Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

Ericsson, A.; Liu, C.; Hart, R. P.; Sawchenko, P. E.

doi:10.1002/cne.903610410

Cited by 471Stress Responses and CortisolNeuroinflammation and Neurodegeneration MechanismsNeuropeptides and Animal Physiology

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

Ericsson, A., Liu, C., Hart, R. P., Sawchenko, P. E.·1995·Journal of Comparative Neurology

DOI 10.1002/cne.903610410

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Abstract

Systemic interleukin‐1 (IL‐1) activates the hypothalamo‐pituitary‐adrenal (HPA) axis, an effect exerted through increased synthesis and secretion of corticotropin‐releasing factor (CRF) by parvicellular neurosecretory neurons. The site(s) and mechanism(s) through which circulat ing IL‐1 may access central systems governing HPA axis output remain obscure. To identify potential cellular targets for blood‐borne IL‐1, we analyzed the distribution of mRNA encoding the rat type 1 IL‐1 receptor (IL‐1R1) in rat brain. Regional ribonuclease protection assays detected a single protected fragment corresponding to the membrane‐bound form of the IL‐1R1 mRNA in all areas analyzed. In situ hybridization revealed labeling predominantly over barrier‐related cells, including the leptomeninges, non‐tanycytic portions of the ependyma, the choroid plexus, and vascular endothelium. Low to moderate levels of the IL‐1111 mRNA were detected in just a few neuronal cell groups, including the basolateral nucleus of the amygdala, the arcuate nucleus of the hypothalamus, the trigeminal and hypoglossal motor nuclei, and the area postrema. No specific labeling for IL‐1R1 mRNA was detected over neurons that respond to intravenous IL‐1β; by induction of transcription factor Fos, including hypophysiotropic CRF cells and brainstem catecholamine neurons. Injection of IL‐1β did, however, provoke induction of mRNA encoding the immediate‐early gene, NGFI‐B, but not c‐fos, in two major loci of IL‐1R1 expression, vascular endothelial cells, and the area postrema. Intravenous inection of IL‐1β acutely down‐regulated IL‐1R1 mRNA in perivascular cells, but not in neuronal cell groups. These results suggest the parenchymal sites of IL‐1R1 expression in rat to be distinct from those reported previously in mouse. The common expression in both species of an IL‐1R in non‐neuronal elements highlights the possibility that IL‐1‐mediated activation of CRF neurons may result from cytokine‐receptor interaction at vascular, and/or other barrier‐related, sites to trigger release of secondary signalling molecules in a position to interact with components of HPA control circuitry. © 1995 Wiley‐Liss, Inc.

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BBB endothelial cells express key cytokine receptors (IL-1R1, IL-6, TNF receptor), and binding of these receptors leads to transport or secretion of additional proinflammatory cytokines and secondary mediators (prostaglandins) that propagate inflammatory signaling into the CNS.
“For instance, BBB endothelial cells express key cytokine receptors (IL-1R1, IL-6, TNF receptor), and binding of these receptors leads to transport or secretion of additional proinflammatory cytokines and secondary mediators (prostaglandins) that propagate inflammatory signaling into the CNS (Bebo and Linthicum, 1995;Ericsson et al, 1995;Vallieres and Rivest, 1999).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Ericsson et al, 1995
CVOs and other CNS barrier tissues can respond to various inflammatory stimuli through expression of cytokine receptors, Toll-like receptors (TLRs), and CD14.
“CVOs and other CNS barrier tissues can, in turn, respond to various inflammatory stimuli through expression of cytokine receptors (103), Toll-like receptors (TLRs) (104), and CD14 (105).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [103]

