Cited by 243Nerve injury and regenerationParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

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Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF

Cohen, Ann D., Tillerson, Jennifer L., Smith, Amanda D., Schallert, Timothy, Zigmond, Michael J.·2003·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.2003.01657.x

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Abstract

Unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) causes a loss of dopamine (DA) in the ipsilateral striatum and contralateral motor deficits. However, if a cast is placed on the ipsilateral limb during the first 7 days following 6-OHDA infusion, forcing the animal to use its contralateral limb, both the behavioral and neurochemical deficits are reduced. Here, we examine the effect of forced reliance on a forelimb during the 7 days prior to ipsilateral infusion of 6-OHDA on the deficits characteristic of this lesion model. Casted animals displayed no behavioral asymmetries as measured 14-28 days postlesion and a marked attenuation in the loss of striatal DA and its metabolites at 30 days. In addition, animals receiving a unilateral cast alone had an increase in glial cell-line derived neurotrophic factor (GDNF) protein in the striatum corresponding to the overused limb. GDNF increased within 1 day after the onset of casting, peaked at 3 days, and returned to baseline within 7 days. These results suggest that preinjury forced limb-use can prevent the behavioral and neurochemical deficits to the subsequent administration of 6-OHDA and that this may be due in part to neuroprotective effects of GDNF.

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Retracted
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Authors: Cohen, A. D., Tillerson, J. L., Smith, A. D., Schallert, T., & Zigmond, M. J.
Affiliations: University of Pittsburgh (US)
The University of Texas at Austin (US)
University of Michigan (US)
Corresponding author: Zigmond, Michael J.
ORCID: Cohen, Ann D.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2003-04
Volume: 85
Issue: 2
Pages: 299-305
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.2003.01657.x
OpenAlex: W2131124574
Cited by: 243
References: 52
Citations by year: 2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 11 · 2014: 17 · 2013: 19 · 2012: 5
FWCI: 4.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns023979-15)
U.S. Public Health Service
National Institute of Mental Health (MH-29670)
National Institute of Neurological Disorders and Stroke (NS 19608, NS 23979, T32NS007433, NS 07433)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: 6-hydroxydopamine, medial forebrain bundle lesion, dopamine depletion, striatum, glial cell line-derived neurotrophic factor, neuroprotection, motor impairment, behavioral asymmetry, dopamine metabolites
MeSH terms: Animals, Apomorphine, Behavior, Animal, Casts, Surgical, Corpus Striatum, Disease Models, Animal, Dopamine, Forelimb, Immobilization, Functional Laterality, Male, Medial Forebrain Bundle, Motor Activity, Nerve Growth Factors, Parkinson Disease, Secondary, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats, Sprague-Dawley, Rats, Long-Evans, Glial Cell Line-Derived Neurotrophic Factor, Rats

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Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF

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