“Inflammatory” Cytokines: Neuromodulators in Normal Brain?

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

Caput, D., Beutler, B., Hartog, K., Thayer, R. M., Brown-Shimer, S. L., & Cerami, A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1670 · Cited by 1,504

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

Moss, M. L., Jin, S.-L. C., Milla, M. E., Burkhart, W., Carter, H. L., Chen, W.-J., Clay, W. C., Didsbury, J. R., Hassler, D., Hoffman, C. R., et al. (1997) · Nature · doi:10.1038/385733a0 · Cited by 1,378

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297

NF-kB: a crucial transcription factor for glial and neuronal cell function

O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 1,013

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S., Sims, J. E., & Mantovani, A. (1993) · Science · doi:10.1126/science.8332913 · Cited by 979

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

Bruce‐Keller, A. J., Boling, W., Kindy, M. S., Peschon, J. J., Kraemer, P. J., Carpenter, M. K., Holtsberg, F. W., & Mattson, M. P. (1996) · Nature Medicine · doi:10.1038/nm0796-788 · Cited by 934

Cytokines and the nervous system II: actions and mechanisms of action

Rothwell, N. J., & Hopkins, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93890-a · Cited by 922

Tumor Necrosis Factor-α: A Mediator of Focal Ischemic Brain Injury

Barone, F. C., Arvin, B., White, R. F., Miller, A., Webb, C. L., Willette, R. N., Lysko, P. G., & Feuerstein, G. Z. (1997) · Stroke · doi:10.1161/01.str.28.6.1233 · Cited by 863

Cytokines and the nervous system I: expression and recognition

Hopkins, S. J., & Rothwell, N. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80029-2 · Cited by 793

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

Tartaglia, L. A., Weber, R. F., Figari, I. S., Reynolds, C. P., Palladino, M. A., & Goeddel, D. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9292 · Cited by 792

Tumor necrosis factor-alpha expression in ischemic neurons.

Liu, T., Clark, R., Mcdonnell, P., Young, P., White, R. F., Barone, F., & Feuerstein, G. (1994) · Stroke · doi:10.1161/01.str.25.7.1481 · Cited by 782

Characterization of tumor necrosis factor-deficient mice

Marino, M. W., Dunn, A. R., Grail, D., Inglese, M., Noguchi, Y., Richards, E. A., Jungbluth, A., Wada, H., Moore, M. A. S., Williamson, B., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8093 · Cited by 767

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 755

Cytokines in inflammatory brain lesions: helpful and harmful

Merrill, J. E., & Benveniste, E. N. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10047-3 · Cited by 715

A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons

Ericsson, A. B., Kovacs, K., & Sawchenko, P. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 679

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

Cheng, B., Christakos, S., & Mattson, M. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90159-7 · Cited by 660

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

Barger, S. W., Hörster, D., Furukawa, K., Goodman, Y., Krieglstein, J., & Mattson, M. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9328 · Cited by 625

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M., & Iwakura, Y. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1463 · Cited by 611

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease

Boka, G., Anglade, P., Wallach, D., Javoy-Agid, F., Agid, Y., & Hirsch, É. C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90684-x · Cited by 600

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

Arend, W. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115453 · Cited by 594

A neuromodulatory role of interleukin-1β in the hippocampus

Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7778 · Cited by 498

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

Ericsson, A., Liu, C., Hart, R. P., & Sawchenko, P. E. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903610410 · Cited by 471

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460

Visualization and characterization of interleukin 1 receptors in brain.

