Cited by 284Parkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effectsRedox biology and oxidative stress

Intraneuronal dopamine-quinone synthesis: a review

Sulzer, David, Zecca, Luigi·1999·Neurotoxicity Research

Abstract

Dopamine-quinone is synthesized by oxidation of the catechol ring of dopamine. If this occurs within the neuronal cytosol, the quinone may react with cytosolic components, particularly with cysteine residues. In contrast, if quinone is produced within neuronal lysosomes it may provide the fundamental building block for neuromelanin. Since the population of neurons that die in Parkinson's disease are those that display obvious intralysosomal neuromelanin and since cytosolic dopamine-dependent oxyradical formation may underlie methamphetamine toxicity and other specific forms of neurodegeneration in dopaminergic neurons, it is important to elucidate the pathways leading to production of dopamine-quinone. Here we review pathways by which intracellular catechols may be oxidized to quinones, either enzymatically or via reduction of ferric iron or other metals. These metabolites can be adduced by cysteine, could underlie aberrant metabolism and ubiquitination pathways, may induce Lewy body formation, and mediate the synthesis of hydroxyl radical and oxyradical species. Finally, we suggest that by accumulating excess cytosolic catecholamine, neuromelanin synthesis may safely sequester quinones that would otherwise be produced in the neuronal cytosol.

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Crossref · 10.1007/bf03033289

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  • Catecholamines, such as dopamine, might be oxidised to highly reactive or toxic quinones via the reduction of ferric iron or enzymatically.

    “Cathecolamines, such as dopamine, might be oxidised to highly reactive or toxic quinones via the reduction of ferric iron or enzymatically.65–67”

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Authors
Sulzer, D., & Zecca, L.
Affiliations
  • New York State Psychiatric Institute (US)
  • Institute of Biomedical Technologies (IT)
Corresponding author
Sulzer, David
Venue
Neurotoxicity Research
Published
1999-09
Volume
1
Issue
3
Pages
181-195
ISSN
  • 1029-8428 (ISSN-L)
  • 1476-3524
OpenAlex
W1966748491
Cited by
284
References
132
Citations by year
2026: 5 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 14 · 2020: 14 · 2019: 15 · 2018: 21 · 2017: 13 · 2016: 11 · 2015: 13 · 2014: 19 · 2013: 12 · 2012: 5
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Locations
  • Neurotoxicity Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
dopamine quinone, catechol oxidation, neuromelanin, Parkinson's disease, dopaminergic neurons, methamphetamine toxicity, cysteine adducts, oxyradicals, hydroxyl radicals, Lewy bodies, ubiquitination

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