Cited by 170Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.

Molecular Genetics of Late‐Onset Alzheimer's Disease

Open access

Kamboh, M. Ilyas·2004·Annals of Human Genetics

DOI 10.1046/j.1529-8817.2004.00110.x

Open this paper in CoChat — free account Open PDF

Abstract

Summary: Late‐onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE*4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late‐onset AD. However, as the APOE*4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE*4, can modify the risk of AD. Recently, genome‐wide linkage or linkage disequilibrium studies on late‐onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late‐onset AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.1529-8817.2004.00110.x

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Sørlie, T., Perou, C. M., Tibshirani, R. J., Aas, T., Geisler, S. B., Johnsen, H., Hastie, T. J., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191367098 · Cited by 11,506
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051
Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818
Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters
Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J. R., Kwiterovich, P. O., Shan, B., Barnes, R., & Hobbs, H. H. (2000) · Science · doi:10.1126/science.290.5497.1771 · Cited by 1,645
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526
Uber eine eigenartige Erkrankung der Hirnrinde
Alzheimer, A. (1907) · Medical Entomology and Zoology · Cited by 1,503
Alzheimer's Disease and Parkinson's Disease
Nussbaum, R. L., & Ellis, C. E. (2003) · New England Journal of Medicine · doi:10.1056/nejm2003ra020003 · Cited by 1,351
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · cited 1×
“OLR1 also binds to apoptotic cells (Oka et al. 1998; Kataoka et al. 2001) and since neuronal apoptosis is common in AD patients (West et al. 1994; Friedlander 2003), it can affect the risk of AD by its involvement in the mechanism of cell death.”
Background
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937
Apoptosis and Caspases in Neurodegenerative Diseases
Friedlander, R. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022366 · Cited by 873
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
Lawn, R. M., Wade, D. P., Garvin, M. R., Wang, X., Schwartz, K., Porter, J. G., Seilhamer, J. J., Vaughan, A. M., & Oram, J. F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8119 · Cited by 724
Molecular characterisation of soft tissue tumours: a gene expression study
Nielsen, T. O., West, R. B., Linn, S. C., Alter, O., Knowling, M. A., OʼConnell, J. X., Zhu, S., Fero, M., Sherlock, G. J., Pollack, J. R., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08270-3 · Cited by 574
Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients
van Leeuwen, F. W., de Kleijn, D. P. V., van den Hurk, H., Neubauer, A., Sonnemans, M. A. F., Sluijs, J. A., Köycü, S., Ramdjielal, R. D. J., Salehi, A., Martens, G. J. M., et al. (1998) · Science · doi:10.1126/science.279.5348.242 · Cited by 561
Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
Bertram, L., Blacker, D., Mullin, K., Keeney, D. B., Jones, J., Basu, S., Yhu, S., McInnis, M. G., Go, R. C. P., Vekrellis, K., et al. (2000) · Science · doi:10.1126/science.290.5500.2302 · Cited by 519
Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme
Vekrellis, K., Ye, Z., Qiu, W. Q., Walsh, D. M., Hartley, D. M., Chesneau, V., Rosner, M. R., & Selkoe, D. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01657.2000 · Cited by 498
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., & Strickland, D. K. (1995) · Cell · doi:10.1016/0092-8674(95)90320-8 · Cited by 401
Risk Estimates of Dementia by Apolipoprotein E Genotypes From a Population-Based Incidence Study: The Rotterdam Study
Slooter, A. J. C., Cruts, M., Kalmijn, S., Hofman, A., Breteler, M. M. B., Van Broeckhoven, C., & van Duijn, C. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.964 · Cited by 399 · cited 2×
“The risk attributable to the APOE∗4 allele is 20–29% (Seshadri et al. 1995; Slooter et al. 1998).”