Farrar, W. L., Kilian, P. L., Ruff, M. R., Hill, J. M., & Pert, C. B. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.2.459 · Cited by 458

Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dememtia

Wesselingh, S. L., Power, C., Glass, J. D., Tyor, W. R., McArthur, J. C., Farber, J. M., Griffin, J. W., & Griffin, D. E. (1993) · Annals of Neurology · doi:10.1002/ana.410330604 · Cited by 414

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

Plata‐Saláman, C. R., Oomura, Y., & Kai, Y. (1988) · Brain Research · doi:10.1016/0006-8993(88)91106-7 · Cited by 413

Constitutive NF-kB Activity in Neurons

Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981-3992.1994 · Cited by 398

Cytokine Actions in the Central Nervous System

Benveniste, E. N. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00015-x · Cited by 383

Immunoregulators in the nervous system

Plata‐Saláman, C. R. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80001-6 · Cited by 381

Inhibition of TNF-induced apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Verma, I. M., & Green, D. R. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01215-4 · Cited by 366

TRANSFORMING GROWTH FACTOR-βS IN NEURODEGENERATIVE DISEASE

FLANDERS, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00066-x · Cited by 364

Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation

Murray, C. A., & Lynch, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02974.1998 · Cited by 359

Cytokine mRNA Profiles in Contused Spinal Cord and Axotomized Facial Nucleus Suggest a Beneficial Role for Inflammation and Gliosis

Streit, W. J., Semple‐Rowland, S. L., Hurley, S. D., Miller, R. C., Popovich, P. G., & Stokes, B. T. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6835 · Cited by 344

Immunoreactive interleukin-1β localization in the rat forebrain

Lechan, R. M., Toni, R., Clark, B. D., Cannon, J. G., Shaw, A. R., Dinarello, C. A., & Reichlin, S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90445-h · Cited by 340

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

Tartaglia, L. A., Rothe, M., Hu, Y.-F., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90222-c · Cited by 339

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

Quan, N., Whiteside, M., & Herkenham, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00350-3 · Cited by 335

Induction of Interleukin‐1β mRNA in Rat Brain After Transient Forebrain Ischemia

Minami, M., Kuraishi, Y., Yabuuchi, K., Yamazaki, A., & Satoh, M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09324.x · Cited by 332

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

Cunningham, E. T., Wada, E., Carter, D., Tracey, D. E., Battey, J., & Souza, E. B. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01101.1992 · Cited by 331

Glial Cell Line-Derived Neurotrophic Factor Protects against Ischemia-Induced Injury in the Cerebral Cortex

Wang, Y., Lin, S., Chiou, A. L., Williams, L. R., & Hoffer, B. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04341.1997 · Cited by 314

Constitutive NF-kappa B activity in neurons.

Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981 · Cited by 304

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA

Talley, A. K., Dewhurst, S., Perry, S. W., Dollard, S. C., Gummuluru, S., Fine, S. M., New, D., Epstein, L. G., Gendelman, H. E., & Gelbard, H. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2359 · Cited by 302

Interleukin-1 receptors in mouse brain: characterization and neuronal localization.

Takao, T., Tracey, D., Mitchell, W., & de Souza, E. D. (1990) · Endocrinology · doi:10.1210/endo-127-6-3070 · Cited by 294

Gene expression and function of interleukin I, interleukin 6 and tumor necrosis factor in the brain

Schöbitz, B., de Kloet, E. R., & Holsboer, F. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90034-5 · Cited by 283

Synthesis of interleukin 1/endogenous pyrogen in the brain of endotoxin-treated mice: a step in fever induction?

Fontana, A., Weber, E., & Dayer, J. M. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.4.1696 · Cited by 277

Receptors for interleukin-1 (α and β) in mouse brain: Mapping and neuronal localization in hippocampus

Ban, E., Milon, G., Prudhomme, N., Fillion, G., & Haour, F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90412-h · Cited by 266

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

Saito, K., Suyama, K., Nishida, K., Sei, Y., & Basile, A. S. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12460-5 · Cited by 257

Induction of tumor necrosis factor-α mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleukin-6

Gatti, S., & Bartfai, T. (1993) · Brain Research · doi:10.1016/0006-8993(93)90090-a · Cited by 257

The Transcription Factor NF‐κB Mediates Increases in Calcium Currents and Decreases in NMDA‐ and AMPA/Kainate‐Induced Currents Induced by Tumor Necrosis Factor‐α in Hippocampal Neurons

Furukawa, K., & Mattson, M. P. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051876.x · Cited by 254

Molecular Basis of Sickness Behaviora

DANTZER, R., BLUTHÉ, R., GHEUSI, G., CREMONA, S., LAYÉ, S., PARNET, P., & KELLEY, K. W. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08321.x · Cited by 249

Involvement of interleukin-1 in immobilization stress-induced increase in plasma adrenocorticotropic hormone and in release of hypothalamic monoamines in the rat

Shintani, F., Nakaki, T., Kanba, S., Sato, K., Yagi, G., Shiozawa, M., Aiso, S., Kato, R., & Asai, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01961.1995 · Cited by 246

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat

Buttini, M., Appel, K., Sauter, A., Gebicke‐Haerter, P. J., & Boddeke, H. W. G. M. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00414-9 · Cited by 243

Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

Mattson, M. P., Barger, S. W., Furukawa, K., Bruce‐Keller, A. J., Wyss‐Coray, T., Mark, R. J., & Mucke, L. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00014-8 · Cited by 243

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

Sheng, J. G., Mrak, R. E., & Griffin, W. S. T. (1998) · Acta Neuropathologica · doi:10.1007/s004010050792 · Cited by 232

Temporal and spatial relationships between lipopolysaccharide-induced expression of fos, interleukin-1 β and inducible nitric oxide synthase in rat brain

Konsman, J. P., Kelley, K. W., & Dantzer, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00368-6 · Cited by 232

Interleukin-10: Biology, Role in Inflammation and Autoimmunity

Lalani, I., Bhol, K. C., & Ahmed, A. R. (1997) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63052-9 · Cited by 230

Distribution and characterization of tumor necrosis factor‐α‐like immunoreactivity in the murine central nervous system

Breder, C. D., Tsujimoto, M., Terano, Y., Scott, D. W., & Saper, C. B. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903370403 · Cited by 226

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

Bandtlow, C. E., Meyer, M., Lindholm, D., Spranger, M., Heumann, R., & Thoenen, H. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.4.1701 · Cited by 221

Pathways and mechanisms for cytokine signaling of the central nervous system.

Licinio, J., & Wong, M. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119846 · Cited by 220

Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain

Fan, L., Young, P. R., Barone, F. C., Feuerstein, G., Smith, D. H., & McIntosh, T. K. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00287-o · Cited by 217

Microbial Products and Cytokines in Sleep and Fever Regulation

Krueger, J. M., & Majde, J. A. (1994) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v14.i3-4.70 · Cited by 213

Involvement of cytokines in normal CNS development and neurological diseases: Recent progress and perspectives

Zhao, B., & Schwartz, J. P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980401)52:1 · Cited by 207

Sleep: A Physiologic Role for IL‐1β and TNF‐αa

Krueger, J. M., Fang, J., Taishi, P., Chen, Z., Kushikata, T., & Gardi, J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08323.x · Cited by 197

Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: A light and electron microscopic study

van Dam, A., Bauer, J., Tilders, F. J. H., & BERKENBOSCH, F. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00549-k · Cited by 189

Delayed cytokine expression in rat brain following experimental contusion

Holmin, S., Schalling, M., Höjeberg, B., Nordqvist, A. S., Skeftruna, A.-K., & Mathiesen, T. I. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.86.3.0493 · Cited by 186

Localization of TNFα and IL-1a immunoreactivities in striatal neurons after surgical injury to the hippocampus

Tchélingérian, J., Quinonero, J., Booss, J., & Jacque, C. (1993) · Neuron · doi:10.1016/0896-6273(93)90312-f · Cited by 185

Localization of type I interleukin-1 receptor mRNA in the rat brain

Yabuuchi, K., Minami, M., Katsumata, S., & Satoh, M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90180-5 · Cited by 184

Lipopolysaccharide enhances synthesis of brain-derived neurotrophic factor in cultured rat microglia

Miwa, T., Furukawa, S., Nakajima, K., Furukawa, Y., & Kohsaka, S. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971215)50:6 · Cited by 181

Nuclear factor-κB/Rel proteins

Grilli, M., & Memo, M. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00214-7 · Cited by 180

Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis.

Gelbard, H., Dzenko, K., Diloreto, D., del Cerro, C., del Cerro, M. D., & Epstein, L. G. (1993) · Developmental Neuroscience · doi:10.1159/000111367 · Cited by 175

Tumor Necrosis Factor-α: a Neuromodulator in the CNS

Pan, W., Zadina, J. E., Harlan, R. E., Weber, J. T., Banks, W. A., & Kastin, A. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00047-4 · Cited by 173

Identification and characterization of receptors for tumor necrosis factor-α in the brain

Kinouchi, K., Brown, G. P., Pasternak, G. W., & Donner, D. B. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92113-x · Cited by 170

Effects of interleukin-1β on sleep are mediated by the type I receptor

Fang, J., Wang, Y., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r655 · Cited by 152

Tumour necrosis factor α and interleukin 1 signalling: do MAPKK kinases connect it all?

Eder, J. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01097-3 · Cited by 148

TGF-β in the central nervous system: Potential roles in ischemic injury and neurodegenerative diseases

Pratt, B. M., & McPherson, J. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00018-x · Cited by 148

Expression of type I and type II interleukin-1 receptors in mouse brain

Parnet, P., Amindari, S., Wu, C., Brunke-Reese, D., Goujon, E., Weyhenmeyer, J. A., Dantzer, R., & Kelley, K. W. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90185-6 · Cited by 142

Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex

da Cunha, A., Jefferson, J. A., Jackson, R. W., & Vitković, L. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90214-j · Cited by 141

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

Wilt, S. G., Milward, E. A., Zhou, J. M., Nagasato, K., Patton, H. M., Rusten, R., Griffin, D. E., O’Connor, M. J., & Dubois-Dalcq, M. E. (1995) · Annals of Neurology · doi:10.1002/ana.410370315 · Cited by 140

Diurnal variation of TNFα in the rat brain

Floyd, R. A., & Krueger, J. M. (1997) · Neuroreport · doi:10.1097/00001756-199703030-00020 · Cited by 138

Interleukin-1β inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C

Plata‐Saláman, C. R., & ffrench‐Mullen, J. M. H. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90202-x · Cited by 137

Induction of interleukin-1β mRNA in adult rat brain

Higgins, G. A., & Olschowka, J. A. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90139-o · Cited by 135

Diurnal variations of interleukin-1β mRNA and β-actin mRNA in rat brain

Taishi, P., Bredow, S., Guha‐Thakurta, N., Obál, F., & Krueger, J. M. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00002-7 · Cited by 132

Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus

Schaaf, M. J. M., Hoetelmans, R. W. M., de Kloet, E. R., & Vreugdenhil, E. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970515)48:4 · Cited by 131

The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra)

Swiergiel, A. H., Smagin, G. N., Johnson, L. J., & Dunn, A. J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01009-3 · Cited by 130

The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro

Coogan, A. N., O'Neill, L. A. J., & O'Connor, J. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00100-1 · Cited by 129

Release of TNFα in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage

de Bock, F., Dornand, J., & Rondouin, G. (1996) · Neuroreport · doi:10.1097/00001756-199604260-00004 · Cited by 121

Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes.

Medana, I. M., Hunt, N. H., & Chaudhri, G. (1997) · Europe PMC (PubMed Central) · Cited by 120

Localization of Interleukin 1 Type I Receptor mRNA in Rat Brain

Wong, M., & Licinio, J. (2006) · NeuroImmunoModulation · doi:10.1159/000097143 · Cited by 118

Neuromodulative actions of cytokines.

Blatteis, C. M. (1990) · PubMed Central · Cited by 117

Diurnal Variations of Tumor Necrosis Factor Alpha mRNA and Alpha-Tubulin mRNA in Rat Brain

Bredow, S., Guha‐Thakurta, N., Taishi, P., Obál, F., & Krueger, J. M. (1997) · NeuroImmunoModulation · doi:10.1159/000097325 · Cited by 111

Cytokines in neuronal cell types

Bartfai, T., & Schultzberg, M. (1993) · Neurochemistry International · doi:10.1016/0197-0186(93)90038-7 · Cited by 111

Localization of Interleukin-1 Receptor Antagonist mRNA in Rat Brain

Licinio, J., Wong, M., & Gold, P. W. (1991) · Endocrinology · doi:10.1210/endo-129-1-562 · Cited by 107

Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells

Plata‐Saláman, C. R., Ilyin, S. E., & Gayle, D. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.2.r566 · Cited by 99

Cytokine‐Induced Anorexia: Behavioral, Cellular, and Molecular Mechanismsa

Plata‐Saláman, C. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08324.x · Cited by 97

Neuronal-associated tumor necrosis factor (TNFα): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration

Ignatowski, T. A., Noble, B. K., Wright, J. R., Gorfien, J. L., Heffner, R. R., & Spengler, R. N. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00107-0 · Cited by 90

Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons

Soliven, B. C., & Albert, J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02665.1992 · Cited by 89

Modulation of IL-1β gene expression in the rat CNS during sleep deprivation

Mackiewicz, M., Sollars, P. J., Ogilvie, M. D., & Pack, A. I. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00037 · Cited by 88

Sleep-Associated Changes in Interleukin-1β mRNA in the Brain

TAISHI, P., CHEN, Z., OBÁL, F., HANSEN, M. K., ZHANG, J., FANG, J., & KRUEGER, J. M. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.793 · Cited by 88

Adenosine: a Mediator of Interleukin-1β-Induced Hippocampal Synaptic Inhibition

Luk, W. P., Zhang, Y., White, T. D., Lue, F. A., Wu, C., Jiang, C., Zhang, L., & Moldofsky, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04238.1999 · Cited by 85

Endotoxin-stimulated production of rat hypothalamic interleukin-1β in vivo and in vitro , measured by specific immunoradiometric assay

Hagan, P., Poole, S., & Bristow, A. F. (1993) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0110031 · Cited by 85

Cytokines in the Central Nervous System: Regulatory Roles in Neuronal Function, Cell Death and Repair

Sei, Y., Vitković, L., & Yokoyama, M. (1995) · NeuroImmunoModulation · doi:10.1159/000096881 · Cited by 85

Astrocyte activation correlates with cytokine production in central nervous system of Trypanosoma brucei brucei-infected mice.

Hunter, C. A., Jennings, F. W., Kennedy, P. G. E., & Murray, M. (1992) · PubMed · Cited by 82

Tumor necrosis factor-α gene expression in the tissues of normal mice

Hunt, J. S., Chen, H.-L., Hu, X.-L., Chen, T.-Y., & Morrison, D. C. (1992) · Cytokine · doi:10.1016/1043-4666(92)90076-4 · Cited by 80

Tumour necrosis factor α and interleukin 1 signalling: do MAPKK kinases connect it all?

Eder, J. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)90657-x · Cited by 78

Control of astrocytosis by interleukin-1 and transforming growth factor-β1 in human brain

da Cunha, A., Jefferson, J. J., Tyor, W. R., Glass, J. D., Jannotta, F. S., & Vitković, L. (1993) · Brain Research · doi:10.1016/0006-8993(93)91183-s · Cited by 77

Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: characterization of brain cytokine and neuropeptide systems mRNAs

Gayle, D. A., Ilyin, S. E., Flynn, M. C., & Plata‐Saláman, C. R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00280-7 · Cited by 76

Developmental expression of cytokine genes in the cortex and hippocampus of the rat central nervous system

Pousset, F. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90078-7 · Cited by 74

Presynaptic inhibitory effect of TNF-α on the release of noradrenaline in isolated median eminence

Elenkov, I. J., Kovács, K., Duda, E., Stark, E., & Vizi, E. S. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90203-w · Cited by 74

Tumor necrosis factor-α: presynaptic sensitivity is modified after antidepressant drug administration

