacobs, H. I. L., Kukolja, J., von Reutern, B., Richter, N., Onur, Ö. A., Dronse, J., Langen, K.-J., & Fink, G. R. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.010 · Cited by 82
Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.
Robinson, S., Keene, C. S., Iaccarino, H. F., Duan, D., & Bucci, D. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0024262 · Cited by 84
Anterior thalamic lesions stop synaptic plasticity in retrosplenial cortex slices: expanding the pathology of diencephalic amnesia
Garden, D. L. F., Massey, P. V., Caruana, D. A., Johnson, B., Warburton, E. C., Aggleton, J. P., & Bashir, Z. I. (2009) · Brain · doi:10.1093/brain/awp090 · Cited by 76
Altered brain high-energy phosphate metabolism in mild Alzheimer's disease: A 3-dimensional 31P MR spectroscopic imaging study
Rijpma, A., van der Graaf, M., Meulenbroek, O., Rikkert, M. G. M. O., & Heerschap, A. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.01.031 · Cited by 76
Lost and Forgotten? Orientation Versus Memory in Alzheimer's Disease and Frontotemporal Dementia
Yew, B., Alladi, S., Mekala, S., Hodges, J. R., & Hornberger, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120769 · Cited by 74
Self-citation
Atrophy in Alzheimer's disease and semantic dementia: an ALE meta-analysis of voxel-based morphometry studies
Chapleau, M., Aldebert, J., Montembeault, M., & Brambati, S. M. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160382 · Cited by 73
Neuronal and Astrocytic Metabolism in a Transgenic Rat Model of Alzheimer's Disease
Nilsen, L. H., Witter, M. P., & Sonnewald, U. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.37 · Cited by 73
Egocentric versus allocentric spatial memory in behavioral variant frontotemporal dementia and Alzheimer's disease
Tu, S., Spiers, H. J., Hodges, J. R., Piguet, O., & Hornberger, M. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160592 · Cited by 70
Self-citation
Longitudinal Grey and White Matter Changes in Frontotemporal Dementia and Alzheimer’s Disease
Frings, L., Yew, B., Flanagan, E., Lam, B. Y. K., Hüll, M., Huppertz, H.-J., Hodges, J. R., & Hornberger, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090814 · Cited by 69
Self-citation
Getting lost in Alzheimer’s disease: A break in the mental frame syncing
Serino, S., & Riva, G. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2012.12.031 · Cited by 74
Specific and nonspecific thalamocortical functional connectivity in normal and vegetative states
Zhou, J., Liu, X., Song, W., Yang, Y., Zhao, Z., Ling, F., Hudetz, A. G., & Li, S. (2010) · Consciousness and Cognition · doi:10.1016/j.concog.2010.08.003 · Cited by 68
Mild cognitive impairment: historical development and summary of research
Golomb, J. B., Kluger, A., & Ferris, S. H. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.4/jgolomb · Cited by 69
Neuroimaging findings in frontotemporal lobar degeneration spectrum of disorders
Agosta, F., Canu, E., Sarro, L., Comı, G., & Filippi, M. (2011) · Cortex · doi:10.1016/j.cortex.2011.04.012 · Cited by 64
Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease
Zhang, X., Sun, Y., Li, W., Liu, B., Wu, W., Zhao, H., Liu, R., Zhang, Y., Yin, Z., Yu, T., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101723 · Cited by 59
The use of PIB-PET as a dual pathological and functional biomarker in AD
Forsberg, A., Engler, H., Blomquist, G., Långström, B., & Nordberg, A. K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.006 · Cited by 59
Accelerated forgetting in subjects with memory complaints
Manes, F., Serrano, C. M., Calcagno, M. L., Cardozo, J., & Hodges, J. R. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0850-6 · Cited by 57
Self-citation
TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Alquezar, C., Schoch, K. M., Geier, E. G., Ramos, E. M., Scrivo, A., Li, K. H., Argouarch, A. R., Mlynarski, E. E., Dombroski, B., DeTure, M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg3897 · Cited by 56
The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease
Pengas, G., Williams, G. B., Acosta‐Cabronero, J., Ash, T., Hong, Y. T., Izquierdo‐Garcia, D., Fryer, T. D., Hodges, J. R., & Nestor, P. J. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00017 · Cited by 62
Self-citation
Alzheimer disease detection from structural MR images using FCM based weighted probabilistic neural network
Duraisamy, B., Shanmugam, J. V., & Annamalai, J. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9831-2 · Cited by 55
Anterior retrosplenial cortex is required for long-term object recognition memory
de Landeta, A. B., Pereyra, M., Medina, J. H., & Katche, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-60937-z · Cited by 55
Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age
Duffy, Á., Morales‐Corraliza, J., Bermudez‐Hernandez, K., Schaner, M. J., Magagna‐Poveda, A., Mathews, P. M., & Scharfman, H. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.001 · Cited by 52
Spatial memory and navigation in ageing: A systematic review of MRI and fMRI studies in healthy participants
Li, A., & King, J. A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.005 · Cited by 62
Thalamic projections to the posteromedial cortex in the macaque
Buckwalter, J. A., V, Parvizi, J., Morecraft, R. J., & Hoesen, G. W. V. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21647 · Cited by 47
Category Selectivity for Face and Scene Recognition in Human Medial Parietal Cortex
Woolnough, O., Rollo, P. S., Forseth, K. J., Kadipasaoglu, C. M., Ekstrom, A. D., & Tandon, N. (2020) · Current Biology · doi:10.1016/j.cub.2020.05.018 · Cited by 47
Executive deficits and regional brain metabolism in Alzheimer's disease
Woo, B. K. P., Harwood, D. G., Melrose, R. J., Mandelkern, M. A., Campa, O., Walston, A., & Sultzer, D. L. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2452 · Cited by 49
Identification of subgroups in amnestic mild cognitive impairment
Guedj, É., Barbeau, E. J., Didic, M., Félician, O., de Laforte, C., Ceccaldi, M. P., MUNDLER, O., & Poncet, M. (2006) · Neurology · doi:10.1212/01.wnl.0000225076.73312.d4 · Cited by 44
Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions
Rönnbäck, A., Sagelius, H., Bergstedt, K. D., Näslund, J., Westermark, G. T., Winblad, B., & Graff, C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.012 · Cited by 43
Imaging treatment effects in Alzheimer's disease
Venneri, A. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2007.02.004 · Cited by 43
Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: deafferentation and functional compensation?
Guedj, É., Barbeau, E. J., Didic, M., Félician, O., de Laforte, C., Ranjeva, J., Poncet, M., Cozzone, P. J., MUNDLER, O., & Ceccaldi, M. P. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1060-x · Cited by 43
Brain structural, functional, and cognitive correlates of recent versus remote autobiographical memories in amnestic Mild Cognitive Impairment
Tomadesso, C., Perrotin, A., Mutlu, J., Mézenge, F., Landeau, B., Egret, S., Sayette, V. D. L., Jonin, P., Eustache, F., Desgranges, B., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.05.010 · Cited by 47
The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys
Aggleton, J. P., Saunders, R. C., Wright, N. F., & Vann, S. D. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12389 · Cited by 41
The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment
Papma, J. M., Smits, M., de Groot, M., Mattace-Raso, F. U. S., van der Lugt, A., Vrooman, H. A., Niessen, W. J., Koudstaal, P. J., Swieten, J. C. V., van der Veen, F. M., et al. (2017) · European Radiology · doi:10.1007/s00330-017-4768-1 · Cited by 39
The self-reference effect in dementia: Differential involvement of cortical midline structures in Alzheimer's disease and behavioural-variant frontotemporal dementia
Wong, S., Irish, M., Leshikar, E. D., Duarte, A., Bertoux, M., Savage, G. R., Hodges, J. R., Piguet, O., & Hornberger, M. (2016) · Cortex · doi:10.1016/j.cortex.2016.09.013 · Cited by 45
Self-citation
Investigating virtual reality navigation in amnestic mild cognitive impairment using fMRI
Migo, E. M., O’Daly, O., Mitterschiffthaler, M. T., Antonova, E., Dawson, G. R., Dourish, C. T., Craig, K. J., Simmons, A., Wilcock, G. K., McCulloch, E., et al. (2015) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2015.1073218 · Cited by 41
Requirement of an Early Activation of BDNF/c-Fos Cascade in the Retrosplenial Cortex for the Persistence of a Long-Lasting Aversive Memory
Katche, C., & Medina, J. H. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv284 · Cited by 38
Functional imaging of cognition in Alzheimer's disease using positron emission tomography
Salmon, É., Lekeu, F., Bastin, C., Garraux, G., & Collette, F. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.11.022 · Cited by 38
Maternal Endotoxin Exposure Results in Abnormal Neuronal Architecture in the Newborn Rabbit
Balakrishnan, B., Dai, H., Janisse, J. J., Romero, R. J., & Kannan, S. (2013) · Developmental Neuroscience · doi:10.1159/000353156 · Cited by 37
Retrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD
Rauchs, G., Piolino, P., Bertran, F., Sayette, V. D. L., Viader, F., Eustache, F., & Desgranges, B. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00114 · Cited by 36
Retrosplenial cortical contributions to anterograde and retrograde memory in the monkey
Buckley, M. J., & Mitchell, A. S. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw054 · Cited by 37
Frontal Dysfunction Underlies Depression in Mild Cognitive Impairment: A FDG-PET Study
Lee, H. S., Choo, I. H., Lee, D. Y., Kim, J. W., Seo, E. H., Kim, S. G., Park, S. Y., Shin, J. H., Kim, K. W., & Woo, J. I. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.3.208 · Cited by 38

Authors: Nestor, P. J., Fryer, T. D., Ikeda, M., & Hodges, J. R.
Affiliations: University of Cambridge (GB)
Ehime University (JP)
MRC Cognition and Brain Sciences Unit (GB)
Corresponding author: Nestor, P. J.
ORCID: Nestor, P. J.
Fryer, T. D.
Hodges, J. R.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2003-11
Volume: 18
Issue: 9
Pages: 2663-2667
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1046/j.1460-9568.2003.02999.x
OpenAlex: W1965683618
Cited by: 227
References: 42
Citations by year: 2026: 3 · 2025: 12 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 13 · 2012: 5
FWCI: 5.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords: retrosplenial cortex, posterior cingulate cortex, cerebral glucose hypometabolism, mild cognitive impairment, prodromal Alzheimer's disease, episodic memory, memory retrieval strategies
MeSH terms: Aged, Alzheimer Disease, Cognition Disorders, Glucose, Gyrus Cinguli, Humans, Memory Disorders, Middle Aged, Tomography, Emission-Computed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks