Linum usitatissimum Delivery over Chitosan Nanobiopolymer: Enhanced Effects on Polycystic Ovary Syndrome Condition
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L.) extract (FSE). The number of main features and bio-interface properties of CHIT-FSE were determined by SEM, DLS, FTIR, XRD, TGA, and zeta potential analyses and compared to those of chitosan lacking FSE. A GC-MS analysis was also conducted to reveal the bioactive compounds of FSE. The active anchoring of the FSE phytomolecules over chitosan nanoparticles with enhanced thermal and structural stability was correspondingly verified. Subsequently, the influence of CHIT-FSE, CHIT-TPP, and FSE supplementation was assessed on hormonal and biochemical markers of polycystic ovary syndrome (PCOS) in female rats and compared with untreated and healthy control groups. After 16 days of treatment, CHIT-FSE represented the best performance for controlling the serum levels of the studied biochemical (lipid profile and blood glucose level) and hormonal (insulin, testosterone, luteinizing, and follicle-stimulating hormone) parameters. Considering the negligible therapeutic activity of CHIT-TPP, the enhanced activity of CHIT-FSE compared to only FSE was expounded based on the potent action of chitosan nanoparticles in enhanced stabilization, bioavailability, transport, and permeability of the therapeutically important phytomolecules. As per the results of this investigation, supporting medically important biomolecules over chitosan can enhance their therapeutic effectiveness in controlling PCOS.
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The extent of the effect of ecdysteroids on plasma testosterone levels depends on dose, bioavailability, individual microbiome composition and genetic factors, making it difficult to draw uniform conclusions about the overall effect on plasma testosterone levels.
“It is known from the literature data that the extent of the effect of ecdysteroids on plasma testosterone levels depends on dose, bioavailability, individual microbiome composition and genetic factors, making it difficult to draw uniform conclusions about the overall effect on plasma testosterone levels [49,50].”
From Prevention of Diet-Induced Obesity by Phytoecdysteroids 20-Hydroxyecdysone and Calonysterone—Unexpected Modulation of Androgen Balance in Normal and Obese Rats (2026) · cites this paper as [49]
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- Authors
- Bayrami, A., Sojoudi, M., Rahim Pouran, S., Habibi-Yangjeh, A., & Sojoudi, S.
- Affiliations
- University of Mohaghegh Ardabili (IR)
- Corresponding author
- Bayrami, Abolfazl
- Venue
- IET Nanobiotechnology
- Published
- 2024-01
- Volume
- 2024
- Issue
- 1
- Pages
- 6693566-6693566
- ISSN
- 1751-8741 (ISSN-L)
- 1751-875X
- PMC
- PMC11268972
- OpenAlex
- W4400737063
- Cited by
- 5
- References
- 71
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- IET Nanobiotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Mohaghegh Ardabili
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- polycystic ovary syndrome, chitosan nanoparticles, flaxseed extract, flax, drug delivery, bioavailability enhancement, lipid profile, blood glucose, reproductive hormones, testosterone, insulin, follicle-stimulating hormone, luteinizing hormone
- MeSH terms
- Animals, Female, Plant Extracts, Polycystic Ovary Syndrome, Rats, Wistar, Flax, Chitosan, Rats, Nanoparticles
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