Cited by 193Pituitary Gland Disorders and TreatmentsAdrenal Hormones and DisordersPancreatic function and diabetes

Diabetes in Cushing syndrome: basic and clinical aspects

Mazziotti, Gherardo, Gazzaruso, Carmine, Giustina, Andrea·2011·Trends in Endocrinology & Metabolism

Abstract

Diabetes mellitus is a frequent complication of Cushing syndrome (CS) which is caused by chronic exposure to glucocorticoid excess, either endogenous or exogenous, and that is characterized by several clinical symptoms such as central obesity, purple striae, proximal muscle weakness, acne, hirsutism and neuropsychological disturbances. Diabetes occurs as a consequence of an insulin-resistant state together with impaired insulin secretion which are induced by glucocorticoid excess. The management of patients with CS and diabetes mellitus includes the treatment of hyperglycemia and, when possible, the correction of glucocorticoid excess. This review focuses on the disorders of glucose metabolism in patients exposed to glucocorticoid excess, addressing both the pathophysiological aspects and the clinical and therapeutic implications.

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Registry

Crossref · 10.1016/j.tem.2011.09.001

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74 of 74 references verified0 citation errors · 0 not checkable

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  • Chronic cortisol excess (hypercortisolism) is commonly associated with impaired glucose metabolism and the development of secondary type 2 diabetes.

    “with chronic CORT excess (hypercortisolism) commonly associated with the impairment of glucose metabolism and the development of secondary type 2 diabetes ( 3, 4 ).”
  • Controlling hypercortisolism is the first step toward improving glucose metabolism in endogenous Cushing syndrome, but different treatments may affect diabetes outcome regardless of how well cortisol excess is corrected.

    “Controlling hypercortisolism is the first step toward improving glucose metabolism in patients with endogenous CS, but different treatments for hypercortisolism may affect the outcome of diabetes, regardless of how well cortisol excess is corrected (, , , , , , ).”

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Authors
Mazziotti, G., Gazzaruso, C., & Giustina, A.
Affiliations
  • Azienda Ospedaliera Carlo Poma (IT)
  • IRCCS Policlinico San Donato (IT)
  • University of Brescia (IT)
Corresponding author
Giustina, Andrea
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2011-12
Volume
22
Issue
12
Pages
499-506
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2023367357
Cited by
193
References
76
Citations by year
2026: 5 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 15 · 2021: 16 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 13 · 2015: 20 · 2014: 11 · 2013: 23 · 2012: 11
FWCI
2.01
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
Cushing's syndrome, diabetes mellitus, glucocorticoid excess, insulin resistance, impaired insulin secretion, glucose metabolism disorders, hyperglycemia, pathophysiology
MeSH terms
Animals, Cushing Syndrome, Humans, Hyperglycemia, Severity of Illness Index, Diabetes Complications

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