The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial
Open accessAbstract
INTRODUCTION: ) alone and in combination with clomiphene citrate (CC) compared to CC on the treatment of polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: = 20) and group 3 (n = 20) received herbal mixture capsules 700 mg/day and the herbal mixture along with CC for 3 months, respectively. Finally, several related parameters were measured, including the level of sex steroids, homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile (primary outcomes), thyroid hormones, and clinical features. The analysis was based on intention-to-treat analysis. RESULTS: No statistically significant differences were observed between the groups in terms of socio-demographic characteristics. However, after adjustment for baseline, luteinizing hormone (aMD = 4.9; 95% CI: 3.7-6.2), luteinizing hormone/follicle-stimulating hormone (aMD = 0.9; 95% CI: 0.7-1.2), total testosterone (aMD = -0.12; 95% CI: -0.2 to -0.01) in group 2 and free testosterone (aMD = -6.0; 95% CI: -9.7 to -2.3) in group 3 revealed a significant difference compared to group 1. In addition, HOMA-IR in group 2 (aMD = -1.3; 95% CI: -2.4 to -0.2) decreased significantly compared to group 1. Further, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol decreased significantly in group 2 (aMD = -21.8; 95% CI: -31.5 to -12.1; aMD = -29.9; 95% CI: -47.9 to -12.0; aMD = -21.2; 95% CI: -31.3 to -11.1; aMD = -5.1; 95% CI: -7.5 to -2.7) and group 3 (aMD = -18.3; 95% CI: -27.4 to -9.2; aMD = -26.9; 95% CI: -43.8 to -9.9; aMD = -21.4; 95% CI: -31.1 to -11.7; aMD = -5.9; 95% CI: -8.3 to -3.6) compared to group 1, respectively. However, high-density lipoproteins cholesterol in group 2 (aMD = 6.8; 95% CI: 2.9-10.7) and group 3 (aMD = 10.7; 95% CI: 7.2-14.7) increased remarkably compared to group 1. Overall, clinical outcomes improved significantly in all groups (p < 0.05). CONCLUSIONS: In general, the herbal mixture along with CC was found to improve free testosterone, HOMA-IR, lipid profile, and clinical features of PCOS women.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a study of 60 women, after three menstrual cycles, those who took an herbal mixture (spearmint, ginger, cinnamon, citrus) with or without CC exhibited substantial improvement in serum antioxidant concentrations, HOMA-IR, fasting blood glucose, and insulin levels compared to CC alone.
“After three menstrual cycles, the women who took the herbal mixture with or without the use of CC exhibited a substantial improvement in serum antioxidant concentrations, insulin resistance (HOMA-IR), fasting blood glucose, and insulin levels in relation to the group that used CC only.”
From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [207]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
Association between insulin resistance and the development of cardiovascular disease
Ormazábal, V., Nair, S., Elfeky, O. W. M., Aguayo, C. R., Salomón, C., & Zuñiga, F. A. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0762-4 · Cited by 2,344 · see citing works
Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor
LeRoith, D., Werner, H., Beitner‐Johnson, D., & Roberts, C. T. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-143 · Cited by 1,424 · see citing works
Cinnamon improves glucose and lipids of people with type 2 diabetes
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3215 · Cited by 981 · see citing works
NESTLER, J. E., POWERS, L. P., MATT, D. W., STEINGOLD, K. A., PLYMATE, S. R., RITTMASTER, R. S., CLORE, J. N., & BLACKARD, W. G. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-83 · Cited by 815 · see citing works
Franks, S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.1.89 · Cited by 802 · see citing works
Treatment options for polycystic ovary syndrome
Badawy, A., & Elnashar (2011) · International Journal of Women s Health · doi:10.2147/ijwh.s11304 · Cited by 613 · see citing works
Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W., & Graves, D. J. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034916b · Cited by 561 · see citing works
Al-Amin, Z. M., Thomson, M., Al‐Qattan, K. K., Peltonen‐Shalaby, R., & Ali, M. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061849 · Cited by 420 · see citing works
Insulin and hyperandrogenism in women with polycystic ovary syndrome
Baptiste, C. G., Battista, M., Trottier, A., & Baillargeon, J. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.010 · Cited by 368 · see citing works
Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy
Sharifi‐Rad, M., Varoni, E. M., Salehi, B., Sharifi‐Rad, J., Matthews, K. R., Ayatollahi, S. A., Kobarfard, F., Ibrahim, S. A., Mnayer, D., Zakaria, Z. A., et al. (2017) · Molecules · doi:10.3390/molecules22122145 · Cited by 345 · see citing works
Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
Gilling‐Smith, C., Story, H., Rogers, V., & Franks, S. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2321049.x · Cited by 301 · cited 1× · see citing works
“Similarly, the excessive secretion of LH and GnRH stimulates the ovarian theca cells in order to produce androgens [62].”
BackgroundEffects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome
Leo, V. D., Marca, A. L., Ditto, A., Morgante, G., & Cianci, A. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00208-3 · Cited by 266 · see citing works
Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle
Dupont, J., & Scaramuzzi, R. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160124 · Cited by 233 · see citing works
Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells
Rhode, J. M., Fogoros, S. K., Zick, S. M., Wahl, H. N., Griffith, K. A., Huang, J. T., & Liu, J. R. (2007) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-7-44 · Cited by 214 · see citing works
Lee, S., Cekanova, M., & Baek, S. J. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20374 · Cited by 211 · see citing works
Wang, J. G., Anderson, R. A., Graham, G. M., Chu, M. C., Sauer, M. V., Guarnaccia, M. M., & Løbo, R. A. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.082 · Cited by 177 · see citing works
Afshari, A. T., Shirpoor, A., Farshid, A.-A., Saadatian, R., Rasmi, Y., Saboory, E., Ilkhanizadeh, B., & Allameh, A. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.01.013 · Cited by 171 · see citing works
Cheng, D. M., Kuhn, P. E., Poulev, A., Rojo, L. E., Lila, M. A., & Raskin, I. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.06.117 · Cited by 160 · see citing works
The islet β-cell: fuel responsive and vulnerable
Nolan, C. J., & Prentki, M. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.006 · Cited by 154 · see citing works
Li, R., Theriault, A., Au, K. K. W., Douglas, T. D., Casaschi, A., Kurowska, E. M., & Mukherjee, R. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.01.023 · Cited by 152 · see citing works
Ahmed, O. M., Hassan, M. A., El-Twab, S. M. A., & Azeem, M. N. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.094 · Cited by 152 · see citing works
Regulation of Gonadotropin Secretion: Implications for Polycystic Ovary Syndrome
McCartney, C. R., Eagleson, C. A., & Marshall, J. C. (2002) · Seminars in Reproductive Medicine · doi:10.1055/s-2002-36706 · Cited by 134 · see citing works
Li, Y., Kandhare, A. D., Mukherjee-Kandhare, A. A., & Bodhankar, S. L. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.04.001 · Cited by 129 · see citing works
Grant, P. S. (2009) · Phytotherapy Research · doi:10.1002/ptr.2900 · Cited by 127 · see citing works
Ahmed, O. M., Abdel‐Moneim, A., Yazid, I. A., & Mahmoud, A. M. (2010) · Diabetologia Croatica · Cited by 123 · see citing works
Kort, D. H., & Lobo, R. A. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.05.009 · Cited by 111 · see citing works
The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats
Khaki, A., Khaki, A., Hajhosseini, L., Golzar, F., & Ainehchi, N. (2014) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v11i4.1 · Cited by 104 · see citing works
Self-citationClomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome
Brown, J., & Farquhar, C. M. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002249.pub5 · Cited by 103 · see citing works
Nutrition, insulin and polycystic ovary syndrome
Franks, S. (1996) · Reviews of Reproduction · doi:10.1530/ror.0.0010047 · Cited by 98 · see citing works
Azhary, J. M. K., Harada, M., Takahashi, N., Nose, E., Kunitomi, C., Koike, H., Hirata, T., Hirota, Y., Koga, K., Wada‐Hiraike, O., et al. (2018) · Endocrinology · doi:10.1210/en.2018-00675 · Cited by 81 · see citing works
Franks, S. (2005) · Medicine · doi:10.1383/medc.2005.33.11.38 · Cited by 78 · see citing works
Jafarnejad, S., Keshavarz, S. A., Mahbubi, S., Saremi, S., Arab, A., Abbasi, S., & Djafarian, K. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.12.006 · Cited by 75 · see citing works
Hosseini, E., Shahhoseini, M., Afsharian, P., Karimian, L., Ashrafi, M., Mehraein, F., & Afatoonian, R. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.86060 · Cited by 75 · see citing works
Abasian, Z., Rostamzadeh, A., Mohammadi, M., Hosseini, M., & Rafieian‐Kopaei, M. (2018) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2018.04.005 · Cited by 72 · see citing works
Shokoohi, M., Madarek, E. O. S., Khaki, A., Shoorei, H., Khaki, A. A., Soltani, M., & Ainehchi, N. (2018) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2018.82 · Cited by 67 · see citing works
Self-citationHöferl, M., Стоилова, И., Wanner, J., Schmidt, E., Jirovetz, L., Trifonova, D., Stanchev, V., & Krastanov, A. I. (2015) · Natural Product Communications · doi:10.1177/1934578x1501000672 · Cited by 62 · see citing works
Lipids in polycystic ovary syndrome: Role of hyperinsulinemia and effects of metformin
Banaszewska, B., Dulęba, A. J., Spaczyński, R., & Pawelczyk, L. A. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.11.009 · Cited by 59 · see citing works
Ranasinghe, P., Galappaththy, P., Constantine, G. R., Jayawardena, R., Weeratunga, H. D., Premakumara, S., & Katulanda, P. (2017) · Trials · doi:10.1186/s13063-017-2192-0 · Cited by 57 · see citing works
Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis
Constantin, R. P., Constantin, R. P., Bracht, A., Yamamoto, N. S., Ishii‐Iwamoto, E. L., & Constantin, J. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.11.003 · Cited by 55 · see citing works
Lewandowski, K. C., Skowrońska‐Jóźwiak, E., Łukasiak, K., Gałuszko, K., Dukowicz, A., Cedro, M., & Lewiñski, A. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.82672 · Cited by 55 · see citing works
Quantitative assessment of nutrition in patients with polycystic ovary syndrome (PCOS)
Szczuko, M., Skowronek, M., Zapałowska-Chwyć, M., & Starczewski, A. (2016) · PubMed · Cited by 53 · see citing works
Khodaeifar, F., Fazljou, S. M. B., Khaki, A., Torbati, M., Madarek, E. O. S., Khaki, A. A., Shokoohi, M., & Dalili, A. H. (2018) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2019.15 · Cited by 47 · see citing works
Self-citationPolycystic ovarian syndrome: the correlation between the LH/FSH ratioand disease manifestations
Alnakash, A. H. (2007) · TSpace (University of Toronto) · Cited by 44 · see citing works
Oben, J. E., Enonchong, E., Kothari, S. C., Chambliss, W. G., Garrison, R., & Dolnick, D. (2009) · Nutrition Journal · doi:10.1186/1475-2891-8-38 · Cited by 43 · see citing works
Abtahi‐Eivary, S., Moghimian, M., Soltani, M., Shoorei, H., Asghari, R., Hajizadeh, H., Shokoohi, M., Alami, S., & Ghaderi, F. K. (2017) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2018.46 · Cited by 42 · see citing works
Self-citationGinger (zingiber officinale) might improve female fertility: A rat model
Yιlmaz, N., Seven, B., Tımur, H., Yorgancı, A., İnal, H. A., Kalem, M. N., Kalem, Z., Han, Ö., & Bilezikçi, B. (2018) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2017.12.009 · Cited by 41 · see citing works
Antihyperlipidemic effects of Citrus sinensis, Citrus paradisi, and their combinations