Ignatowski, T. A., & Spengler, R. N. (1994) · Brain Research · doi:10.1016/0006-8993(94)91350-1 · Cited by 72

Interleukin-1β System (Ligand, Receptor Type I, Receptor Accessory Protein and Receptor Antagonist), TNF-α, TGF-β1 and Neuropeptide Y mRNAs in Specific Brain Regions During Bacterial LPS-Induced Anorexia

Ilyin, S. E., Gayle, D. A., Flynn, M. C., & Plata‐Saláman, C. R. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00437-1 · Cited by 71

Dynamic Regulation of Proinflammatory Cytokines

Watkins, L. R., Nguyen, K. T., Lee, J. E., & Maier, S. F. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_10 · Cited by 67

TNFα gene expression is induced in neurones after a hippocampal lesion

Tchélingérian, J., Vignais, L., & Jacque, C. (1994) · Neuroreport · doi:10.1097/00001756-199401000-00013 · Cited by 67

An Interleukin-1-Alpha-Like Neuronal System in the Preoptic-Hypothalamic Region and Its Induction by Bacterial Lipopolysaccharide in Concentrations Which Alter Pituitary Hormone Release

Rettori, V., Dees, W. L., Hiney, J. K., Lyson, K., & McCann, S. M. (2006) · NeuroImmunoModulation · doi:10.1159/000097173 · Cited by 64

Interleukin-1 receptors: cloning studies and role in central nervous system disorders1Published on the World Wide Web on 24 October 1997.1

Loddick, S. A., Liu, C., Takao, T., Hashimoto, K., & Souza, E. B. D. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00037-4 · Cited by 62

Differential Oligodendroglial Expression of the Tumor Necrosis Factor Receptors In Vivo and In Vitro

Tchélingérian, J., Monge, M., Saux, F. L., Zalc, B., & Jacque, C. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052377.x · Cited by 61

Localization of lnterleukln-1 Receptor Messenger RNA in Murlne Hippocampus

Cunningham, E. T., Wada, E., Carter, D. B., Tracey, D. E., Battey, J. F., & Souza, E. B. D. (1991) · Endocrinology · doi:10.1210/endo-128-5-2666 · Cited by 59

Cytokine-induced change in hypothalamic norepinephrine turnover: involvement of corticotropin-releasing hormone and prostaglandins

Terao, A., Oikawa, M., & Saito, M. (1993) · Brain Research · doi:10.1016/0006-8993(93)90826-9 · Cited by 56

Neuroimmunology

Goetzl, E. J., Adelman, D. C., & Sreedharan, S. P. (1990) · Advances in immunology · doi:10.1016/s0065-2776(08)60754-3 · Cited by 56

Neuromodulative Actions of Cytokines

Blatteis, C. M., & Ph., D. (1989) · Cited by 56

The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF‐α

de Bock, F., Dérijard, B., Dornand, J., Bockaert, J., & Rondouin, G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00317.x · Cited by 55

Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-α in the central nervous system

Choe, W., Stoica, G., Lynn, W. S., & Wong, P. K. Y. (1998) · Brain Research · doi:10.1016/s0006-8993(97)00929-3 · Cited by 55

Inhibition of Tumor Necrosis Factor-α Action within the CNS Markedly Reduces the Plasma Adrenocorticotropin Response to Peripheral Local Inflammation in Rats

Turnbull, A. V., Pitossi, F. J., Lebrun, J. J., Lee, S., Meltzer, J. C., Nance, D. M., del Rey, A., Besedovsky, H. O., & RIVIER, C. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03262.1997 · Cited by 52

Gram-negative and gram-positive bacterial products induce differential cytokine profiles in the brain: analysis using an integrative molecular-behavioral in vivo model.

Plata‐Saláman, C. R., Ilyin, S. E., Gayle, D. A., & Flynn, M. C. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm.1.2.387 · Cited by 51

Co-localization of interleukin-1 receptor type I and interleukin-1 receptor antagonist with vasopressin in magnocellular neurons of the paraventricular and supraoptic nuclei of the rat hypothalamus

Diana, A., van Dam, A., Winblad, B. G., & Schultzberg, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00274-7 · Cited by 51

Nitric Oxide Controls the Hypothalamic-Pituitary Response to Cytokines

McCann, S. M., Kimura, M., Karanth, S., Yu, W. H., & Rettori, V. (1997) · NeuroImmunoModulation · doi:10.1159/000097327 · Cited by 47

Tumor necrosis factor-alpha: specific binding sites in rodent brain and pituitary gland.

Wolvers, D. A. W., Marquette, C., BERKENBOSCH, F., & Haour, F. (1993) · PubMed · Cited by 46

Type 2 interleukin-1 receptor mRNA is induced by kainic acid in the rat brain

Nishiyori, A., Minami, M., Takami, S., & Satoh, M. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00195-2 · Cited by 45

Changes in noradrenergic sensitivity to tumor necrosis factor-α in brains of rats administered clonidine

Ignatowski, T. A., Chou, R. C., & Spengler, R. N. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00098-7 · Cited by 45

Detection of lnterleukin-1 Bioactivity in Various Brain Regions of Normal Healthy Rats

Quan, N., Zhang, Z., Emery, M., Bonsall, R. W., & Weiss, J. M. (2006) · NeuroImmunoModulation · doi:10.1159/000097226 · Cited by 44

Interleukin-1 receptors type I and type II in the mouse brain: kinetics of mRNA expressions after peripheral administration of bacterial lipopolysaccharide

Gabellec, M., Griffais, R., Fillion, G., & Haour, F. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(96)00021-5 · Cited by 43

Brain type I but not type II IL-1 receptors mediate the effects of IL-1β on behavior in mice

Cremona, S., Goujon, E., Kelley, K. W., Dantzer, R., & Parnet, P. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r735 · Cited by 42

Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus

Molenaar, G. J., BERKENBOSCH, F., van Dam, A., & Lugard, C. M. J. E. (1993) · Brain Research · doi:10.1016/0006-8993(93)90791-k · Cited by 41

Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice

Layé, S., Goujon, E., Combe, C., VanHoy, R. W., Kelley, K. W., Parnet, P., & Dantzer, R. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(96)00066-5 · Cited by 40

Reduction of cerebellar GABAA responses by interleukin-1 (IL-1) through an indomethacin insensitive mechanism

Pringle, A. K., Gardner, C. R., & Walker, R. J. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00161-1 · Cited by 34

HIV-1 gp120 Modulates Hypothalamic Cytokine mRNAsin Vivo:Implications to Cytokine Feedback Systems

Ilyin, S. E., & Plata‐Saláman, C. R. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6131 · Cited by 34

Selective induction of cytokines in mouse brain infected with canine distemper virus: structural, cellular and temporal expression

Bencsik, A. A., Malcus, C., Akaoka, H., Giraudon, P., Belin, M., & Bernard, A. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00173-5 · Cited by 33

Expression of interleukin-1 receptor antagonist protein in post-mortem human brain tissues of Alzheimer's disease and control cases

Yasuhara, O., Matsuo, A., Terai, K., Walker, D. G., Berger, A. E., Akiguchi, I., Kimura, J., & McGeer, P. L. (1997) · Acta Neuropathologica · doi:10.1007/s004010050633 · Cited by 32

Regionally specific induction of ICE mRNA and enzyme activity in the rat brain and adrenal gland by LPS

Tingsborg, S., Zetterström, M., Alheim, K., Hasanvan, H., Schultzberg, M., & Bartfai, T. (1996) · Brain Research · doi:10.1016/0006-8993(95)01525-6 · Cited by 31

Production of digoxigenin-labelled RNA probes and the detection of cytokine mRNA in rat spleen and brain by in situ hybridization

Meltzer, J. C., Sanders, V., Grimm, P. C., Stern, E. L., RIVIER, C. L., Lee, S., Rennie, S. L., Gietz, R. D., Hole, A. K., Watson, P. H., et al. (1998) · Brain Research Protocols · doi:10.1016/s1385-299x(98)00010-5 · Cited by 29