Background
Susceptibility Locus for Alzheimer's Disease on Chromosome 10
Myers, A., Holmans, P., Marshall, H. N., Kwon, J. M., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVriéze, F. W., Crook, R., et al. (2000) · Science · doi:10.1126/science.290.5500.2304 · Cited by 385
Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings
Rocca, W. A., Albert Hofman, D., Brayne, C., Breteler, M. M. B., Clarke, M., Copeland, J. R. M., Dartigues, J., Engedal, K., Hagnell, O., Heeren, T. J., et al. (1991) · Annals of Neurology · doi:10.1002/ana.410300310 · Cited by 384
Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells
Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T., & Masaki, Τ. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9535 · Cited by 383
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Ertekin‐Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C. B., Baker, M., Adamson, J. L., Ronald, J., Blangero, J., Hutton, M. L., & Younkin, S. G. (2000) · Science · doi:10.1126/science.290.5500.2303 · Cited by 370
A full genome scan for late onset Alzheimer's disease
Kehoe, P. G. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.237 · Cited by 357
A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism
Kamboh, M. I., Sanghera, D. K., Ferrell, R. E., & DeKosky, S. T. (1995) · Nature Genetics · doi:10.1038/ng0895-486 · Cited by 336
Self-citation
APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease
Meyer, M. R., Tschanz, J. T., Norton, M. C., Welsh-Bohmer, K. A., Steffens, D. C., Wyse, B. W., & Breitner, J. C. S. (1998) · Nature Genetics · doi:10.1038/1206 · Cited by 335
Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled
Li, Y.-J., Scott, W. K., Hedges, D. J., Zhang, F., Gaskell, P. C., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339815 · Cited by 312
The Number of Trait Loci in Late-Onset Alzheimer Disease
Daw, E. W., Payami, H., Nemens, E. J., Nochlin, D., Bird, T. D., Schellenberg, G. D., & Wijsman, E. M. (2000) · The American Journal of Human Genetics · doi:10.1086/302710 · Cited by 295
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
Bullido, M. J., Artiga, M. J., Recuero, M., Sastre, I., García, M., Aldudo, J., Lendon, C. L., Han, S. W., Morris, J. C., Frank, A., et al. (1998) · Nature Genetics · doi:10.1038/ng0198-69 · Cited by 286
Replication of Linkage Studies of Complex Traits: An Examination of Variation in Location Estimates
Roberts, S. B., MacLean, C. J., Neale, M. C., Eaves, L. J., & Kendler, K. S. (1999) · The American Journal of Human Genetics · doi:10.1086/302528 · Cited by 274
Results of a high-resolution genome screen of 437 Alzheimer's Disease families
Blacker, D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg007 · Cited by 262
Alzheimer's Disease Care: Costs And Potential Savings
Leon, J., Cheng, C.-K., & Neumann, P. J. (1998) · Health Affairs · doi:10.1377/hlthaff.17.6.206 · Cited by 247
The Cholesterol Quartet
Goldstein, J. L., & Brown, M. S. (2001) · Science · doi:10.1126/science.1061815 · Cited by 241
Glutathione S-transferase omega-1 modifiesage-at-onset of Alzheimer disease and Parkinson disease
Li, Y. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg357 · Cited by 234
Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein
Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K. (1995) · Annals of Neurology · doi:10.1002/ana.410370212 · Cited by 232
Oxidized LDL Modulates Bax/Bcl-2 Through the Lectinlike Ox-LDL Receptor-1 in Vascular Smooth Muscle Cells
Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Morimoto, M., Hayashida, K., Hashimoto, N., & Kita, T. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.955 · Cited by 216
Full genome screen for Alzheimer disease: Stage II analysis*
Myers, A., DeVriéze, F. W., Holmans, P., Hamshere, M. L., Crook, R., Compton, D., Marshall, H. N., Meyer, D., Shears, S., Booth, J., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10183 · Cited by 208
Complete Genomic Screen in Late-Onset Familial Alzheimer Disease: Evidence for a New Locus on Chromosome 12
Pericak-Vance, M. A. (1997) · JAMA · doi:10.1001/jama.1997.03550150041033 · Cited by 206
Identification of Novel Genes in Late-Onset Alzheimer's Disease
Pericak‐Vance, M. A., Grubber, J. M., Bailey, L., Hedges, D. J., West, S. G., Santoro, L., Kemmerer, B., Hall, J. L., Saunders, A. M., Roses, A. D., et al. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00196-0 · Cited by 196
Association between polymorphism in regulatory region of gene encoding tumour necrosis factor α and risk of Alzheimer's disease and vascular dementia: a case-control study
McCusker, S. M., Curran, M. D., Dynan, K., McCullagh, C. D., Urquhart, D., Middleton, D., Patterson, C. C., McIlroy, S. P., & Passmore, A. P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04008-3 · Cited by 191
Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease
Okuizumi, K., Onodera, O., Namba, Y., Ikeda, K., Yamamoto, T. T., Seki, K., Ueki, A., Nanko, S., Tanaka, H., Takahashi, H., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-207 · Cited by 183
Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease: What Physicians Know, and What They Should Know
Seshadri, S. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540350068018 · Cited by 163
The Fe65 Adaptor Protein Interacts through Its PID1 Domain with the Transcription Factor CP2/LSF/LBP1
Zambrano, N., Minopoli, G., de Candia, P., & Russo, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20128 · Cited by 153
Evidence for an Alzheimer Disease Susceptibility Locus on Chromosome 12 and for Further Locus Heterogeneity
Rogaeva, E. A. (1998) · JAMA · doi:10.1001/jama.280.7.614 · Cited by 150
Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study
Lambert, J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.57 · Cited by 147
Genetic Association of a Cystatin C Gene Polymorphism With Late-Onset Alzheimer Disease
Finckh, U. (2000) · Archives of Neurology · doi:10.1001/archneur.57.11.1579 · Cited by 142
Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community
Farrer, L. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg037 · Cited by 133
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease
Lambert, J. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1511 · Cited by 132
How heritable is Alzheimer's disease late in life? Findings from Swedish twins
Pedersen, N. L., Gatz, M., Berg, S., & Johansson, B. E. A. (2003) · Annals of Neurology · doi:10.1002/ana.10999 · Cited by 131
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Farrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124
Fine Mapping of the Chromosome 12 Late-Onset Alzheimer Disease Locus: Potential Genetic and Phenotypic Heterogeneity
Scott, W. K., Grubber, J. M., Conneally, P. M., Small, G. W., Hulette, C. M., Rosenberg, C. K., Saunders, A. M., Roses, A. D., Haines, J. L., & Pericak‐Vance, M. A. (2000) · The American Journal of Human Genetics · doi:10.1086/302828 · Cited by 114
Genetic heterogeneity in catatonic schizophrenia: A family study
Beckmann, H., Franzek, E., & Stöber, G. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960531)67:3 · Cited by 110
A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer’s disease
Crawford, F., Freeman, M. J., Schinka, J. A., Abdullah, L. I., Gold, M., Hartman, R. D., Krivian, K., Morris, M. D., Richards, D., Duara, R., et al. (2000) · Neurology · doi:10.1212/wnl.55.6.763 · Cited by 109
Ordered-Subsets Linkage Analysis Detects Novel Alzheimer Disease Loci on Chromosomes 2q34 and 15q22
Scott, W. K., Hauser, E. R., Schmechel, D. E., Welsh-Bohmer, K. A., Small, G. W., Roses, A. D., Saunders, A. M., Gilbert, J. R., Vance, J. M., Haines, J. L., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/379083 · Cited by 105
Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype
Sweet, R. A., Nimgaonkar, V. L., Devlin, B., & Jeste, D. V. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001262 · Cited by 103
Genetic Studies on Chromosome 12 in Late-Onset Alzheimer Disease
Wu, W. S. (1998) · JAMA · doi:10.1001/jama.280.7.619 · Cited by 100
Genetic variants in a haplotype block spanningIDE are significantly associated with plasma A?42 levels and risk for Alzheimer disease
Ertekin‐Taner, N., Allen, M., Fadale, D. J., Scanlin, L., Younkin, L. H., Petersen, R. C., Graff‐Radford, N. R., & Younkin, S. G. (2004) · Human Mutation · doi:10.1002/humu.20016 · Cited by 99
A Genome Survey for Novel Alzheimer Disease Risk Loci: Results at 10-cM Resolution
Zubenko, G. S., Hughes, H. B., Stiffler, J. S., Hurtt, M. R., & Kaplan, B. B. (1998) · Genomics · doi:10.1006/geno.1998.5306 · Cited by 97
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer’s disease in Finland
Hiltunen, M. O., Mannermaa, A., Thompson, D., Easton, D. F., Pirskanen, M. M., Helisalmi, S., Koivisto, A. M., Lehtovirta, M., Ryynänen, M., & Soininen, H. S. (2001) · Neurology · doi:10.1212/wnl.57.9.1663 · Cited by 97
Genetic variation in a haplotype block spanningIDE influences Alzheimer disease
Prince, J. A., Feuk, L., Gu, H. F., Johansson, B. E. A., Gatz, M., Blennow, K., & Brookes, A. J. (2003) · Human Mutation · doi:10.1002/humu.10282 · Cited by 96
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
Abraham, R., Myers, A., Wavrant-DeVrièze, F., Hamshere, M. L., Thomas, H. V., Marshall, H. N., Compton, D., Spurlock, G., Turic, D., Hoogendoorn, B., et al. (2001) · Human Genetics · doi:10.1007/s00439-001-0614-1 · Cited by 95
Monogenic Dyslipidemias: Window on Determinants of Plasma Lipoprotein Metabolism
Hegele, R. A. (2001) · The American Journal of Human Genetics · doi:10.1086/324647 · Cited by 94
A Second Locus for Very-Late-Onset Alzheimer Disease: A Genome Scan Reveals Linkage to 20p and Epistasis between 20p and the Amyloid Precursor Protein Region
Olson, J. M., Goddard, K. A. B., & Dudek, D. M. (2002) · The American Journal of Human Genetics · doi:10.1086/341034 · Cited by 91
Alzheimer's disease : advances in etiology, pathogenesis, and therapeutics
Iqbal, K., Sisodia, S. S., Winblad, B. G., & Disorders, R. (2001) · Wiley eBooks · Cited by 89
No Genetic Effect of α1-Antichymotrypsin in Alzheimer Disease
Haines, J. L., Pritchard, M. L., Saunders, A. M., Schildkraut, J. M., Growdon, J. H., Gaskell, P. C., Farrer, L. A., Auerbach, S. H., Gusella, J. F., Locke, P. A., et al. (1996) · Genomics · doi:10.1006/geno.1996.0158 · Cited by 87
Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease
Payami, H., Schellenberg, G. D., Zareparsi, S., Kaye, J. A., Sexton, G. J., Head, M. A., Matsuyama, S. S., Jarvik, L. F., Miller, B. L., McManus, D. Q., et al. (1997) · Neurology · doi:10.1212/wnl.49.2.512 · Cited by 84
Molecular genetics of Alzheimerʼs disease: the role of β-amyloid and the presenilins
Tandon, A., Rogaeva, E. A., MULLAN, M. J., & George‐Hyslop, P. S. (2000) · Current Opinion in Neurology · doi:10.1097/00019052-200008000-00003 · Cited by 81
Fine mapping of the -T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
Ertekin-Taner, N. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg343 · Cited by 80
Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2
Finckh, U., van Hadeln, K., Müller‐Thomsen, T., Alberici, A., Binetti, G. G., Hock, C., Nitsch, R. M., Stoppe, G., Reiss, J., & Gal, A. (2003) · Neurogenetics · doi:10.1007/s10048-003-0157-9 · Cited by 78
The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease
Lambert, J., Goumidi, L., Vrièze, F. W., Frigard, B., Harris, J. M., Cummings, A., Coates, J., Pasquier, F., Cottel, D., Gaillac, M., et al. (2000) · Human Molecular Genetics · doi:10.1093/oxfordjournals.hmg.a018918 · Cited by 77
