Diabetes-Haufigkeit bei Akromegalie und Cushing-Syndrom
Abstract
In a retrospective study glucose metabolism was investigated in 206 patients with acromegaly and 131 patients with Cushing's disease. 40.5% of the patients with hypersomatotropism and 32.0% of the patients with hypercortisolism suffered from overt diabetes mellitus. Impaired glucose tolerance was present prior to therapy in 28.2% and 30.6% of the patients, respectively. In acromegaly the incidence of overt diabetes mellitus was higher in women than in men, but no difference existed in the distribution of impaired glucose tolerance between both sexes. No correlation was found between growth hormone levels and occurrence of diabetes. In acromegaly and Cushing's disease overt diabetes increased with advanced age. Diabetes mellitus occurred independently from the etiology of hypercortisolism.
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Among patients with endogenous Cushing syndrome, 20% to 45% have diabetes and 10% to 30% have defective glucose tolerance, so overall prevalence of glucose metabolism impairment can approach 70%.
“From % to % of patients with endogenous CS have DM, and % to % have defective glucose tolerance, so the overall prevalence of glucose metabolism impairments can come close to %, as shown in Table (, , -).”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [182]
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Kim, H., Kang, J., Jung, D., Kang, B., Chang, D., & Yang, M. (2020) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2020.106506 · Cited by 5 · see citing works
Sun, Q., Li, X., Chen, P., et al. (2021) · International Journal of Endocrinology · doi:10.1155/2021/3666692 · Cited by 5 · see citing works
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Helm, K. D., Nass, R. M., & Evans, W. S. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00019-x · Cited by 5 · see citing works
Juszczak, A., Morris, D. G., Grossman, A. B., & Nieman, L. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00013-5 · Cited by 4 · see citing works
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Khaire, S. S., Gada, J. V., Varthakavi, P. K., et al. (2021) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2021.101394 · Cited by 2 · see citing works
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Matchekhina, L. V., Belaya, Z. E., Mel'nichenko, G. A., & Shestakova, M. V. (2015) · Terapevticheskii arkhiv · doi:10.17116/terarkh2015871098-104 · Cited by 2 · see citing works
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Dunn, L. K., & Nemergut, E. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-56691-7_3 · Cited by 2 · see citing works
Hypophysenstörungen und sekundärer Diabetes mellitus
Zimmermann, A. G., & Weber, M. (2009) · Der Diabetologe · doi:10.1007/s11428-009-0438-5 · Cited by 1 · see citing works
(2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0660-4.00024-7 · Cited by 1 · see citing works
Clinical Features of Acromegaly
Ilie, I. R. P., & Korbonits, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95964-6 · Cited by 1 · see citing works
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Yang, J. Y., Kang, M. S., Song, T. H., Jeong, I. K., Seo, P.-J., & Kim, H. J. (2006) · The Journal of Korean Diabetes Association · doi:10.4093/jkda.2006.30.6.428
Lipodystrophies induites par les glucocorticoïdes : de la physiopathologie à la prise en charge
Vatier, C., Moldes, M., & Fève, B. (2021) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2021.01.013 · Cited by 1 · see citing works
Endocrine Disorders that Cause Diabetes
Hanley, N. (2010) · doi:10.1002/9781444324808.ch17 · Cited by 5 · see citing works
Morris, D. G., Grossman, A. B., & Nieman, L. K. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00015-0
Baudry, C., Waintrop, C., & Mosnier-Pudar, H. (2011) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(11)53860-0
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Володимирівна, І. Н. (2016) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.208936
Nandhini, L. P., Kamalanathan, S., & Sahoo, J. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_6
Little, S. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-49687-2.00028-x
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Popa-Ilie, I. R., & Korbonits, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00278-8
Chasseloup, F. (2022) · theses.fr (ABES) · doi:10.70675/ddec5b6dzf376z4aadz9970zf0bf052c6f02
- Authors
- Biering, H., Knappe, G., Gerl, H., & Lochs, H.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Venue
- Acta Medica Austriaca
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 27
- Issue
- 1
- Pages
- 27-31
- ISSN
- 0303-8173 (ISSN-L)
- 1563-2571
- OpenAlex
- W2102706056
- Cited by
- 113
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Medica Austriaca (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- acromegaly, Cushing's disease, diabetes mellitus, impaired glucose tolerance, hypercortisolism, growth hormone excess, sex differences, age as risk factor, glucose metabolism
- MeSH terms
- Acromegaly, Adult, Age Factors, Aged, Cushing Syndrome, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Retrospective Studies, Prevalence, Diabetes Complications
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