CoChat
Sign Up
Cited by 243Nerve injury and regenerationParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF

Cohen, Ann D., Tillerson, Jennifer L., Smith, Amanda D., Schallert, Timothy, Zigmond, Michael J.·2003·Journal of Neurochemistry
DOI 10.1046/j.1471-4159.2003.01657.x
Open this paper in CoChat — free account

Abstract

Unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) causes a loss of dopamine (DA) in the ipsilateral striatum and contralateral motor deficits. However, if a cast is placed on the ipsilateral limb during the first 7 days following 6-OHDA infusion, forcing the animal to use its contralateral limb, both the behavioral and neurochemical deficits are reduced. Here, we examine the effect of forced reliance on a forelimb during the 7 days prior to ipsilateral infusion of 6-OHDA on the deficits characteristic of this lesion model. Casted animals displayed no behavioral asymmetries as measured 14-28 days postlesion and a marked attenuation in the loss of striatal DA and its metabolites at 30 days. In addition, animals receiving a unilateral cast alone had an increase in glial cell-line derived neurotrophic factor (GDNF) protein in the striatum corresponding to the overused limb. GDNF increased within 1 day after the onset of casting, peaked at 3 days, and returned to baseline within 7 days. These results suggest that preinjury forced limb-use can prevent the behavioral and neurochemical deficits to the subsequent administration of 6-OHDA and that this may be due in part to neuroprotective effects of GDNF.

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1471-4159.2003.01657.x

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Paxinos G., 1982, The Rat Brain in Sterotaxic Coordinates
  2. Schallert T., 1989, Preoperative Events: Their Effects on Behavior Following Brain Damage, 1

Cited by

Sorted by citations

See all 243

Related

See all

Metadata

Authors
Cohen, A. D., Tillerson, J. L., Smith, A. D., Schallert, T., & Zigmond, M. J.
Affiliations
  • University of Pittsburgh (US)
  • The University of Texas at Austin (US)
  • University of Michigan (US)
Corresponding author
Zigmond, Michael J.
ORCID
Cohen, Ann D.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2003-04
Volume
85
Issue
2
Pages
299-305
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
DOI
10.1046/j.1471-4159.2003.01657.x
OpenAlex
W2131124574
Cited by
243
References
52
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 19 · 2012: 5
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns023979-15)
  • U.S. Public Health Service
  • National Institute of Mental Health (MH-29670)
  • National Institute of Neurological Disorders and Stroke (NS 19608, NS 23979, T32NS007433, NS 07433)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
6-hydroxydopamine, medial forebrain bundle lesion, dopamine depletion, striatum, glial cell line-derived neurotrophic factor, neuroprotection, motor impairment, behavioral asymmetry, dopamine metabolites
MeSH terms
Animals, Apomorphine, Behavior, Animal, Casts, Surgical, Corpus Striatum, Disease Models, Animal, Dopamine, Forelimb, Immobilization, Functional Laterality, Male, Medial Forebrain Bundle, Motor Activity, Nerve Growth Factors, Parkinson Disease, Secondary, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats, Sprague-Dawley, Rats, Long-Evans, Glial Cell Line-Derived Neurotrophic Factor, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review