Khan, R. A., & Mallick, N. (2015) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.171727 · Cited by 40 · see citing works
Atashpour, S., Jahromi, H. K., Jahromi, Z. K., & Maleknasab, M. (2017) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.15.9.561 · Cited by 40 · see citing works
Bayani, M., Ahmadi‐hamedani, M., & Javan, A. J. (2017) · PubMed · Cited by 37 · see citing works
Matiz, G. E., Osorio, M. R. Z., Camacho, F., Atencia, M., & Herazo, J. (2011) · Biomédica · doi:10.7705/biomedica.v32i1.614 · Cited by 37 · see citing works
Kazeem, M. I., Akanji, M. A., & Yakubu, M. T. (2015) · Pathophysiology · doi:10.1016/j.pathophys.2015.08.004 · Cited by 32 · see citing works
İmga, N. N., Karcı, A. Ç., Öztaş, D., Berker, D. S., & Güler, S. (2018) · Archives of Medical Science · doi:10.5114/aoms.2018.75864 · Cited by 31 · see citing works
The evaluation of temperament and quality of life in patients with polycystic ovary syndrome
Dağ, Z. Ö., Alpua, M., Işık, Y., Buturak, Ş. V., Tulmaç, Ö. B., & Türkel, Y. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1254610 · Cited by 29 · see citing works
Rosencrantz, M. A., Coffler, M. S., Haggan, A., Duke, K. B., Donohue, M., Shayya, R. F., Su, H.-C. I., & Chang, R. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2200 · Cited by 28 · see citing works
Metabolic Syndrome and Infertility in Women
AlAwlaqi, A., Alkhayat, K., & Hammadeh, M. E. (2016) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2016.23 · Cited by 24 · see citing works
Self-citationBehnoud, N., Farzaneh, F., & Ershadi, S. (2019) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 21 · see citing works
Metformin-clomiphene citrate vs. clomiphene citrate alone: Polycystic ovarian syndrome
Farooq, M., Ayaz, A., & Alwan, Y. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.112372 · Cited by 16 · see citing works
Tayyar, A. T., & Kahraman, S. (2018) · Archives of Medical Science · doi:10.5114/aoms.2017.72408 · Cited by 16 · see citing works
Matiz, G. E., Osorio, M. R. Z., Camacho, F., Atencia, M., & Herazo, J. (2012) · PubMed · doi:10.1590/s0120-41572012000100014 · Cited by 11 · see citing works
Evaluation of a new fully automated one-step C-peptide chemiluminescence assay (LIAISON C-Peptid).
Pfützner, A., Löbig, M., Fortunato, A., & Forst, T. M. (2003) · PubMed · Cited by 8 · see citing works
Jiang, D., Zhang, Y., Wu, X., Wang, Y., Fan, Q., & Wu, S. (2017) · PubMed · doi:10.13703/j.0255-2930.2017.10.008 · Cited by 7 · see citing works
Ghomian, N., Khadem, N., Moeindarbari, S., & Abdolrazagh, A. (2018) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2019.31 · Cited by 6 · see citing works
Herbal Medicine and Sexual Behavior in Diabetic Patients
Khaki, A., & Ainehchi, N. (2017) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2017.01 · Cited by 6 · see citing works
Self-citationThe Effects of Zingiber officinal R. on Primary Dysmenorrhea
Rahnama, P., Huseini, H. F., Mohammadi, H., Maryam, M., Shojaee, K. K., Askari, M., & Mozayani, P. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 6 · see citing works
Pournaderi, P. S., Hejazi, S. H., Yaghmaei, P., Khodaei, H., & Noormohammadi, Z. (2018) · Advanced herbal medicine · Cited by 4 · see citing works
Endothelium-dependent relaxation induced by etomidate in the aortas of insulin-resistant rats
Xue, W., Li, Y., Li, J., Li, Y., & Yang, F. (2018) · Archives of Medical Science · doi:10.5114/aoms.2018.77256 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Peng, F., Hu, Y., Peng, S., Zeng, N., & Shi, L. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2034933 · Cited by 60 · see citing works
The last update on polycystic ovary syndrome(PCOS), diagnosis criteria, and novel treatment
Ghafari, A., Maftoohi, M., Samarin, M. E., Barani, S., Banimohammad, M., & Samie, R. (2025) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2025.100228 · Cited by 58 · see citing works
Soltani, M., Moghimian, M., Abtahi-Evari, S.-H., Esmaeili, S., Mahdipour, R., & Shokoohi, M. (2023) · PubMed Central · doi:10.22074/ijfs.2022.543640.1260 · Cited by 30 · see citing works
Self-citationLan, H., Dong, Z., Zhang, M., Li, W., Chong, C., Wu, Y., Wang, Z., Liu, J., Liu, Z., Qin, X., et al. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.3973 · Cited by 28 · see citing works
Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works
Herbal therapeutics for female infertility: A systematic review and meta-analysis
Hyun, J.-Y., Jung, H.-S., & Park, J.-Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117258 · Cited by 23 · see citing works
Ainehchi, N., Farshbaf‐Khalili, A., Ghasemzadeh, A., Hamdi, K., Khaki, A., Ouladsahebmadarek, E., Delazar, A., Bakhtyari, F., & Mazandarani, M. (2019) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2019.72 · Cited by 20 · see citing works
Self-citationCui, D., Xu, Z., Qiu, S., & Sun, Y. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14462 · Cited by 15 · see citing works
Masood, I., Noreen, S., Raza, K., Khalid, W., Rahim, M. A., & Mohamedahmed, K. A. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2275528 · Cited by 11 · see citing works
Borhani, G., Mazandarani, M., & Abbaspour, H. (2024) · Crescent Journal of Medical and Biological Sciences · doi:10.34172/cjmb.2024.3012 · Cited by 10 · see citing works
Zhang, X., Ji, D., Zhang, Y., Du, C., Liang, L., Ahmad, A., Feng, Y.-H., & Ye, G. (2025) · Gynecological Endocrinology · doi:10.1080/09513590.2025.2462068 · Cited by 10 · see citing works
Gadhave, P. V., Sutar, G., Sajane, S. J., Redasani, V. K., Das, K., Dharani Prasad, P., Alobid, S. E., Almoteer, A. I., Rabbani, S. I., Yasmin, F., et al. (2024) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2024.101953 · Cited by 9 · see citing works
Habiburrahman, M., Wardoyo, M. P., Putra, A. B., Surya, I. U., & Pratama, G. (2023) · Obesity Medicine · doi:10.1016/j.obmed.2023.100490 · Cited by 8 · see citing works
Xuan, F., Ren, Y., Lu, J., Zhou, W., Jin, R., Chen, A., & Ye, Y. (2024) · Molecular Reproduction and Development · doi:10.1002/mrd.23741 · Cited by 6 · see citing works
Phytotherapy in Polycystic Ovary Syndrome (PCOS) Management: A Systematic Review
Mohamed, S. S., Allam, A. T., Elalfy, A., El‐Shiekh, R. A., Reda, A. M., & Hafeez, M. S. A. E. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500982 · Cited by 6 · see citing works
Bayrami, A., Sojoudi, M., Rahim Pouran, S., Habibi-Yangjeh, A., & Sojoudi, S. (2024) · IET Nanobiotechnology · doi:10.1049/2024/6693566 · Cited by 5 · see citing works
Rani, R., Sharma, A., & Chitme, H. R. (2023) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.1177/11795514231203864 · Cited by 4 · see citing works
Ildarabadi, A., Dastjerdi, M. V., Ghorbanpour, M., Mousavi, A., Meshkani, M., Yekaninejad, M. S., & Saedisomeolia, A. (2024) · Osong Public Health and Research Perspectives · doi:10.24171/j.phrp.2024.0187 · Cited by 4 · see citing works
Çelik, Z. M., Kurnaz, D., Özcan, A., Keskin, E., Unlugedik, E., & Aktaç, Ş. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70307 · Cited by 6 · see citing works
Devi, M. S., Chokkalingam, P., Hari, R., & Muralidharan, P. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100256 · Cited by 3 · see citing works
Cao, Q., Liu, D., Zhu, H., Wang, Q., Tan, J., Huang, X., Li, Y., Wang, R., Zhou, R., & Huang, W. (2025) · Gynecological Endocrinology · doi:10.1080/09513590.2025.2530566 · Cited by 2 · see citing works
Liang, C., Zhong, W.-P., Chen, S. X., Chen, Y., Shi, Q., She, J.-Y., Zhou, K.-D., Song, F.-L., Chu, T., Xia, Y., et al. (2025) · World Journal of Traditional Chinese Medicine · doi:10.4103/wjtcm.wjtcm_14_25 · Cited by 1 · see citing works
Dehghani, F., Arefnezhad, R., Tanideh, N., Karimi, F., Aliakbari, F., Mohseni, G., & Esmaeilpour, T. (2025) · Zygote · doi:10.1017/s0967199425100142 · Cited by 1 · see citing works
Gashti, N. G., Hajizadeh, K., Farshbaf‐Khalili, A., Mahdipour, M., & Shahnazi, M. (2025) · International Journal for Vitamin and Nutrition Research · doi:10.31083/ijvnr38965 · Cited by 1 · see citing works
Self-citationXia, L., Tian, L., Tan, J., Zhang, S., & Wu, Q. (2021) · Archives of Medical Science · doi:10.5114/aoms/133574
Ezugwu, E. E., Ugwu, A. C., Manafa, P. O., & Ezugwu, G. I. (2022) · International Journal of Advances in Medicine · doi:10.18203/2349-3933.ijam20221345
Varghese, V., Ayyappan, J. P., & Vankudre, G. S. (2025) · Springer eBooks · doi:10.1007/978-981-96-2120-0_2
Sharmin, P., Nessa, A., Ghosh, A., Jahan, L., Khatun, M. S., & Ishrat, S. (2026) · Middle East Fertility Society Journal · doi:10.1186/s43043-026-00312-6
Heidari, Z., Moradi, L., Farhangiyan, Z., Zakerkish, M., & Mansoori, A. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107316
Mohammadian, S., & Bagheri, R. B. (2025) · International Journal of Drug Research in Clinics · doi:10.34172/ijdrc.2025.e24
Raees, S., Imran, A., Hayat, Z., Malik, A., Naz, J., & Gul, M. (2026) · Research Square · doi:10.21203/rs.3.rs-10774206/v1
- Authors
- Ainehchi, N., Khaki, A., Ouladsahebmadarek, E., Hammadeh, M., Farzadi, L., Farshbaf-Khalili, A., Asnaashari, S., Khamnei, H., Khaki, A. A., & Shokoohi, M.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Saarland University (DE)
- University of Tabriz (IR)
- Corresponding author
- Ouladsahebmadarek, Elaheh
- ORCID
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2020
- Volume
- 16
- Issue
- 6
- Pages
- 1304-1318
- ISSN
- 1734-1922 (ISSN-L)
- PMC
- PMC7667414
- OpenAlex
- W3007882296
- Cited by
- 31
- References
- 68
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 1 · 2019: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Iran National Science Foundation
- Ministry of Health and Medical Education
- Tabriz University of Medical Sciences (5.4.9505)
- University of Tabriz
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- clomiphene citrate, herbal medicine, polycystic ovary syndrome, female infertility, insulin resistance, HOMA-IR, lipid profile, sex hormones, luteinizing hormone, follicle-stimulating hormone, free testosterone, thyroid hormones, combination therapy, ovulation induction, herbal medicine safety and efficacy, adverse effects, cost-effectiveness, quality of life
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
