The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge
Open accessAbstract
Putative epithelial stem cells in the hair follicle bulge are thought to play pivotal roles in the homeostasis, aging, and carcinogenesis of the cutaneous epithelium. Elucidating the role of bulge cells in these processes has been hampered by the lack of gene promoters that target this area with specificity. Here we describe the isolation of the mouse keratin 15 (K15) promoter and demonstrate its utility for preferentially targeting hair follicle bulge cells in adult K15/lacZ transgenic mice. We found that patterns of K15 expression and promoter activity changed with age and correlated with levels of differentiation within the cutaneous epithelium; less differentiated keratinocytes in the epidermis of the neonatal mouse and in the bulge area of the adult mouse preferentially expressed K15. These findings demonstrate the utility of the K15 promoter for targeting epithelial stem cells in the hair follicle bulge and set the stage for elucidating the role of bulge cells in skin biology.
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Self-citationFGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
Arnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341
Deregulated expression of c-Myc depletes epidermal stem cells
Waikel, R. L., Kawachi, Y., Waikel, P. A., Wang, X.-J., & Roop, D. R. (2001) · Nature Genetics · doi:10.1038/88889 · Cited by 318
Slowly cycling (label‐retaining) epidermal cells behave like clonogenic stem cells in vitro
Morris, R. J., & Potten, C. S. (1994) · Cell Proliferation · doi:10.1111/j.1365-2184.1994.tb01425.x · Cited by 207
Cited by
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,314
Self-citationCapturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
Self-citationThe Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
Hair follicle stem cells are specified and function in early skin morphogenesis
Nowak, J. A., Polak, L., Pasolli, H. A., & Fuchs, E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.05.009 · Cited by 554
Identification of the cell lineage at the origin of basal cell carcinoma
Youssef, K. K., Van Keymeulen, A., Lapouge, G., Beck, B., Michaux, C., Achouri, Y., Sotiropoulou, P. A., & Blanpain, C. (2010) · Nature Cell Biology · doi:10.1038/ncb2031 · Cited by 401
Metadata
- Authors
- Liu, Y., Lyle, S., Yang, Z., & Cotsarelis, G.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 121
- Issue
- 5
- Pages
- 963-968
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2089631233
- Cited by
- 387
- References
- 5
- FWCI
- 16.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge. https://app.cochat.ai/papers/10.1046/j.1523-1747.2003.12600.x
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- Liu, Y., Lyle, S., Yang, Z., & Cotsarelis, G. (2003). Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge. Journal of Investigative Dermatology. https://doi.org/10.1046/j.1523-1747.2003.12600.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
