Weight-dependent changes of immune system in adipose tissue: Importance of leptin
Abstract
Ancestral lymphoid cells reside in adipose tissues, and their numbers are highly altered in obesity. Leptin, production of which is correlated to fat mass, is strongly involved in the relationships between adipose tissues and immune system. We investigated in epididymal (EPI) and inguinal (ING) fat pads to determine whether 1) lymphocyte phenotypes were correlated to the tissue weight and 2) leptin was involved in such relationships. Immunohistological analyses revealed a tight relationship between the T and NK lymphocytes of the stromal vascular fraction and adipocytes. We identified a significant negative and positive correlation between EPI weight and the percentage of NK and total T cells respectively by cytofluorometric analyses. The NK and ancestral gammadelta T cell contents were directly dependent of leptin since they increased significantly in high-fat (HF) diet mice but not in leptin-deficient (ob/ob) mice as compared to control. By contrast, the alphabeta T cell content seemed independent of leptin because their percentages increased significantly with the EPI weight whatever the type of mice (control, HF, ob/ob). The present study suggests that adipose tissues present, according to their localization, different immunological mechanisms that might be involved in the regulation of adipose cells functions and proliferations.
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A relationship between lymphocyte count and the weight of visceral and subcutaneous fat pads was also noted.
“A relationship between lymphocyte count and the weight of visceral and subcutaneous fat pads was also noted [48].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [48]
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- Authors
- Caspar-Bauguil, S., Cousin, B., André, M., Nibbelink, M., Galinier, A., Periquet, B., Casteilla, L., & Pénicaud, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Pénicaud, L.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 312
- Issue
- 12
- Pages
- 2195-2202
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W2094434774
- Cited by
- 52
- References
- 36
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue, leptin, obesity, natural killer cells, T cells, γδ T cells, alpha beta T cells, stromal vascular fraction, epididymal adipose tissue, inguinal fat, high-fat diet, ob/ob mice, adipose tissue weight
- MeSH terms
- Adipose Tissue, Animals, Epididymis, Flow Cytometry, Immunohistochemistry, Killer Cells, Natural, Lymphocytes, Male, Mice, Inbred C57BL, T-Lymphocytes, T-Lymphocyte Subsets, CD3 Complex, Mice, Knockout, Leptin, Integrin alpha2, Adiposity, Mice, Receptors, Leptin
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