The Role of Oxidative Stress, Metabolic Compromise, and Inflammation in Neuronal Injury Produced by Amphetamine-Related Drugs of Abuse

Yamamoto, Bryan K.; Raudensky, Jamie

doi:10.1007/s11481-008-9121-7

Cited by 167Parkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

The Role of Oxidative Stress, Metabolic Compromise, and Inflammation in Neuronal Injury Produced by Amphetamine-Related Drugs of Abuse

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Yamamoto, Bryan K., Raudensky, Jamie·2008·Journal of Neuroimmune Pharmacology

DOI 10.1007/s11481-008-9121-7PMC PMC3955110

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Abstract

Methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are amphetamine derivatives with high abuse liability. These amphetamine-related drugs of abuse mediate their effects through the acute activation of both dopaminergic and serotonergic neurons. Long-term abuse of these amphetamine derivatives, however, results in damage to both dopaminergic and serotonergic terminals throughout the brain. This toxicity is mediated in part by oxidative stress, metabolic compromise, and inflammation. The overall objective of this review is to highlight experimental evidence that METH and MDMA increase oxidative stress, produce mitochondrial dysfunction, and increase inflammation that converge and culminate in the long-term toxicity to dopaminergic and serotonergic neurons.

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Long-term use of MPH induces DA neuron loss and microglia activation causing an increase in pro-inflammatory markers TNFα and IL-1β, resulting in activation of neuroinflammation and triggering a neurodegenerative process.
“Several studies have exposed that the long-term use of MPH induces the DA neuron loss and microglia activation causing an increase in pro-inflammatory markers TNFα and IL-1β, among others, resulting in the activation of neuroinflammation and triggering a neurodegenerative process [192, 193].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [193]
The “Neurotoxicity profile of METH and MDMA” section reports long-lasting dopaminergic deficits and increases in TNF-α and IL-1β for methamphetamine (METH) and MDMA, not methylphenidate (MPH). The “Mechanisms of toxicity > Inflammation” section says microglial activation may contribute to neurotoxicity, but the role of these cytokines remains uncertain. The source therefore supports parts of the proposed pathway for different drugs, not the claim that long-term MPH use causes it. (LLM, conf=0.88)
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Ryan, L. J., Martone, M. E., Linder, J. C., & Groves, P. M. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90129-3 · Cited by 21 · see citing works