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689 · see citing works
Interleukin-1 and interleukin-1 antagonism
Dinarello, C. A. (1991) · Blood · doi:10.1182/blood.v77.8.1627.1627 · Cited by 2,303 · see citing works
Expression of c- <i>fos</i> Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925 · see citing works
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519 · see citing works
Untitled work
(1991) · Medical Entomology and Zoology · Cited by 1,512 · see citing works
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504 · see citing works
The use of c-fos as a metabolic marker in neuronal pathway tracing
Dragunow, M., & Faull, R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90150-7 · Cited by 1,416 · see citing works
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
Shu, S., Ju, G., & Fan, L. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90346-1 · Cited by 1,235 · see citing works
Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151 · see citing works
A Complete Protocol for In Situ Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes
Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/his.1989.12.3.169 · Cited by 872 · see citing works
A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons
Ericsson, A. B., Kovacs, K., & Sawchenko, P. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 684 · see citing works
Self-citation
Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells
Bernton, E. W., Beach, J. E., Holaday, J. W., Smallridge, R. C., & Fein, H. G. (1987) · Science · doi:10.1126/science.2821620 · Cited by 671 · see citing works
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene
Milbrandt, J. (1988) · Neuron · doi:10.1016/0896-6273(88)90138-9 · Cited by 661 · see citing works
Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue
Ferreira, S. H., Lorenzetti, B. B., Bristow, A. F., & Poole, S. (1988) · Nature · doi:10.1038/334698a0 · Cited by 624 · see citing works
Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.
Curran, T., Gordon, M. B., Rubino, K. L., & Sambucetti, L. C. (1987) · PubMed · Cited by 623 · see citing works
An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
Bai, F.-L., Yamano, M., Shiotani, Y., Emson, P. C., Smith, A. D., Powell, J. F., & Tohyama, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90730-9 · Cited by 524 · see citing works
Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin
Kilbourn, R. G., & Belloni, P. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.9.772 · Cited by 470 · see citing works
A Complete Protocol for In Situ Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes
Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/014788889794651870 · Cited by 462 · see citing works
Junctions in the meninges and marginal glia.
Nabeshima, S., Reese, T. S., Landis, D. M. D., & Brightman, M. W. (1975) · Journal of Comparative Neurology · doi:10.1002/cne.901640202 · Cited by 444 · see citing works
Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β
Mathias, S., Younes, A., Kan, C.-C., Orlow, I., Joseph, C. K., & Kolesnick, R. (1993) · Science · doi:10.1126/science.8424175 · Cited by 433 · see citing works
Central autonomic pathways
Loewy, A. D. (1990) · Central Regulation of Autonomic Functions · doi:10.1093/oso/9780195051063.003.0006 · Cited by 396 · see citing works
Immunoregulators in the nervous system
Plata‐Saláman, C. R. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80001-6 · Cited by 380 · see citing works
The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1
Colotta, F., Dower, S., Sims, J. E., & Mantovani, A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90217-8 · Cited by 378 · see citing works
INTERLEUKIN-1 STIMULATES ACTH RELEASE BY AN INDIRECT ACTION WHICH REQUIRES ENDOGENOUS CORTICOTROPIN RELEASING FACTOR
Uehara, A., Gottschall, P. E., Dahl, R. R., & Arimura, A. (1987) · Endocrinology · doi:10.1210/endo-121-4-1580 · Cited by 337 · see citing works
