The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Acetoacetate, Acetone, and Dibenzylamine (a Contaminant in l‐(+)‐β‐Hydroxybutyrate) Exhibit Direct Anticonvulsant Actions in Vivo
Abstract
Summary: Purpose: To investigate whether ketone bodies are directly anticonvulsant. Methods: We tested the effects of acetoacetate (ACA), acetone, and both stereoisomers, d‐(−)‐ and l‐(+), of β‐hydroxybutyrate (BHB) on sensory‐evoked seizures in Frings audiogenic seizure‐susceptible mice. Results: We found that these ketone bodies, with the exception of the d‐(−)‐isomer of BHB, were anticonvulsant in this model. Furthermore, with gas chromatography–mass spectrometry, we confirmed that the activity of l‐(+)‐BHB was due to dibenzylamine, a chemical contaminant. Conclusions: Our data indicate that the anticonvulsant efficacy of the ketogenic diet may be due in part to the direct actions of ACA and acetone.
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Arafat, E. S., Hargrove, J. T., Maxson, W. S., Desiderio, D. M., Wentz, A. C., & Andersen, R. N. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90448-6 · Cited by 134
Cited by
Anticonvulsant Mechanisms of the Ketogenic Diet
Bough, K. J., & Rho, J. M. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.00915.x · Cited by 523
Self-citationNeuroprotective and disease-modifying effects of the ketogenic diet
Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00009 · Cited by 445
Ketogenic Diet and Epilepsy: What We Know So Far
D’Andrea Meira, I., Romão, T. T., Pires do Prado, H. J., Krüger, L. T., Pires, M. E. P., & da Conceição, P. O. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00005 · Cited by 367
The Ketogenic Diet: One Decade Later
Freeman, J. M., Kossoff, E. H., & Hartman, A. L. (2007) · Pediatrics · doi:10.1542/peds.2006-2447 · Cited by 364
The Neuropharmacology of the Ketogenic Diet
Hartman, A. L., Gasior, M., Vining, E. P. G., & Rogawski, M. A. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.02.008 · Cited by 325
Metadata
- Authors
- Rho, J. M., Anderson, G. D., Donevan, S. D., & White, H. S.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 43
- Issue
- 4
- Pages
- 358-361
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2095586613
- Cited by
- 158
- References
- 1
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rho, J. M., Anderson, G. D., Donevan, S. D., & White, H. S. (2002). Acetoacetate, Acetone, and Dibenzylamine (a Contaminant in l‐(+)‐β‐Hydroxybutyrate) Exhibit Direct Anticonvulsant Actions in Vivo. Epilepsia. https://doi.org/10.1046/j.1528-1157.2002.47901.x
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