The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice
Abstract
Abstract:Administration of methamphetamine (METH) to rats and nonhuman primates causes loss of terminals in the nigrostriatal dopaminergic system. The mechanism by which METH causes its neurotoxicity is not known. To evaluate further the role of oxyradicals in METH‐induced neurotoxicity, we have tested its effects in CuZn superoxide dismutase (SOD) transgenic (Tg) mice, which express the human CuZnSOD gene. In non‐Tg mice, acute METH administration causes significant decreases in levels of dopamine (DA) and 3, 4‐dihydroxyphenylacetic acid (DOPAC) in the striata and cortices of non‐Tg mice. In contrast, there were no significant decreases in cortical or striatal DA in the SOD‐Tg mice. The effects of METH on DOPAC were also attenuated in both structures of these SOD‐Tg mice. Chronic METH administration caused decreases in levels of striatal DA and DOPAC in the non‐ Tg mice, whereas the SOD‐Tg mice were not affected. These results suggest that METH‐induced dopaminergic toxicity in mice may be secondary to increased production of reactive oxygen species such as the superoxide radical.
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Citations
Cites
In vivo monoamine oxidase inhibition by d-amphetamine
Miller, H. H., Shore, P. A., & Clarke, D. E. (1980) · Biochemical Pharmacology · doi:10.1016/0006-2952(80)90429-3 · Cited by 120
Cited by
Invited Review Free radicals and the pathobiology of brain dopamine systems
Cadet, J. L., & Brannock, C. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00031-4 · Cited by 499
Self-citationCadet, J. L., Jayanthi, S., & Deng, X. (2003) · The FASEB Journal · doi:10.1096/fj.03-0073rev · Cited by 286
Self-citationIntraneuronal dopamine-quinone synthesis: a review
Sulzer, D., & Zecca, L. (1999) · Neurotoxicity Research · doi:10.1007/bf03033289 · Cited by 284
Neurotoxins: Free radical mechanisms and melatonin protection
J. Reiter, R., C. Manchester, L., & Tan, D.-X. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246236 · Cited by 179
Yamamoto, B. K., & Raudensky, J. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9121-7 · Cited by 167
Metadata
- Authors
- Cadet, J. L., Sheng, P., All, S., Rothman, R., Carlson, E., & Epstein, C.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 62
- Issue
- 1
- Pages
- 380-383
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1988949532
- Cited by
- 263
- References
- 1
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice. https://app.cochat.ai/papers/10.1046/j.1471-4159.1994.62010380.x
- The paper
- Cadet, J. L., Sheng, P., All, S., Rothman, R., Carlson, E., & Epstein, C. (1994). Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1994.62010380.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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