In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse
Cunningham, E. T., Wada, E., Carter, D., Tracey, D. E., Battey, J., & Souza, E. B. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01101.1992 · Cited by 334 · see citing works
Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis
Zuckerman, S. H., Shellhaas, J. L., & Butter, L. D. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190213 · Cited by 329 · see citing works
Bidirectional transport of interleukin-1 alpha across the blood-brain barrier
Banks, W. A., Kastin, A. J., & Durham, D. A. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90185-8 · Cited by 325 · see citing works
Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain
Wan, W., Wetmore, L., Sorensen, C. M., Greenberg, A. H., & Nance, D. M. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90179-1 · Cited by 325 · see citing works
Cytokines as modulators of the hypothalamus-pituitary-adrenal axis
Besedovsky, H. O., Del Rey, A., Klusman, I., Furukawa, H., Monge Arditi, G., & Kabiersch, A. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90284-c · Cited by 314 · see citing works
Spatially and temporally differentiated patterns ofc‐fosexpression in brainstem catecholamilriergic cell groups induced by cardiovascular challenges in the rat
Chan, R. K. W., & Sawchenko, P. E. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480309 · Cited by 301 · see citing works
Self-citation
A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry
Chan, R., Brown, E., Ericsson, A., Kovacs, K., & Sawchenko, P. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05126.1993 · Cited by 289 · see citing works
Self-citation
Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat
Wahlestedt, C., Skagerberg, G., Ekman, R., Heilig, M. A., Sundler, F., & Håkanson, R. (1987) · Brain Research · doi:10.1016/0006-8993(87)90176-4 · Cited by 285 · see citing works
Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling
Julius, M., Maroun, C. R., & Haughn, L. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90282-p · Cited by 275 · see citing works
In the Mouse, the Activation of the Hypothalamic Pituitary-Adrenal Axis by a Lipopolysaccharide (Endotoxin) Is Mediated through Interleukin-1*
RIVIER, C. L., Chizzonite, R., & VALE, W. W. (1989) · Endocrinology · doi:10.1210/endo-125-6-2800 · Cited by 273 · see citing works
Receptors for interleukin-1 (α and β) in mouse brain: Mapping and neuronal localization in hippocampus
Ban, E., Milon, G., Prudhomme, N., Fillion, G., & Haour, F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90412-h · Cited by 270 · see citing works
Interleukin 1 receptors in the brain and endocrine tissues
Cunningham, E. T., & Souza, E. B. D. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90281-o · Cited by 230 · see citing works
Stress: Neurobiology and neuroendocrinology
Wolf, S. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90218-a · Cited by 222 · see citing works
Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing
Labiner, D., Butler, L., Cao, Z., Hosford, D. A., Shin, C., & McNamara, J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00744.1993 · Cited by 221 · see citing works
Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release
Katsuura, G., Arimura, A., Köves, K., & Gottschall, P. E. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.1.e163 · Cited by 221 · see citing works
Adrenocorticotropin Release Induced by Intracerebroventricular Injection of Recombinant Human Interleukin-1 in Rats: Possible Involvement of Prostaglandin*
Katsuura, G., Gottschall, P. E., Dahl, R. R., & Arimura, A. (1988) · Endocrinology · doi:10.1210/endo-122-5-1773 · Cited by 217 · see citing works
Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: Stimulation of feeding and the release of corticosterone, vasopressin and glucose
LEIBOWITZ, S. F., Sladek, C. D., Spencer, L., & Tempel, D. L. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90025-1 · Cited by 215 · see citing works
