The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Advanced glycation end products and mortality in hemodialysis patients
Open accessAbstract
Background Advanced glycation and oxidation end products (AGEs) cause oxidative stress and trigger cytokine driven inflammatory reactions in vitro. The net effects on markers of inflammation and acute phase proteins in vivo as well as their influence on survival in hemodialysis patients are unknown.Methods We conducted a cross-sectional study in 312 stable hemodialysis patients and analyzed the interrelationships of AGEs and C-reactive protein (CRP) and their predictive effect on all-cause as well as cardiovascular mortality. Mortality was monitored prospectively over a period of 32 months. AGEs were determined by measuring total serum fluorescent AGEs (AGE-fl) and Nepsilon-(carboxymethyl)-lysine (CML).Results The levels of AGE-fl, CML and CRP were 3.2-, 3.8- and 10-fold higher as compared to healthy controls. AGE-fl and CML levels correlated significantly with each other but not with CRP or serum albumin. Patients with high (above median values) AGE-fl or CML levels (109 x 103 AU and 1.4 microg/mL, respectively) had a significant better survival than those with low (below median values) AGE-fl or CML levels. Patients with high CRP levels (above 7.7 mg/L = median value) had a better survival than those with low CRP (below median value) when AGE-fl or CML levels were high in parallel.Conclusions In contrast to in vitro data and to current hypotheses, the presence of high serum AGEs, as measured by AGE-fl and CML, were not linked to increased mortality. Statistically, high serum AGEs partly overcame the negative impact of the acute phase response on mortality in hemodialysis patients. Whether the benefit of high serum AGEs is an epiphenomenon or reflects a better nutritional support needs further studies.
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“During heavy exercise, such as a marathon, there is up to a 60-fold increase in plasma IL-6 concentration (209) , with the duration of the event explaining more than 50 % of the variation in concentration (210) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [210]
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Self-citationAdvanced protein glycosylation in diabetes and aging
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Ketteler, M., Bongartz, P., Westenfeld, R., Wildberger, J. E., Mahnken, A. H., Böhm, R. O. B., Metzger, T., Wanner, C., Jahnen‐Dechent, W., & Floege, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12710-9 · Cited by 909
Self-citationOxidative stress in end-stage renal disease: an emerging threat to patient outcome
Locatelli, F., Canaud, B., Eckardt, K., Stenvinkel, P., Wanner, C., & Zoccali, C. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg074 · Cited by 761
Self-citationAdvanced glycation endproducts in food and their effects on health
Poulsen, M. W., Hedegaard, R. V., Andersen, J. M., de Courten, B., Bügel, S., Nielsen, J., Skibsted, L. H., & Dragsted, L. O. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.052 · Cited by 751
Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient
Stenvinkel, P., Carrero, J. J., Axelsson, J., Lindholm, B., Heimbürger, O., & Massy, Z. A. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03670807 · Cited by 577
Metadata
- Authors
- Schwedler, S. B., Metzger, T., Schinzel, R., & Wanner, C.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Wanner, Christoph
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 62
- Issue
- 1
- Pages
- 301-310
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2013180282
- Cited by
- 195
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- advanced glycation end products, hemodialysis patients, mortality, C-reactive protein, carboxymethyllysine, acute phase response, inflammation, cardiovascular mortality, all-cause mortality, survival
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aspirin, C-Reactive Protein, Female, Renal Dialysis, Humans, Lysine, Male, Middle Aged, Serum Albumin, Survival Rate, Glycation End Products, Advanced
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