THE RELEASE OF IMMUNOREACTIVE INTERLEUKIN-1B FROM RAT HYPOTHALAMIC EXPLANTS IS MODULATED BY NEUROTRANSMITTERS AND CORTICOTROPIN-RELEASING HORMONE

Tringali, G., Mirtella, A., Mancuso, C., Guerriero, G., Preziosi, P., & Navarra, P. (1997) · Pharmacological Research · doi:10.1006/phrs.1997.0235 · Cited by 26

Expression of interleukin-1 genes and interleukin-1 receptors in the mouse brain after hippocampal injury

Gabellec, M., Crumeyrolle‐Arias, M., Saux, F. L., Auriou, N., Jacque, C., & Haour, F. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00014-0 · Cited by 25

Blockade of brain type II interleukin-1 receptors potentiates IL1β-induced anorexia in mice

Cremona, S., Layé, S., Dantzer, R., & Parnet, P. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00238-9 · Cited by 25

Tumor Necrosis Factor Receptors in Neuroblastoma SKNBE Cells and Their Regulation by Retinoic Acid

Chambaut‐Guérin, A., Martinez, M., Hamimi, C., Gauthereau, X., & Nunez, J. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65020537.x · Cited by 24

Interleukin-1β has excitatory effects on neurons of the bed nucleus of the stria terminalis

Wilkinson, M. F., Matheison, W. B., & Pittman, Q. J. (1993) · Brain Research · doi:10.1016/0006-8993(93)91079-8 · Cited by 24

Chapter 22 Fever and antipyresis

Kluger, M. J., Kozak, W., Leon, L. R., Soszyński, D., & Conn, C. A. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)62047-6 · Cited by 21

In vivo IL-1β-induced modulation of G-protein αO subunit subclass in the hypothalamic ventromedial nucleus: implications to IL-1β-associated anorexia

Plata‐Saláman, C. R., Wilson, C. D., & ffrench-Mullen, J. M. H. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00126-0 · Cited by 18

Localization of interleukin-1β mRNA in the cerebral ganglion of the protochordate, Styela plicata

Pestarino, M., Anna, E. D., Masini, M. A., & Sturla, M. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)13362-6 · Cited by 15

NF-κB transcription factor subunits in rat brain: Colocalization of p65 and α-MSH

Joseph, S. A., Tassorelli, C., Prasad, A. V., & Lynd‐Balta, E. (1996) · Peptides · doi:10.1016/0196-9781(96)00063-0 · Cited by 14

Differential regulation of brain and plasma TNFα a produced after endotoxin shock

Sacoccio, C., Dornand, J., & Barbanel, G. (1998) · Neuroreport · doi:10.1097/00001756-199801260-00024 · Cited by 11

Microglia as a source and target of cytokines

Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483

Glial activation: a driving force for pathological pain

Watkins, L. R., Milligan, E. D., & Maier, S. F. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01854-3 · Cited by 1,091

Sleep and inflammation: partners in sickness and in health

Irwin, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0190-z · Cited by 1,138

Cytokine signals propagate through the brain

Vitković, L., Konsman, J. P., Bockaert, J., Dantzer, R., Homburger, V., & Jacque, C. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000813 · Cited by 306

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

Vezzani, A., & Viviani, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.027 · Cited by 670

Modulating effect of cytokines on mechanisms of synaptic plasticity in the brain

Levin, S. G., & Godukhin, O. V. (2017) · Biochemistry (Moscow) · doi:10.1134/s000629791703004x · Cited by 139

Cytokine Receptors in the Brain

Conti, B., Tabarean, I. V., Sánchez-Alavez, M., Davis, C., Brownell, S. E., Behrens, M. M., & Bartfai, T. (2008) · Neuroimmune biology · doi:10.1016/s1567-7443(07)10002-8 · Cited by 22

TNFα

Ignatowski, T. A., Noble, B. K., Wright, J. R., Gorfien, J. L., & Spengler, R. N. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0407-4_28 · Cited by 5