Tumor Necrosis Factor-α is a Potent ACTH Secretagogue: Comparison to Interleukin-1β
Sharp, B. M., Matta, S. G., Peterson, P. K., Newton, R. C., Chao, C. C., & McAllen, K. (1989) · Endocrinology · doi:10.1210/endo-124-6-3131 · Cited by 193 · see citing works
Localization of type I interleukin-1 receptor mRNA in the rat brain
Yabuuchi, K., Minami, M., Katsumata, S., & Satoh, M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90180-5 · Cited by 186 · see citing works
Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat
Coceani, F., Lees, J., & Dinarello, C. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90883-9 · Cited by 178 · see citing works
In the Rat, Interleukin- lα and -β Stimulate Adrenocorticotropin and Catecholamine Release*
RIVIER, C. L., Vale, W., & Brown, M. R. (1989) · Endocrinology · doi:10.1210/endo-125-6-3096 · Cited by 177 · see citing works
Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain
Brady, L. S., Lynn, A. B., Herkenham, M. A., & Gottesfeld, Z. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04951.1994 · Cited by 165 · see citing works
Identification of a high-affinity receptor for interleukin-1 beta in rat brain
Katsuura, G., Gottschall, P. E., & Arimura, A. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80805-2 · Cited by 160 · see citing works
THE MEMBRANOUS COVERINGS OF NEURAL TISSUES: AN ELECTORN MICROSCOPY STUDY
WAGGENER, J. D., & BEGGS, J. (1967) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-196707000-00005 · Cited by 154 · see citing works
Chapter 53: Role of the OVLT in the febrile response to circulating pyrogens
Blatteis, C. M. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)62360-2 · Cited by 153 · see citing works
Influence of the Paraventricular Nucleus of the Hypothalamus in the Alteration of Neuroendocrine Functions Induced by Intermittent Footshock or Interleukin*
Rivest, S., & RIVIER, C. L. (1991) · Endocrinology · doi:10.1210/endo-129-4-2049 · Cited by 147 · see citing works
The distribution and cells of origin of ACTH(1–39)-stained varicosities in the paraventricular and supraoptic nuclei
Sawchenko, P. E., Swanson, L. W., & Joseph, S. (1982) · Brain Research · doi:10.1016/0006-8993(82)90280-3 · Cited by 146 · see citing works
Self-citation
Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus
Suda, T., TOZAWA, F., Iwai, I., Sato, Y., Sumitomo, T., Nakano, Y., Yamada, M., & Demura, H. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90094-6 · Cited by 136 · see citing works
The relationship of efferent projections from the area postrema to vagal motor and brain stem catecholamine-containing cell groups: An axonal transport and immunohistochemical study in the rat
Cunningham, E. T., Miselis, R. R., & Sawchenko, P. E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90087-6 · Cited by 131 · see citing works
Self-citation
The Two Interleukin-1 Receptors Play Different Roles in IL-1 Actions
Sims, J. E., Giri, J. G., & Dower, S. (1994) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1994.1100 · Cited by 128 · see citing works
The effects of recombinant human interleukin (IL)-1α, IL-1β or IL-6 on hypothalamo-pituitary-adrenal axis activation
Harbuz, M. S., Stephanou, A., Sarlis, N. J., & Lightman, S. L. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1330349 · Cited by 123 · see citing works
Opioid inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation of rats.
Plotsky, P. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90022-4 · Cited by 120 · see citing works
Noradrenergic Innervation of the Hypothalamus Participates in Adrenocortical Responses to Interleukin-1
Chuluyán, E., Saphier, D., Rohn, W. M., & Dunn, A. J. (2008) · Neuroendocrinology · doi:10.1159/000126215 · Cited by 119 · see citing works
Differential effects of central and peripheral injection of interleukin-1β on brain c-fos expression and neuroendocrine functions
Rivest, S., Torres, G., & RIVIER, C. L. (1992) · Brain Research · doi:10.1016/0006-8993(92)91424-d · Cited by 119 · see citing works