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Toxicity of amphetamines: an update
Carvalho, M. C., Carmo, H., Costa, V. M., Capela, J. P., Pontes, H., Remião, F., Carvalho, F. D., & Bastos, M. D. L. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0815-5 · Cited by 433 · see citing works
Cytokines mediated inflammation and decreased neurogenesis in animal models of depression
Song, C., & Wang, H. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.020 · Cited by 289 · see citing works
Amphetamine toxicities
Yamamoto, B. K., Moszczyńska, A., & Gudelsky, G. A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05141.x · Cited by 283 · see citing works
Self-citation
The Effects of Psychostimulant Drugs on Blood Brain Barrier Function and Neuroinflammation
Kousik, S. M., Napier, T. C., & Carvey, P. M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00121 · Cited by 175 · see citing works
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works
Methamphetamine Causes Persistent Immune Dysregulation: A Cross-Species, Translational Report
Loftis, J. M., Choi, D., Hoffman, W. F., & Huckans, M. S. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9223-x · Cited by 141 · see citing works
Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress
Sajja, R. K., Rahman, S., & Cucullo, L. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616978 · Cited by 133 · see citing works
Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
Shah, A. B., Silverstein, P. S., Singh, D. P., & Kumar, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-52 · Cited by 128 · see citing works
Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders
Nicosia, N., Giovenzana, M., Misztak, P., Mingardi, J., & Musazzi, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126521 · Cited by 135 · see citing works
Multifaces of neuropeptide Y in the brain – Neuroprotection, neurogenesis and neuroinflammation
Malva, J. O., Xapelli, S., Baptista, S., Valero, J., Agasse, F., Ferreira, R., & Silva, A. P. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.09.001 · Cited by 123 · see citing works
Methamphetamine transiently increases the blood–brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9
Martins, T., Baptista, S., Gonçalves, J., Leal, E. C., Milhazes, N., Borges, F., Ribeiro, C., Quintela, O., Lendoiro, E., López‐Rivadulla, M., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.013 · Cited by 122 · see citing works
Neuroimmune Basis of Methamphetamine Toxicity
Loftis, J. M., & Janowsky, A. J. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00007-5 · Cited by 121 · see citing works
Mediators of allostasis and systemic toxicity in bipolar disorder.
Grande, I., Magalhães, P., Kunz, M., Vieta, E., & Kapczinski, F. (2012) · Physiology and Behavior · doi:10.1016/j.physbeh.2011.10.029 · Cited by 121 · see citing works
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ‘Ecstasy’), methamphetamine and d-amphetamine
Steinkellner, T., Freissmuth, M., Sitte, H. H., & Montgomery, T. (2011) · Biological Chemistry · doi:10.1515/bc.2011.016 · Cited by 106 · see citing works
Methamphetamine influences on brain and behavior: unsafe at any speed?
Marshall, J. F., & O’Dell, S. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.05.006 · Cited by 104 · see citing works
Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension
Chen, P.-I., Cao, A., Miyagawa, K., Tojais, N. F., Hennigs, J. K., Li, C. G., Sweeney, N. M., Inglis, A. S., Wang, L., Li, D., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90427 · Cited by 106 · see citing works
HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1
Shah, A. B., Kumar, S., Simon, S. D., Singh, D. P., & Kumar, A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.374 · Cited by 103 · see citing works
Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress
Tripathy, D., & Grammas, P. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-10 · Cited by 95 · see citing works
Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress
Limanaqi, F., Gambardella, S., Biagioni, F., Busceti, C., & Fornai, F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4982453 · Cited by 84 · see citing works
Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine
Canedo, T., Portugal, C. C., Socodato, R., Almeida, T. O., Terceiro, A. F., Bravo, J., Silva, A. I., Magalhães, J. D., Guerra‐Gomes, S., Oliveira, J. F., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01139-7 · Cited by 80 · see citing works
Peripheral oxidative damage in early-stage mood disorders: a nested population-based case-control study
Magalhães, P. V. D. S., Jansen, K., Pinheiro, R. T., Colpo, G. D., da Motta, L. L., Klamt, F., da Silva, R. A., & Kapczinski, F. P. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001532 · Cited by 75 · see citing works
Methamphetamine reduces expressions of tight junction proteins, rearranges F-actin cytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway
Xue, Y., He, J.-T., Zhang, K.-K., Chen, L., Wang, Q., & Xie, X. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.144 · Cited by 75 · see citing works
Mechanism of Action of Methamphetamine within the Catecholamine and Serotonin Areas of the Central Nervous System
Chiu, V. M., & Schenk, J. O. (2012) · Current Drug Abuse Reviews · doi:10.2174/1874473711205030227 · Cited by 73 · see citing works
Mechanisms of MDMA (Ecstasy)-Induced Oxidative Stress, Mitochondrial Dysfunction, and Organ Damage
Song, B., Moon, K., Upreti, V. V., Eddington, N. D., & Lee, I. J. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110791591436 · Cited by 73 · see citing works
Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review
Quintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00392-2 · Cited by 70 · see citing works
“Several studies have exposed that the long-term use of MPH induces the DA neuron loss and microglia activation causing an increase in proinflammatory markers TNFa and IL-1b, among others, resulting in the activation of neuroinflammation and triggering a neurodegenerative process [192, 193].”
Background
Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder
Pfaffenseller, B., Fries, G. R., Wollenhaupt-Aguiar, B., Colpo, G. D., Stertz, L., Panizzutti, B., Magalhães, P. V., & Kapczinski, F. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811981 · Cited by 68 · see citing works
The Role of Oxidative Stress in Methamphetamine-induced Toxicity and Sources of Variation in the Design of Animal Studies
McDonnell‐Dowling, K., & Kelly, J. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160428110329 · Cited by 63 · see citing works
Oxidative Stress and Drugs of Abuse: An Update
Cunha‐Oliveira, T., Rego, A. C., & Oliveira, C. R. (2013) · Mini-Reviews in Organic Chemistry · doi:10.2174/1570193x113106660026 · Cited by 61 · see citing works
Peripheral Ammonia as a Mediator of Methamphetamine Neurotoxicity
Halpin, L. E., & Yamamoto, B. K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2530-12.2012 · Cited by 58 · see citing works
Self-citation
Ammonia Mediates Methamphetamine-Induced Increases in Glutamate and Excitotoxicity
Halpin, L. E., Northrop, N. A., & Yamamoto, B. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.306 · Cited by 57 · see citing works
Self-citation
Mitochondrial Mutations in Subjects with Psychiatric Disorders
Sequeira, A., Rollins, B. L., Magnan, C., van Oven, M., Baldi, P., Myers, R., Barchas, J. D., Schatzberg, A. F., Watson, S. J., Akil, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127280 · Cited by 56 · see citing works
Sex-Specific Alterations of White Matter Developmental Trajectories in Infants With Prenatal Exposure to Methamphetamine and Tobacco
Chang, L., Oishi, K., Skranes, J. S., Buchthal, S. D., Cunningham, E. P., Yamakawa, R., Hayama, S., Jiang, C. S., Alicata, D., Hernandez, A., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2794 · Cited by 55 · see citing works
Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease
Morrow, B. A., Roth, R. H., Redmond, D. E., & Elsworth, J. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.046 · Cited by 53 · see citing works
The Nature of 3, 4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonergic Dysfunction: Evidence for and Against the Neurodegeneration Hypothesis
Biezonski, D. K., & Meyer, J. S. (2011) · Current Neuropharmacology · doi:10.2174/157015911795017146 · Cited by 51 · see citing works
Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: Protective effects of selenium
Barayuga, S. M., Pang, X., Andres, M. A., Panee, J., & Bellinger, F. P. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.05.009 · Cited by 51 · see citing works
Methamphetamine-induced vascular changes lead to striatal hypoxia and dopamine reduction
Kousik, S. M., Graves, S. M., Napier, T. C., Zhao, C., & Carvey, P. M. (2011) · Neuroreport · doi:10.1097/wnr.0b013e32834d0bc8 · Cited by 50 · see citing works
Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine
Chen, H., Wu, J., Zhang, J., Fujita, Y., Ishima, T., Iyo, M., & Hashimoto, K. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2619-3 · Cited by 49 · see citing works
Melatonin Protects SH-SY5Y Neuronal Cells Against Methamphetamine-Induced Endoplasmic Reticulum Stress and Apoptotic Cell Death
Wongprayoon, P., & Govitrapong, P. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9647-z · Cited by 48 · see citing works
Enzymatic–nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity
Riezzo, I., Cerretani, D., Fiore, C., Bello, S., Centini, F., D’Errico, S., Fiaschi, A. I., Giorgi, G., Neri, M., Pomara, C., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22245 · Cited by 48 · see citing works
Substance use disorders: Psychoneuroimmunological mechanisms and new targets for therapy
Loftis, J. M., & Huckans, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.011 · Cited by 47 · see citing works
RETRACTED: Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences
Motaghinejad, M., Motevalian, M., Babalouei, F., Abdollahi, M. R., Heidari, M., & Madjd, Z. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.011 · Cited by 47 · see citing works
Retracted
Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation
Huang, Y., Hsu, N.-Y., Lu, K., Lin, Y., Lin, S.-H., Lu, Y.-S., Liu, W.-T., Chen, M.-H., & Sheen, L. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112566 · Cited by 47 · see citing works
Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1α and PERK pathways
Shah, A. B., & Kumar, A. (2016) · Oncotarget · doi:10.18632/oncotarget.10025 · Cited by 45 · see citing works
Crocin Acting as a Neuroprotective Agent against Methamphetamine-induced Neurodegeneration via CREB-BDNF Signaling Pathway.
Mozaffari, S., Yasuj, S. R., Motaghinejad, M., Motevalian, M., & Kheiri, R. (2019) · PubMed Central · doi:10.22037/ijpr.2019.2393 · Cited by 44 · see citing works
The neuroprotective effect of lithium against high dose methylphenidate: Possible role of BDNF
Motaghinejad, M., Seyedjavadein, Z., Motevalian, M., & Asadi, M. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.06.010 · Cited by 43 · see citing works