The Human Gene Encoding the Lectin-Type Oxidized LDL Receptor (OLR1) Is a Novel Member of the Natural Killer Gene Complex with a Unique Expression Profile
Yamanaka, S., Zhang, X., Miura, K., Kim, S., & Iwao, H. (1998) · Genomics · doi:10.1006/geno.1998.5561 · Cited by 76
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
Saunders, A. J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg310 · Cited by 72
Major Recessive Gene(s) with Considerable Residual Polygenic Effect Regulating Adult Height: Confirmation of Genomewide Scan Results for Chromosomes 6, 9, and 12
Xu, J., Bleecker, E. R., Jongepier, H., Howard, T. D., Koppelman, G. H., Postma, D. S., & Meyers, D. A. (2002) · The American Journal of Human Genetics · doi:10.1086/342216 · Cited by 69
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
Boussaha, M., Hannequin, D., Verpillat, P., Brice, A., Frébourg, T., & Campion, D. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00586-4 · Cited by 68
Molecular misreading: a new type of transcript mutation expressed during aging
van Leeuwen, F. W. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00151-2 · Cited by 68
Chromosome-12 Mapping of Late-Onset Alzheimer Disease among Caribbean Hispanics
Mayeux, R. P., Lee, J. H., Romas, S. N., Mayo, D., Santana, V., Williamson, J., Ciappa, A., Rondon, H. Z., Estevez, P., Lantigua, R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/324773 · Cited by 67
The Amyloid Precursor Protein Locus and Very-Late-Onset Alzheimer Disease
Olson, J. M., Goddard, K. A. B., & Dudek, D. M. (2001) · The American Journal of Human Genetics · doi:10.1086/323472 · Cited by 64
Alzheimer’s disease and the cystatin C gene polymorphism: an association study
Beyer, K., Lao, J. I., Gómez, M., Riutort, N., Latorre, P., Mate, J. L., & Ariza, A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02307-2 · Cited by 64
Association of the 3′ UTR transcription factor LBP‐1c/CP2/LSF polymorphism with late‐onset Alzheimer's disease
Luedecking‐Zimmer, E., DeKosky, S. T., Nebes, R. D., & Kamboh, M. I. (2002) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10026 · Cited by 63
Self-citation
Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE)
Edland, S. D., Vriesé, F. W.-D., Compton, D. M., Smith, G. E., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., & Petersen, R. C. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00488-9 · Cited by 62
Linkage analysis of Alzheimer disease with psychosis
Bacanu, S., Devlin, B., Chowdari, K. V., DeKosky, S. T., Nimgaonkar, V. L., & Sweet, R. A. (2002) · Neurology · doi:10.1212/wnl.59.1.118 · Cited by 60
Alzheimer's disease and apolipoprotein e‐4 allele in an amish population
Pericak‐Vance, M. A., Johnson, C. C., Rimmler, J. B., Saunders, A. M., Robinson, L. C., D'Hondr, E. G., Jackson, C. E., & Haines, J. L. (1996) · Annals of Neurology · doi:10.1002/ana.410390605 · Cited by 60
The α2-macroglobulin gene in AD
Koster, M. N., Dermaut, B., Cruts, M., Houwing‐Duistermaat, J. J., Roks, G., Tol, J., Ott, A., Albert Hofman, D., Munteanu, G., Breteler, M. M. B., et al. (2000) · Neurology · doi:10.1212/wnl.55.5.678 · Cited by 58
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies
Bertram, L., Blacker, D., Crystal, A., Mullin, K., Keeney, D. B., Jones, J. L., Basu, S., Yhu, S., Guénette, S. Y., McInnis, M. G., et al. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00193-5 · Cited by 58
Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics
Lee, J. H., Mayeux, R. P., Mayo, D., Mo, J., Santana, V., Williamson, J., Flaquer, A., Ciappa, A., Rondon, H. Z., Estevez, P., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001538 · Cited by 53
TNF gene polymorphism and its relation to intracerebral production of TNFα and TNFβ in AD
Tarkowski, E., Liljeroth, A., Nilsson, A. M., Ricksten, A., Davidsson, P., Minthon, L., & Blennow, K. (2000) · Neurology · doi:10.1212/wnl.54.11.2077 · Cited by 53
Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.
Song, Y.-Q., Rogaeva, E., Premkumar, S., Brindle, N., Kawarai, T., Orlacchio, A., Yu, G., Lévesque, G., Nishimura, M., Ikeda, M., et al. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00470-4 · Cited by 52
Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12
Luedecking‐Zimmer, E., DeKosky, S. T., Chen, Q., Barmada, M. M., & Kamboh, M. I. (2002) · Human Genetics · doi:10.1007/s00439-002-0802-7 · Cited by 48
Self-citation
Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer’s disease
Maruyama, H., Izumi, Y., Oda, M., Torii, T., Morino, H., Toji, H., Sasaki, K., Terasawa, H., Nakamura, S., & Kawakami, H. (2001) · Neurology · doi:10.1212/wnl.57.2.337 · Cited by 46
Association of 3′-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer’s disease
Lambert, J., Luedecking‐Zimmer, E., Merrot, S., Hayes, A., Thaker, U., Desai, P., Houzet, A., Hermant, X., Cottel, D., Pritchard, A. L., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.6.424 · Cited by 44
Self-citation
Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population
Toji, H., Maruyama, H., Sasaki, K., Nakamura, S., & Kawakami, H. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00855-6 · Cited by 44
HLA-DR antigens associated with major genetic risk for late-onset Alzheimerʼs disease
Curran, M. D., Middleton, D., Edwardson, J. A., Perry, R. H., McKeith, I. G., Morris, C. M., & Neill, D. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00028 · Cited by 43
Genetic variation in α1-antichymotrypsin and its association with Alzheimer’s disease
Wang, X., DeKosky, S. T., Luedecking‐Zimmer, E., Ganguli, M., & Kamboh, M. I. (2002) · Human Genetics · doi:10.1007/s00439-002-0697-3 · Cited by 41
Self-citation
Purification and Characterization of the Serum Amyloid A3 Enhancer Factor
Bing, Z., Reddy, S. A. G., Ren, Y., Liao, W. S. ‐., & Qin, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24649 · Cited by 40
Genetic variability at the amyloid-β precursor protein locus may contribute to the risk of late-onset Alzheimer's disease
Vrièze, F. W., Crook, R., Holmans, P., Kehoe, P. G., Owen, M. J., Williams, J. H., Roehl, K., Lahiri, D. K., Shears, S., Booth, J., et al. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00417-6 · Cited by 40
Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease
Mubumbila, V., Sutter, A., Ptok, U., Heun, R., & Quirin‐Stricker, C. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00955-2 · Cited by 40
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease
Kamboh, M. I., Aston, C. E., Perez-Tur, J., Kokmen, E., Ferrell, R. E., Hardy, J., & DeKosky, S. T. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00129-9 · Cited by 40
Self-citation
Very low density lipoprotein receptor binds apolipoprotein E2/2 as well as apolipoprotein E3/3
Takahashi, S., Oida, K., Ookubo, M., Suzuki, J., Kohno, M., Murase, T., Yamamoto, T. T., & NAKAI, T. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00439-5 · Cited by 39
The very high prevalence of AD in an Arab population is not explained by APOE ε4 allele frequency
Bowirrat, A., Friedland, R. P., Chapman, J., & Korczyn, A. D. (2000) · Neurology · doi:10.1212/wnl.55.5.731 · Cited by 38
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease
Harold, D. H., Peirce, T., Moskvina, V., Lovestone, S., Powell, J. F., Foy, C., Archer, N. J., Walter, S., Edmonson, A., McIlroy, S. P., et al. (2003) · Human Genetics · doi:10.1007/s00439-003-0960-2 · Cited by 38
Lack of association of very low density lipoprotein receptor gene polymorphism with caucasian Alzheimer's disease
Okuizumi, K., Onodera, O., Tanaka, H., Tsuji, S., Seki, K., Namba, Y., Ikeda, K., Saunders, A. M., Pericak‐Vance, M. A., & Roses, A. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400220 · Cited by 38
HLA‐A2, or a closely linked gene, confers susceptibility to early‐onset sporadic Alzheimer's disease in men
Payami, H., Kaye, J. A., Becker, W. C., Norman, D. J., & Wetzsteon, P. J. (1991) · Neurology · doi:10.1212/wnl.41.10.1544 · Cited by 34
