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Cited by 243Nerve injury and regenerationParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF

Cohen, Ann D., Tillerson, Jennifer L., Smith, Amanda D., Schallert, Timothy, Zigmond, Michael J.·2003·Journal of Neurochemistry
DOI 10.1046/j.1471-4159.2003.01657.x
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Abstract

Unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) causes a loss of dopamine (DA) in the ipsilateral striatum and contralateral motor deficits. However, if a cast is placed on the ipsilateral limb during the first 7 days following 6-OHDA infusion, forcing the animal to use its contralateral limb, both the behavioral and neurochemical deficits are reduced. Here, we examine the effect of forced reliance on a forelimb during the 7 days prior to ipsilateral infusion of 6-OHDA on the deficits characteristic of this lesion model. Casted animals displayed no behavioral asymmetries as measured 14-28 days postlesion and a marked attenuation in the loss of striatal DA and its metabolites at 30 days. In addition, animals receiving a unilateral cast alone had an increase in glial cell-line derived neurotrophic factor (GDNF) protein in the striatum corresponding to the overused limb. GDNF increased within 1 day after the onset of casting, peaked at 3 days, and returned to baseline within 7 days. These results suggest that preinjury forced limb-use can prevent the behavioral and neurochemical deficits to the subsequent administration of 6-OHDA and that this may be due in part to neuroprotective effects of GDNF.

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Crossref · 10.1046/j.1471-4159.2003.01657.x

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Research works printed but not linked: 2

  1. Paxinos G., 1982, The Rat Brain in Sterotaxic Coordinates
  2. Schallert T., 1989, Preoperative Events: Their Effects on Behavior Following Brain Damage, 1

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Metadata

Authors
Cohen, A. D., Tillerson, J. L., Smith, A. D., Schallert, T., & Zigmond, M. J.
Affiliations
  • University of Pittsburgh (US)
  • The University of Texas at Austin (US)
  • University of Michigan (US)
Corresponding author
Zigmond, Michael J.
ORCID
Cohen, Ann D.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2003-04
Volume
85
Issue
2
Pages
299-305
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1046/j.1471-4159.2003.01657.x
OpenAlex
W2131124574
Cited by
243
References
52
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 19 · 2012: 5
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns023979-15)
  • U.S. Public Health Service
  • National Institute of Mental Health (MH-29670)
  • National Institute of Neurological Disorders and Stroke (NS 19608, NS 23979, T32NS007433, NS 07433)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
6-hydroxydopamine, medial forebrain bundle lesion, dopamine depletion, striatum, glial cell line-derived neurotrophic factor, neuroprotection, motor impairment, behavioral asymmetry, dopamine metabolites
MeSH terms
Animals, Apomorphine, Behavior, Animal, Casts, Surgical, Corpus Striatum, Disease Models, Animal, Dopamine, Forelimb, Immobilization, Functional Laterality, Male, Medial Forebrain Bundle, Motor Activity, Nerve Growth Factors, Parkinson Disease, Secondary, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats, Sprague-Dawley, Rats, Long-Evans, Glial Cell Line-Derived Neurotrophic Factor, Rats

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