Localization of Interleukin 1 Type I Receptor mRNA in Rat Brain
Wong, M., & Licinio, J. (2006) · NeuroImmunoModulation · doi:10.1159/000097143 · Cited by 118 · see citing works
Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level
Bauer, J., BERKENBOSCH, F., van Dam, A., & Dijkstra, C. D. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90053-2 · Cited by 115 · see citing works
In situ hybridization study of interleukin-1β mRNA induced by kainic acid in the rat brain
Yabuuchi, K., Minami, M., Katsumata, S., & Satoh, M. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90121-5 · Cited by 114 · see citing works
Evidence for the involvement of the central adrenergic system in interleukin l-induced adrenocortical response
Weidenfeld, J., Abramsky, O., & Ovadia, H. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90018-x · Cited by 100 · see citing works
Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin‐1.
Morimoto, A., Murakami, N., Nakamori, T., Sakata, Y., & Watanabe, T. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017571 · Cited by 99 · see citing works
Reciprocal modulation of interleukin-1 beta (IL-1 beta) and IL-1 receptors by lipopolysaccharide (endotoxin) treatment in the mouse brain-endocrine-immune axis
Takao, T., Culp, S. G., & Souza, E. B. D. (1993) · Endocrinology · doi:10.1210/endo.132.4.8462448 · Cited by 98 · see citing works
An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia
Hart, R. P., Liu, C., Shadiack, A. M., McCormack, R. J., & Jonakait, G. M. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90267-3 · Cited by 95 · see citing works
Self-citation
Intrahypothalamic infusion of interleukin-1β increases the release of corticotropin-releasing hormone (CRH 41) and adrenocorticotropic hormone (ACTH) in free-moving rats bearing a push-pull cannula in the median eminence
Barbanel, G., IXART, G., SZAFARCZYK, A., Malaval, F., & Assebmacher, I. (1990) · Brain Research · doi:10.1016/0006-8993(90)90893-g · Cited by 94 · see citing works
Stromal macrophages of the choroid plexus situated at an interface between the brain and peripheral immune system constitutively express major histocompatibility class II antigens
Matyszak, M. K., Lawson, L. J., Perry, V. H., & Gordon, S. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90131-4 · Cited by 91 · see citing works
Morphology and function of capillary networks in subregions of the rat tuber cinereum
Shaver, S. W., Pang, J. J., Wainman, D. S., Wall, K. M., & Gross, P. M. (1992) · Cell and Tissue Research · doi:10.1007/bf00319366 · Cited by 88 · see citing works
Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes
Deyerle, K. L., Sims, J. E., Dower, S., & Bothwell, M. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.5.1657 · Cited by 87 · see citing works
Neuroendocrine regulation of in vivo cytokine production and effects: I. In vivo regulatory networks involving the neuroendocrine system, interleukin-1 and tumor necrosis factor-α
Butler, L. D., Layman, N. K., Riedl, P. E., Cain, R. L., Shellhaas, J., Evans, G. F., & Zuckerman, S. H. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90108-2 · Cited by 83 · see citing works
The Adrenocorticotropin Response to Interleukin-1β Instilled into the Rat Median Eminence Depends on the Local Release of Catecholamines*
Matta, S. G., SINGH, J., Newton, R. C., & Sharp, B. M. (1990) · Endocrinology · doi:10.1210/endo-127-5-2175 · Cited by 82 · see citing works
Analysis of the ACTH/β-End/α-MSH-Immunoreactive afferent input to the hypothalamic paraventricular nucleus of rat
Kiss, J. Z., Cassell, M. D., & Palkovits, M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90625-5 · Cited by 81 · see citing works
Neuropeptide α-MSH antagonizes IL-6- and TNF-induced fever
Martin, L. W., Catania, A. P., Hiltz, M. E., & Lipton, J. M. (1991) · Peptides · doi:10.1016/0196-9781(91)90015-h · Cited by 75 · see citing works
Passage of immunomodulators across the blood-brain barrier.
Stitt, J. T. (1990) · PubMed · Cited by 73 · see citing works
Identification of the discontinuous binding site in human interleukin 1 beta for the type I interleukin 1 receptor.
Labriola–Tompkins, E., Chandran, C., Kaffka, K. L., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11182 · Cited by 72 · see citing works
A Central Mechanism Is Involved in the Secretion of ACTH in Response to IL-6 in Rats: Comparison to and Interaction with IL-1β
Matta, S. G., Weatherbee, J., & Sharp, B. M. (2008) · Neuroendocrinology · doi:10.1159/000126269 · Cited by 71 · see citing works
INHIBITORY EFFECT OF ADRENOCORTICOTROPIN ON CORTICOTROPIN-RELEASING FACTOR RELEASE FROM RAT HYPOTHALAMUS IN VITRO
Suda, T., Yajima, F., Tomori, N., Sumitomo, T., NAKAGAMI, Y., USHIYAMA, T., Demura, H., & SHIZUME, K. (1986) · Endocrinology · doi:10.1210/endo-118-1-459 · Cited by 61 · see citing works
Central action sites of interleukin‐1 beta for inducing fever in rabbits.
Murakami, N., Sakata, Y., & Watanabe, T. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018213 · Cited by 60 · see citing works
Phaseolus vulgaris Leucoagglutinin Anterograde Axonal Transport Technique
Sawchenko, P. E., Cunningham, E. T., Mortrud, M. T., et al. (1990) · Methods in neurosciences · doi:10.1016/b978-0-12-185255-9.50018-3 · Cited by 49 · see citing works
Self-citation
Circumventricular Organs and Their Role in Visceral Functions
Johnson, A. K., & Loewy, A. D. (1990) · doi:10.1093/oso/9780195051063.003.0014 · Cited by 41 · see citing works
Cellular components of the immune barrier in the spinal meninges and dorsal root ganglia of the normal rat: immunohistochemical (MHC class II) and electron-microscopic observations
Braun, J., Kaissling, B., Hir, M. L., & Zenker, W. (1993) · Cell and Tissue Research · doi:10.1007/bf00312822 · Cited by 40 · see citing works
Combination of in Situ Hybridization with Immunohistochemistry and Retrograde Tract-Tracing
Watts, A. G., & Swanson, L. W. (1989) · Methods in neurosciences · doi:10.1016/b978-0-12-185251-1.50011-8 · Cited by 38 · see citing works
The Pharmacokinetics, Distribution and Degradation of Human Recombinant Interleukin 1β in Normal Rats
Reimers, J., Wogensen, L., Welinder, B., et al. (1991) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1991.tb01583.x · Cited by 38 · see citing works
ACTH response induced in capsaicin‐desensitized rats by intravenous injection of interleukin‐1 or prostaglandin E.
Watanabe, T., Morimoto, A., Tan, N., Makisumi, T., Shimada, S. G., Nakamori, T., & Murakami, N. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020055 · Cited by 33 · see citing works
Passage of Immunomodulators Across the Blood-Brain Barrier
Stitt, J. T., & Ph., D. (1989) · Cited by 33 · see citing works
Regulation of interleukin-1 receptors and hypothalamic-pituitary-adrenal axis by lipopolysaccharide treatment in the mouse
Takao, T., Nakata, H., Tojo, C., Kurokawa, H., Nishioka, T., Hashimoto, K., & Souza, E. B. D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91073-1 · Cited by 22 · see citing works
Chapter 52: The role of OVLT in fever and antipyresis
Zeisberger, E., & Merker, G. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)62359-6 · Cited by 20 · see citing works
Establishment of dye-uptake method (A375 assay) for quantitative measurement of IL-1: correlation with LAF assay.
Nakano, K., Okugawa, K., Hayashi, H., et al. (1988) · PubMed · Cited by 13 · see citing works
c-fos-Based Functional Mapping of Central Pathways Subserving Effects of Interleukin 1 on the Hypothalamo–Pituitary–Adrenal Axis
Ericsson, A. B., & Sawchenko, P. E. (1993) · Methods in neurosciences · doi:10.1016/b978-0-12-185281-8.50015-6 · Cited by 11 · see citing works
Self-citation
Responsiveness of rats to interleukin-1: Effects of monosodium glutamate treatment of neonates
Opp, M. R., Obál, F., Payne, L., et al. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90343-3 · Cited by 11 · see citing works

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Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works
The blood-brain barrier in systemic inflammation
Varatharaj, A., & Galea, I. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.010 · Cited by 1,172 · see citing works
Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
Dantzer, R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.040 · Cited by 743 · see citing works
The Effects of Psychological Stress on Depression
Yang, L., Zhao, Y., Wang, Y., Liu, L., Zhang, X., Li, B., & Cui, R. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831150507 · Cited by 589 · see citing works
“Inflammatory” Cytokines: Neuromodulators in Normal Brain?
Vitkovic, L., Bockaert, J., & Jacque, C. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740457.x · Cited by 506 · see citing works
A neuromodulatory role of interleukin-1β in the hippocampus
Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7778 · Cited by 498 · see citing works
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
Yamamoto, H., Lee, C. E., Marcus, J. N., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L., Saper, C. B., Drucker, D. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215595 · Cited by 429 · see citing works
Immune–neural connections: how the immune system’s response to infectious agents influences behavior
McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429 · see citing works
Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?
Dantzer, R., Konsman, J.-P., Bluthé, R.-M., & Kelley, K. W. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00220-4 · Cited by 400 · see citing works
The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection
Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380 · see citing works
NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Neural-immune interactions in health and disease.
Sternberg, E. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119807 · Cited by 363 · see citing works
Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation
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Lacroix, S., & Rivest, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020452.x · Cited by 280 · see citing works
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Autonomic neural regulation of immunity
CZURA, C. J., & TRACEY, K. J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01442.x · Cited by 255 · see citing works
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Self-citation
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Cano, G., Sved, A. F., Rinaman, L., Rabin, B. S., & Card, J. P. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1331 · Cited by 237 · see citing works
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Burfeind, K. G., Michaelis, K. A., & Marks, D. L. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.10.038 · Cited by 156 · see citing works
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Kishi, T., Aschkenasi, C. J., Choi, B. J., Lopez, M. E., Lee, C. E., Liu, H., Hollenberg, A. N., Friedman, J. M., & Elmquist, J. K. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20432 · Cited by 119 · see citing works
Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice
Somm, E., Henrichot, E., Pernin, A., Juge-Aubry, C. E., Muzzin, P., Dayer, J.-M., Nicklin, M. J. H., & Meier, C. A. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3503 · Cited by 114 · see citing works
Interleukin‐1β modulates state‐dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation
Alam, M. N., McGinty, D., Bashir, T., Kumar, S., Imeri, L., Opp, M. R., & Szymusiak, R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03469.x · Cited by 108 · see citing works
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Saha, S., Engström, L., Mackerlova, L., Jakobsson, P.-J., & Blomqvist, A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00872.2004 · Cited by 108 · see citing works
Interleukins, Inflammation, and Mechanisms of Alzheimer's Disease
Weisman, D., Hakimian, E., & Ho, G. J. (2006) · Vitamins & Hormones · doi:10.1016/s0083-6729(06)74020-1 · Cited by 95 · see citing works
Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation
Rummel, C., Inoue, W., Poole, S., & Luheshi, G. N. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.98 · Cited by 88 · see citing works
Brain structures implicated in inflammation-associated depression
Harrison, N. A. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_30 · Cited by 74 · see citing works
Neural and endocrine mechanisms underlying stress-induced suppression of pulsatile LH secretion
McCosh, R. B., Breen, K. M., & Kauffman, A. S. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110579 · Cited by 65 · see citing works
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Miyata, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.991779 · Cited by 66 · see citing works
Neuroimmune stress responses: reciprocal connections between the hypothalamus and the brainstem
Buller, K. M. (2003) · Stress · doi:10.1080/1025389031000092313 · Cited by 41 · see citing works

Authors: Ericsson, A., Liu, C., Hart, R. P., & Sawchenko, P. E.
Affiliations: Salk Institute for Biological Studies (US)
Rutgers, The State University of New Jersey (US)
Corresponding author: Sawchenko, P. E.
ORCID: Ericsson, A.
Hart, R. P.
Sawchenko, P. E.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1995-10-30
Volume: 361
Issue: 4
Pages: 681-698
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903610410
OpenAlex: W2037280691
Cited by: 471
References: 94
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 12
FWCI: 11.93
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3268 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k02mh000855-02, 5r01mh051564-03)
National Institute of Mental Health (MH51564, MH-00855)
Fogarty International Center
National Institute of Neurological Disorders and Stroke (NS21182)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: IL1R1, IL-1β, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, area postrema, choroid plexus, vascular endothelium, leptomeninges, ependyma, Nur77, c-fos, receptor down-regulation, blood-brain barrier, rat brain
MeSH terms: Animals, Brain, Hypothalamo-Hypophyseal System, Immunohistochemistry, Interleukin-1, Male, Pituitary-Adrenal System, RNA, Messenger, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Interleukin-1, Rats

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Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

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