Cited by 170Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

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Molecular Genetics of Late‐Onset Alzheimer's Disease

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Kamboh, M. Ilyas·2004·Annals of Human Genetics

DOI 10.1046/j.1529-8817.2004.00110.x

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Abstract

Summary: Late‐onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE*4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late‐onset AD. However, as the APOE*4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE*4, can modify the risk of AD. Recently, genome‐wide linkage or linkage disequilibrium studies on late‐onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late‐onset AD.

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Authors: Kamboh, M. I.
Affiliations: University of Pittsburgh (US)
Corresponding author: Kamboh, M. Ilyas
ORCID: Kamboh, M. Ilyas
Venue: Annals of Human Genetics
Publisher: Wiley
Published: 2004-06-28
Volume: 68
Issue: 4
Pages: 381-404
ISSN: 0003-4800 (ISSN-L)
1469-1809
DOI: 10.1046/j.1529-8817.2004.00110.x
OpenAlex: W2137932456
Cited by: 170
References: 131
Citations by year: 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 12
FWCI: 2.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Human Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 05-133, P50AG005133, AG13672, R01AG013672)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: late-onset Alzheimer's disease, apolipoprotein E, genetic susceptibility, genetic loci, genome-wide linkage analysis, linkage disequilibrium, complex diseases, genetic risk factors
MeSH terms: Alzheimer Disease, Apolipoproteins E, Humans, Genetic Linkage, Molecular Biology, Biomarkers

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Molecular Genetics of Late‐Onset Alzheimer's Disease

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