The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Advanced glycation end products and mortality in hemodialysis patients
Open accessAbstract
Background Advanced glycation and oxidation end products (AGEs) cause oxidative stress and trigger cytokine driven inflammatory reactions in vitro. The net effects on markers of inflammation and acute phase proteins in vivo as well as their influence on survival in hemodialysis patients are unknown.Methods We conducted a cross-sectional study in 312 stable hemodialysis patients and analyzed the interrelationships of AGEs and C-reactive protein (CRP) and their predictive effect on all-cause as well as cardiovascular mortality. Mortality was monitored prospectively over a period of 32 months. AGEs were determined by measuring total serum fluorescent AGEs (AGE-fl) and Nepsilon-(carboxymethyl)-lysine (CML).Results The levels of AGE-fl, CML and CRP were 3.2-, 3.8- and 10-fold higher as compared to healthy controls. AGE-fl and CML levels correlated significantly with each other but not with CRP or serum albumin. Patients with high (above median values) AGE-fl or CML levels (109 x 103 AU and 1.4 microg/mL, respectively) had a significant better survival than those with low (below median values) AGE-fl or CML levels. Patients with high CRP levels (above 7.7 mg/L = median value) had a better survival than those with low CRP (below median value) when AGE-fl or CML levels were high in parallel.Conclusions In contrast to in vitro data and to current hypotheses, the presence of high serum AGEs, as measured by AGE-fl and CML, were not linked to increased mortality. Statistically, high serum AGEs partly overcame the negative impact of the acute phase response on mortality in hemodialysis patients. Whether the benefit of high serum AGEs is an epiphenomenon or reflects a better nutritional support needs further studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“During heavy exercise, such as a marathon, there is up to a 60-fold increase in plasma IL-6 concentration (209) , with the duration of the event explaining more than 50 % of the variation in concentration (210) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [210]
Citations
Cites
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692
Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531
Self-citationAdvanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312
Advanced Glycosylation End Products in Patients with Diabetic Nephropathy
Makita, Z., Radoff, S., Rayfield, E. J., Yang, Z. H., Skolnik, E. Y., DELANEY, V. B., Friedman, E. A., Cerami, A., & Vlassara, H. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109193251202 · Cited by 922
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9982 · Cited by 822
Koschinsky, T., He, C.-J., Mitsuhashi, T., Bucala, R., Liu, C., Buenting, C., Heitmann, K., & Vlassara, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6474 · Cited by 792
Schleicher, E. D., Wagner, E., & Nerlich, A. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119180 · Cited by 714
Thornalley, P. J. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02054-3 · Cited by 591
C-Reactive Protein in the Arterial Intima
Torzewski, M., Rist, C., Mortensen, R. F., Zwaka, T. P., Bienek, M., Waltenberger, J. L., Köenig, W., Schmitz, G., Hombach, V., & Torzewski, J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2094 · Cited by 585
Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 554
Reddy, S., Bichler, J., Wells‐Knecht, K. J., Thorpe, S. R., & Baynes, J. (1995) · Biochemistry · doi:10.1021/bi00034a021 · Cited by 524
Miyata, T., de Strihou, C. V. Y., Kurokawa, K., & Baynes, J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00302.x · Cited by 521
Shinohara, M., Thornalley, P. J., Giardino, I., Beisswenger, P. J., Thorpe, S. R., Onorato, J., & Brownlee, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119885 · Cited by 513
Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure
Makita, Z., Bucala, R., Rayfield, E. J., Fuh, H., Manogue, K. R., Cerami, A., Viassara, H., Friedman, E. A., Kaufman, A. M., Korbet, S. M., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92935-1 · Cited by 376
Münch, G. W., Keis, R., Weßels, A., Riederer, P. F., Bahner, U., Heidland, A., Niwa, T., Lemke, H., & Schinzel, R. (1997) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1997.35.9.669 · Cited by 313
Self-citationMechanisms of hypoalbuminemia in hemodialysis patients
Kaysen, G. A., Rathore, V., Shearer, G. C., & Depner, T. A. (1995) · Kidney International · doi:10.1038/ki.1995.321 · Cited by 295
Advanced glycation end products: A nephrologist's perspective
Raj, D. S., Choudhury, D., Welbourne, T., & Levi, M. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70189-2 · Cited by 288
Inflammatory Markers of Coronary Risk
Rader, D. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431609 · Cited by 262
Giardino, I., Edelstein, D., & Brownlee, M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118563 · Cited by 258
Chromatographic Quantitation of Plasma and Erythrocyte Pentosidine in Diabetic and Uremic Subjects
Odetti, P. R., Fogarty, J., Sell, D. R., & Monnier, V. M. (1992) · Diabetes · doi:10.2337/diab.41.2.153 · Cited by 255
Gugliucci, A., & Bendayan, M. (1996) · Diabetologia · doi:10.1007/bf00403957 · Cited by 247
Renal catabolism of advanced glycation end products: the fate of pentosidine
Miyata, T., Ueda, Y., Horie, K., Nangaku, M., Tanaka, S., de Strihou, C. V. Y., & Kurokawa, K. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00756.x · Cited by 227
Hyperhomocysteinemia, nutritional status, and cardiovascular disease in hemodialysis patients
Suliman, M. E., Qureshi, A. R., Barany, P. F., Stenvinkel, P., Filho, J. C. D., Anderstam, B., Heimbürger, O., Lindholm, B., & Bergström, J. P. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00018.x · Cited by 206
Death risk predictors among peritoneal dialysis and hemodialysis patients: A preliminary comparison
Lowrie, E. G., Huang, W., & Lew, N. L. (1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90177-9 · Cited by 180
Mechanisms for the formation of glycoxidation products in end-stage renal disease
Weiss, M. F., Erhard, P., Kader-Attia, F. A., Wu, Y. C., DeOreo, P. B., Araki, A., Glomb, M. A., & Monnier, V. M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00117.x · Cited by 155
Papanastasiou, P., Grass, L., Rodela, H., Patrikarea, A., Oreopoulos, D. G., & Diamandis, E. P. (1994) · Kidney International · doi:10.1038/ki.1994.262 · Cited by 139
Endothelial dysfunctions: common denominators in vascular disease
Caterina, R. D. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200002000-00003 · Cited by 131
Takeuchi, M., Makita, Z., Yanagisawa, K., Kameda, Y., & Koike, T. (1999) · Molecular Medicine · doi:10.1007/bf03402128 · Cited by 122
Nϵ-(carboxymethyl)lysine levels in patients with type 2 diabetes: Role of renal function
Wagner, Z., Wittmann, I., Mazák, I., Schinzel, R., Heidland, A., Kientsch-Engel, R., & Nagy, J. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.27695 · Cited by 104
Self-citationSchwedler, S. B., Schinzel, R., Vaith, P., & Wanner, C. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.59780032.x · Cited by 100
Self-citationHammes, H., Brownlee, M., Lin, J., Schleicher, E., & Bretzel, R. G. (1999) · Diabetologia · doi:10.1007/s001250051201 · Cited by 85
Nɛ-(carboxymethyl)lysine in atherosclerotic vascular lesions as a marker for local oxidative stress
Nerlich, M. L. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00038-6 · Cited by 84
Advanced Glycation End Products in End-Stage Renal Disease and Their Removal
Schinzel, R., Münch, G. W., Heidland, A., & Šebeková, K. (2001) · The Nephron journals/Nephron journals · doi:10.1159/000045934 · Cited by 57
Self-citationThe pathogenesis and consequences of AGE formation in uraemia and its treatment.
Dawnay, A., & Millar, D. J. (1998) · PubMed · Cited by 41
Immunological determination of advanced glycosylation end-products in human blood and urine
DOLHOFER, R., Lechner, B., Deppisch, R. M., Ritz, E., & Gerbitz, K.-D. (1995) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/10.5.657 · Cited by 40
Zoccali, C., Mallamaci, F., Asahia, K., Benedetto, F. A., Tripepi, G. L., Tripepi, R., Nicocia, G., Buemi, M., & Miyata, T. (2001) · PubMed · Cited by 35
The Maillard reaction--from food chemistry to uraemia research
Henle, T., Deppisch, R. M., & Ritz, E. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/oxfordjournals.ndt.a027655 · Cited by 17
The Maillard reaction—from food chemistry to uraemia research
Henle, T., Deppisch, R. M., & Ritz, E. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.9.1718 · Cited by 4
Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Ketteler, M., Bongartz, P., Westenfeld, R., Wildberger, J. E., Mahnken, A. H., Böhm, R. O. B., Metzger, T., Wanner, C., Jahnen‐Dechent, W., & Floege, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12710-9 · Cited by 909
Self-citationOxidative stress in end-stage renal disease: an emerging threat to patient outcome
Locatelli, F., Canaud, B., Eckardt, K., Stenvinkel, P., Wanner, C., & Zoccali, C. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg074 · Cited by 761
Self-citationAdvanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient
Stenvinkel, P., Carrero, J. J., Axelsson, J., Lindholm, B., Heimbürger, O., & Massy, Z. A. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03670807 · Cited by 577
Metadata
- Authors
- Schwedler, S. B., Metzger, T., Schinzel, R., & Wanner, C.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Wanner, Christoph
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 62
- Issue
- 1
- Pages
- 301-310
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2013180282
- Cited by
- 195
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- advanced glycation end products, hemodialysis patients, mortality, C-reactive protein, carboxymethyllysine, acute phase response, inflammation, cardiovascular mortality, all-cause mortality, survival
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aspirin, C-Reactive Protein, Female, Renal Dialysis, Humans, Lysine, Male, Middle Aged, Serum Albumin, Survival Rate, Glycation End Products, Advanced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