Current preclinical studies on neuroinflammation and changes in blood–brain barrier integrity by MDMA and methamphetamine
O’Shea, E., Urrutia, A., Green, A. R., & Colado, M. I. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.02.015 · Cited by 42 · see citing works
Psychoactive Drugs—From Chemical Structure to Oxidative Stress Related to Dopaminergic Neurotransmission. A Review
Jîtcă, G., Ősz, B. E., Tero-Vescan, A., & Vari, C.-E. (2021) · Antioxidants · doi:10.3390/antiox10030381 · Cited by 44 · see citing works
Neuroprotective effects of various doses of topiramate against methylphenidate-induced oxidative stress and inflammation in isolated rat amygdala: the possible role of CREB/BDNF signaling pathway
Motaghinejad, M., Motevalian, M., Falak, R., Heidari, M., Sharzad, M., & Kalantari, E. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1619-1 · Cited by 49 · see citing works
Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders
Mitra, S., Banik, A., Saurabh, S., Maulik, M., & Khatri, S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0998-21.2022 · Cited by 44 · see citing works
Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy
Oeri, H. E. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120920420 · Cited by 41 · see citing works
Emerging risk factors for heart failure in younger populations: A growing public health concern
Parizad, R., Batta, A., Hatwal, J., Sadeghi, M. T., & Mohan, B. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i4.104717 · Cited by 42 · see citing works
Hyperdopaminergic tone in HIV‐1 protein treated rats and cocaine sensitization
Ferris, M. J., Frederick-Duus, D., Fadel, J. R., Mactutus, C. F., & Booze, R. M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06968.x · Cited by 40 · see citing works
RETRACTED ARTICLE: Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and CA1 Regions of Hippocampus via CREB/BDNF Pathway in Rats
Motaghinejad, M., Motevalian, M., Abdollahi, M. R., Heidari, M., & Madjd, Z. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9695-4 · Cited by 40 · see citing works
Retracted
Mood stabilizer lithium inhibits amphetamine-increased 4-hydroxynonenal-protein adducts in rat frontal cortex
Tan, H., Young, L. T., Shao, L., Che, Y., Honer, W. G., & Wang, J.-F. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001416 · Cited by 40 · see citing works
MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus
Anneken, J. H., & Gudelsky, G. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.026 · Cited by 39 · see citing works
Neuroprotective effects of various doses of topiramate against methylphenidate induced oxidative stress and inflammation in rat isolated hippocampus
Motaghinejad, M., Motevalian, M., & Shabab, B. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12538 · Cited by 38 · see citing works
DNA Damage and Repair in Pulmonary Arterial Hypertension
Sharma, S., & Aldred, M. A. (2020) · Genes · doi:10.3390/genes11101224 · Cited by 36 · see citing works
Altered energy production, lowered antioxidant potential, and inflammatory processes mediate CNS damage associated with abuse of the psychostimulants MDMA and methamphetamine
Downey, L. A., & Loftis, J. M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.032 · Cited by 36 · see citing works
Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity
Miner, N. B., Elmore, J. S., Baumann, M. H., Phillips, T. J., & Janowsky, A. J. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.09.006 · Cited by 35 · see citing works
Chemokines, cytokines and substance use disorders
Ahearn, O., Watson, M. N., & Rawls, S. M. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108511 · Cited by 34 · see citing works
Mechanisms involved in the neurotoxic and cognitive effects of developmental methamphetamine exposure
Jablonski, S. A., Williams, M. T., & Vorhees, C. V. (2016) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21130 · Cited by 33 · see citing works
Oxidative stress response in the adult rat retina and plasma after repeated administration of methamphetamine
de Melo, P. L., Zanón‐Moreno, V., Alves, C. J., Magalhães, A., Ferreira, M. A., Pinazo-Duran, M. D., & Moradas‐Ferreira, P. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.11.017 · Cited by 32 · see citing works
The effects of 3,4-methylenedioxymethamphetamine (MDMA) on nicotinic receptors: Intracellular calcium increase, calpain/caspase 3 activation, and functional upregulation
Garcia‐Ratés, S., Camarasa, J., Sánchez-García, A. I., Gandı́a, L., Escubedo, E., & Pubill, D. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.014 · Cited by 32 · see citing works
Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine
Anneken, J. H., Angoa‐Pérez, M., Sati, G. C., Crich, D., & Kuhn, D. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.033 · Cited by 32 · see citing works
The Role of Oxidative Stress in Periodontitis
Bullón, P., Giampieri, F., Bullón, B., & Battino, M. A. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70016 · Cited by 32 · see citing works
Astrocytic clasmatodendrosis in the cerebral cortex of methamphetamine abusers
Zhang, Z., Gong, Q., Feng, X., Zhang, D., & Quan, L. (2017) · Forensic Sciences Research · doi:10.1080/20961790.2017.1280890 · Cited by 31 · see citing works
Memory and brain-derived neurotrophic factor after subchronic or chronic amphetamine treatment in an animal model of mania
Fries, G. R., Valvassori, S. S., Bock, H., Stertz, L., Magalhães, P. V. D. S., Mariot, E., Varela, R. B., Kauer‐Sant’Anna, M., Quevedo, J., Kapczinski, F. P., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.05.006 · Cited by 30 · see citing works