Chromosome 12 and late-onset Alzheimer's disease
Poduslo, S. E., & Yin, X. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02130-9 · Cited by 33
Genetic association of anLBP-1c/CP2/LSFgene polymorphism with late onset Alzheimer's disease: Table 1
Taylor, A., Yip, A. G., Brayne, C., Easton, D., Evans, J. G., Xuereb, J., Cairns, N., Esiri, M. M., & Rubinsztein, D. C. (2001) · Journal of Medical Genetics · doi:10.1136/jmg.38.4.232 · Cited by 33
No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians
Pritchard, M. L., Saunders, A. M., Gaskell, P. C., Small, G. W., Conneally, P. M., Rosi, B. L., Yamaoka, L. H., Roses, A. D., Haines, J. L., & Pericak‐Vance, M. A. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12630-6 · Cited by 31
Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease
Schwarz, S., Eisele, T., Diehl, J., Müller, U., Förstl, H., Kurz, A., & Riemenschneider, M. J. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00380-x · Cited by 28
Lack of association of trinucleotide repeat polymorphisms in the very‐low‐density lipoprotein receptor gene with Alzhelner's disease
Ba, H. C., Roberts, C. T., Greenberg, S. M., Rebeck, G. W., Bs, R. C., Wallace, R. B., Jacob, H. J., & Hyman, B. T. (1996) · Annals of Neurology · doi:10.1002/ana.410390617 · Cited by 27
Genetic variation in CTNNA3 encoding alpha-3 catenin and Alzheimer's disease
Blomqvist, M. E.-L., Andreasen, N., Bogdanović, N., Blennow, K., Brookes, A. J., & Prince, J. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.032 · Cited by 27
No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population
Sakai, A., Ujike, H., Nakata, K., Takehisa, Y., Imamura, T., Uchida, N., Kanzaki, A., Yamamoto, M., Fujisawa, Y., Okumura, K., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20106 · Cited by 27
Gene expression profiles: Creating new perspectives in arthritis research
Grant, E. P., Pickard, M. D., Briskin, M., & Gutierrez-Ramos, J.-C. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10014 · Cited by 27
Lack of association between α2-macroglobulin polymorphisms and Alzheimer's disease
Wang, X., Luedecking‐Zimmer, E., Minster, R. L., Ganguli, M., DeKosky, S. T., & Kamboh, M. I. (2001) · Human Genetics · doi:10.1007/s004390000445 · Cited by 25
Self-citation
Variation in the urokinase‐plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD
Myers, A., Marshall, H. N., Holmans, P., Compton, D., Crook, R., Mander, A., Nowotny, P., Smemo, S., Dunstan, M. L., Jehu, L., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20036 · Cited by 24
Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
Majores, M., Bagli, M., Papassotiropoulos, A., Schwab, S. G., Jessen, F., Rao, M. L., Maier, W., & Heun, R. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01283-0 · Cited by 23
Computerized self‐assessment in psychiatric in‐patients: acceptability, feasibility and influence of computer attitude
Weber, B., Fritze, J., Schneider, B., Simminger, D., & Maurer, K. (1998) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1998.tb10056.x · Cited by 22
Short communication Association of the HLA-A2 allele with an earlier age of onset of Alzheimer's disease
Combarros, O., Escribano, J., Sánchez‐Velasco, P., Leyva‐Cobián, F., Oterino, A., Leno, C., & Berciano, J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb01735.x · Cited by 21
Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease
Middleton, D., Mawhinney, H., Curran, M. D., Edwardson, J. A., Perry, R., McKeith, I. G., Morris, C. M., Ince, P. G., & Neill, D. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00045-2 · Cited by 20
Genetics of type III hyperlipoproteinemia
Feussner, G., Piesch, S., Dobmeyer, J., & Fischer, C. (1997) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1997)14:3 · Cited by 18
An HLA and family study of Alzheimer's disease
Renvoize, E. B. (1984) · Psychological Medicine · doi:10.1017/s0033291700015117 · Cited by 16
No association between a previously reported OLR1 3′ UTR polymorphism and Alzheimer’s disease in a large family sample
Bertram, L., Parkinson, M., Mullin, K., Menon, R., Blacker, D., & Tanzi, R. E. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.016980 · Cited by 16
No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese
Chen, L., Baum, L., Ng, H., Chan, Y. S., Mak, Y. T., Woo, J., Chiu, H. F. K., & Pang, C. P. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00975-0 · Cited by 12
The 5-repeat allele in the very-low-density lipoprotein receptor gene polymorphism is not increased in sporadic Alzheimer's disease in Japanese
Arinami, T., Takekoshi, K., Yanagi, H., Hamamoto, M., & Hamaguchi, H. (1996) · Neurology · doi:10.1212/wnl.47.5.1349 · Cited by 11
A Genomic Search for Alzheimer's Disease Genes
Haines, J. L., Bailey, L., Grubber, J. M., Hedges, D. J., Hall, J. L., West, S. G., Santoro, L., Kemmerer, B., Saunders, A. M., Roses, A. D., et al. (2001) · doi:10.1002/0470846453.ch4 · Cited by 8
No evidence of association between the D10S1423 locus and Alzheimer disease in Brazilian patients
Nishimura, A. L., Oliveira, J. R. M., Otto, P. A., Matioli, S. R., de Brito-Marques, P. R., Bahia, V. S., Nitríni, R., & Zatz, M. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170076 · Cited by 6
No association between marker D10S1423 and Alzheimer's disease
Bertram, L., Saunders, A. J., Mullin, K., Sampson, A. J., Moscarillo, T. J., Basset, S. S., Go, R. C. P., Blacker, D., & Tanzi, R. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001355 · Cited by 2
Expression profiling and comparative sequence derived insights into lipid metabolism
Callow, M. J., & Rubin, E. M. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00009 · Cited by 2
Untitled work
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6
Untitled work
Price (1999) · doi:10.1002/1531-8249(199903)45:3

Research works printed but not linked: 4

Holmans P., 2003, Evidence of interaction between susceptibility loci on chromosomes 1, 10 and 12 in late‐onset Alzheimer's disease (LOAD), Am J Hum Genet, 73, 184
Roses A. D., 1995, Alzheimer's disease as a model of molecular gerontology, J NIH Res, 7, 51
Stanton K. C., 2003, Further evidence of linkage of Alzheimer's disease on chromosome 12, Am J Hum Genet, 73, 471
Xu P.‐T., 2002, Characterization and analyses of AD candidate genes P16 and MTAP on chromosome 9p21, Am J Hum Genet, 71, A490

Sorted by citations

Review Article: Genetics of Alzheimer Disease
Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792
Epigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 406
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., & Haynatzki, G. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.018 · Cited by 320
Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
Migliore, L., & Coppedè, F. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.10.011 · Cited by 331

See all 170

Authors: Kamboh, M. I.
Affiliations: University of Pittsburgh (US)
Corresponding author: Kamboh, M. Ilyas
ORCID: Kamboh, M. Ilyas
Venue: Annals of Human Genetics
Publisher: Wiley
Published: 2004-06-28
Volume: 68
Issue: 4
Pages: 381-404
ISSN: 0003-4800 (ISSN-L)
1469-1809
DOI: 10.1046/j.1529-8817.2004.00110.x
OpenAlex: W2137932456
Cited by: 170
References: 131
Citations by year: 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 12
FWCI: 2.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of Human Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 05-133, P50AG005133, AG13672, R01AG013672)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: late-onset Alzheimer's disease, apolipoprotein E, genetic susceptibility, genetic loci, genome-wide linkage analysis, linkage disequilibrium, complex diseases, genetic risk factors
MeSH terms: Alzheimer Disease, Apolipoproteins E, Humans, Genetic Linkage, Molecular Biology, Biomarkers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular Genetics of Late‐Onset Alzheimer's Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks