Obesity and immune function relationships

Martí, A.; Marcos, A.; Martínez, J. A.

doi:10.1046/j.1467-789x.2001.00025.x

Cited by 418Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityImmunotoxicology and immune responses

Obesity and immune function relationships

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Martí, A., Marcos, A., Martínez, J. A.·2001·Obesity Reviews

DOI 10.1046/j.1467-789x.2001.00025.x

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Abstract

Summary: The immunological processes involved in the collaborative defence of organisms are affected by nutritional status. Thus, a positive chronic imbalance between energy intake and expenditure leads to situations of obesity, which may influence unspecific and specific immune responses mediated by humoral and cell mediated mechanisms. Furthermore, several lines of evidence have supported a link between adipose tissue and immunocompetent cells. This interaction is illustrated in obesity, where excess adiposity and impaired immune function have been described in both humans and genetically obese rodents. However, limited and often controversial information exist comparing immunity in obese and non‐obese subjects as well as about the cellular and molecular mechanisms implicated. In general terms, clinical and epidemiological data support the evidence that the incidence and severity of specific types of infectious illnesses are higher in obese persons as compared to lean individuals together with the occurrence of poor antibody responses to antigens in overweight subjects. Leptin might play a key role in linking nutritional status with T‐cell function. The complexities and heterogeneity of the host defences concerning the immune response in different nutritional circumstances affecting the energy balance require an integral study of the immunocompetent cells, their subsets and products as well as specific and unspecific inducer/regulator systems. In this context, more research is needed to clarify the clinical implications of the alterations induced by obesity on the immune function.

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To date, only a few comparative studies have described the lymphoid accumulation in WAT of obese subjects.
“To date, only a few comparative studies have described the lymphoid accumulation in WAT of obese subjects [49].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [49]

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Authors: Martí, A., Marcos, A., & Martínez, J. A.
Affiliations: Universidad de Navarra (ES)
Universidad Complutense de Madrid (ES)
ORCID: Martí, A.
Marcos, A.
Martínez, J. A.
Venue: Obesity Reviews
Publisher: Wiley
Published: 2001-05
Volume: 2
Issue: 2
Pages: 131-140
ISSN: 1467-7881 (ISSN-L)
1467-789X
DOI: 10.1046/j.1467-789x.2001.00025.x
OpenAlex: W1971606821
Cited by: 418
References: 89
Citations by year: 2026: 6 · 2025: 14 · 2024: 23 · 2023: 26 · 2022: 19 · 2021: 21 · 2020: 26 · 2019: 17 · 2018: 20 · 2017: 18 · 2016: 23 · 2015: 22 · 2014: 24 · 2013: 22 · 2012: 23
FWCI: 0.96
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2624 d)
Locations: Obesity Reviews (publishedVersion)
PubMed (publishedVersion)
Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: obesity, immune function, adipose tissue, energy balance, leptin, T cell function, humoral immunity, cell-mediated immunity, infection susceptibility, antibody response, nutritional status
MeSH terms: Adipose Tissue, Animals, Energy Metabolism, Humans, Immunity, Nutritional Physiological Phenomena, Obesity, Leptin

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