Upstream Pathways Controlling Mitochondrial Function in Major Psychosis
Machado, A. K., Pan, A. Y., da Silva, T. M., Duong, A., & Andreazza, A. C. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716648297 · Cited by 29 · see citing works
Oxidative stress and the antipsychotic-induced vacuous chewing movement model of tardive dyskinesia: evidence for antioxidant-based prevention strategies
Lister, J., Nóbrega, J. N., Fletcher, P. J., & Remington, G. J. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3582-6 · Cited by 28 · see citing works
MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain
Perrine, S. A., Ghoddoussi, F., Michaels, M. S., Hyde, E. M., Kuhn, D. M., & Galloway, M. P. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.08.005 · Cited by 27 · see citing works
Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice
Pereira, F. C., Cunha‐Oliveira, T., Viana, S., Travassos, A. S. M., Nunes, S., Silva, C., Prediger, R. D., Rego, A. C., Ali, S. F., & Ribeiro, C. (2012) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.005 · Cited by 27 · see citing works
Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague–Dawley rats
Asl, S. S., Mousavizedeh, K., Pourheydar, B., Soleimani, M., Rahbarlayegh, E., & Mehdizadeh, M. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9423-1 · Cited by 27 · see citing works
Methamphetamine exposure modulated oxidative status and altered the reproductive output in Daphnia magna
Felice, B. D., Mondellini, S., Salgueiro‐González, N., Castiglioni, S., & Parolini, M. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137728 · Cited by 27 · see citing works
Potential Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress
Chen, L., Ru, Q., Xiong, Q., Yang, J., Xu, G., & Wu, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4445734 · Cited by 25 · see citing works
The OATH Syndemic: opioids and other substances, aging, alcohol, tobacco, and HIV
Womack, J. A., & Justice, A. C. (2020) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000635 · Cited by 26 · see citing works
Telomere length is associated with HIV infection, methamphetamine use, inflammation, and comorbid disease risk
Mehta, S. R., Iudicello, J. E., Lin, J., Ellis, R. J., Morgan, E. E., Okwuegbuna, O. K., Cookson, D. R., Karris, M., Saloner, R., Heaton, R. K., et al. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.108639 · Cited by 24 · see citing works
The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties
Buzhdygan, T. P., Rodrigues, C. R., McGary, H. M., Khan, J. A., Andrews, A. M., Rawls, S. M., & Ramirez, S. H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02116-z · Cited by 24 · see citing works
Tracing Superoxide Anion in Serotonergic Neurons of Living Mouse Brains with Depression by Small-Molecule Fluorescence Probes
Wang, X., Che, F., Zhang, X., Li, P., Zhang, W., & Tang, B. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02701 · Cited by 24 · see citing works
Human Metabolome Changes after a Single Dose of 3,4-Methylenedioxymethamphetamine (MDMA) with Special Focus on Steroid Metabolism and Inflammation Processes
Boxler, M. I., Streun, G. L., Liechti, M. E., Schmid, Y., Kræmer, T., & Steuer, A. E. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00438 · Cited by 24 · see citing works
The Relationship Between Serum Cytokine Levels and the Degree of Psychosis and Cognitive Impairment in Patients With Methamphetamine-Associated Psychosis in Chinese Patients
Yang, X., Zhao, H., Liu, X., Xie, Q., Zhou, X., Deng, Q., & Wang, G. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.594766 · Cited by 23 · see citing works
Dissecting the Influence of Two Structural Substituents on the Differential Neurotoxic Effects of Acute Methamphetamine and Mephedrone Treatment on Dopamine Nerve Endings with the Use of 4-Methylmethamphetamine and Methcathinone
Anneken, J. H., Angoa‐Pérez, M., Sati, G. C., Crich, D., & Kuhn, D. M. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237768 · Cited by 23 · see citing works
Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders
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Substances of abuse and the blood brain barrier: Interactions with physical exercise
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Authors: Yamamoto, B. K., & Raudensky, J.
Affiliations: Boston University (US)
Corresponding author: Yamamoto, Bryan K.
ORCID: Yamamoto, Bryan K.
Venue: Journal of Neuroimmune Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 2008-08-15
Volume: 3
Issue: 4
Pages: 203-217
ISSN: 1557-1890 (ISSN-L)
1557-1904
DOI: 10.1007/s11481-008-9121-7
PMC: PMC3955110
OpenAlex: W2135980918
Cited by: 167
References: 168
Citations by year: 2026: 5 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 18 · 2021: 10 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 16
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Neuroimmune Pharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA007606)
Topics: Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: methamphetamine, MDMA, ecstasy, oxidative stress, mitochondrial dysfunction, neuroinflammation, dopaminergic neurons, serotonergic neurons, neuronal injury, neurotoxicity, drug abuse
MeSH terms: Amphetamines, Animals, Brain, Humans, Inflammation, Neurons, Illicit Drugs, Oxidative Stress

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The Role of Oxidative Stress, Metabolic Compromise, and Inflammation in Neuronal Injury Produced by Amphetamine-Related Drugs of Abuse

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