Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
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Background Anthocyanins have been shown to exert benefits on the lipid profile in many animal models. Whether these molecules have similar beneficial effects in humans is currently unknown.Objective The objective was to investigate the effects of berry-derived anthocyanin supplements on the serum lipid profile in dyslipidemic patients.Design A total of 120 dyslipidemic subjects (age 40-65 y) were given 160 mg anthocyanins twice daily or placebo for 12 wk in a double-blind, randomized, placebo-controlled trial.Results Anthocyanin consumption increased HDL-cholesterol concentrations (13.7% and 2.8% in the anthocyanin and placebo groups, respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6% and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001). Cellular cholesterol efflux to serum increased more in the anthocyanin group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001). Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3%, respectively, in the anthocyanin group and -3.5% and 1.1%, respectively, in the placebo group; P < 0.001). In the anthocyanin group, the change in HDL cholesterol was negatively correlated with the change in CETP activity (r(s) = -0.330). The change in LDL cholesterol was positively correlated with the change in CETP mass (r(s) = 0.354). The change in cellular cholesterol efflux to serum was positively correlated with the change in HDL cholesterol (r(s) = 0.485). In vitro, cyanidin 3-O-beta-glucosides dose-dependently lowered CETP activity in human HepG2 cells.Conclusions Anthocyanin supplementation in humans improves LDL- and HDL-cholesterol concentrations and enhances cellular cholesterol efflux to serum. These benefits may be due to the inhibition of CETP.
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Some clinical studies have found antidiabetic and antihyperlipidemic effects of encapsulated berry supplements.
“Since some clinical studies have also found antidiabetic and antihyperlipidemic effects of encapsulated berry supplements, these forms may be suitable for the management of specific metabolic conditions.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [50]
Cites
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448 · see citing works
New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport
Lewis, G. F., & Rader, D. J. (2005) · Circulation Research · doi:10.1161/01.res.0000170946.56981.5c · Cited by 1,087 · see citing works
Fruit and vegetable intake and risk of cardiovascular disease: The women’s health study
Liu, S., Manson, J. E., Lee, I.-M., Cole, S. R., Hennekens, C. H., Willett, W. C., & Buring, J. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.922 · Cited by 917 · see citing works
Assmann, G., & Schulte, H. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90550-i · Cited by 872 · see citing works
Inazu, A., Brown, M. L., Hesler, C. B., Agellon, L. B., Koizumi, J., Takata, K., Maruhama, Y., Mabuchi, H., & Tall, A. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231803 · Cited by 862 · see citing works
Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol
Brousseau, M. E., Schaefer, E. J., Wolfe, M. L., Bloedon, L. T., Digenio, A. G., Clark, R. W., Mancuso, J. P., & Rader, D. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031766 · Cited by 774 · see citing works
High Density Lipoproteins and Arteriosclerosis
von Eckardstein, A., Nofer, J., & Assmann, G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.1.13 · Cited by 696 · see citing works
HDL Cholesterol and Protective Factors in Atherosclerosis
Assmann, G., & Gotto, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000131512.50667.46 · Cited by 630 · see citing works
The bioavailability and absorption of anthocyanins: Towards a better understanding
McGhie, T. K., & Walton, M. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700092 · Cited by 606 · see citing works
Antioxidant Activity of Dietary Fruits, Vegetables, and Commercial Frozen Fruit Pulps
Hassimotto, N. M. A., Genovese, M. I., & Lajolo, F. M. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf047894h · Cited by 523 · see citing works
Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol
Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., & Jula, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.323 · Cited by 445 · see citing works
Karlsen, A. S., Retterstøl, L., Laake, P., Paur, I., Kjølsrud-Bøhn, S., Sandvik, L., & Blomhoff, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1951 · Cited by 389 · see citing works
Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., & Fernández, M. L. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1911 · Cited by 376 · see citing works
Anthocyanins as Antioxidants on Human Low-Density Lipoprotein and Lecithin−Liposome Systems
Satué-Gracia, M. T., Heinonen, M., & Frankel, E. N. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf970234a · Cited by 368 · see citing works
Mozaffarian, D., Kumanyika, S., Lemaître, R. N., Olson, J. L., Burke, G. L., & Siscovick, D. S. (2003) · JAMA · doi:10.1001/jama.289.13.1659 · Cited by 289 · see citing works
Ling, W. H., Cheng, Q. X., Ma, J., & Wang, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1421 · Cited by 237 · see citing works
Xia, X., Ling, W., Ma, J., Xia, M., Hou, M., Wang, Q., Zhu, H., & Tang, Z. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2220 · Cited by 232 · see citing works
Nöthlings, U., Schulze, M. B., Weikert, C., Boeing, H., van der Schouw, Y. T., Bamia, C., Benetou, V., Λάγιου, Π., Krogh, V., Beulens, J. W. J., et al. (2008) · Journal of Nutrition · doi:10.1093/jn/138.4.775 · Cited by 226 · see citing works
Xu, J.-W., Ikeda, K., & Yamori, Y. (2004) · Hypertension · doi:10.1161/01.hyp.0000135868.38343.c6 · Cited by 197 · see citing works
Xia, M., Ling, W. H., Ma, J., Kitts, D. D., & Zawistowski, J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.3.744 · Cited by 157 · see citing works
Brown, B. G., Stukovsky, K. H., & Zhao, X.-Q. (2006) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32800ff750 · Cited by 155 · see citing works
Hansen, A. S., Marckmann, P., Dragsted, L. O., Nielsen, I. L. F., Nielsen, S. E., & Grønbæk, M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602107 · Cited by 153 · see citing works
Toshihide, N., & Yasuo, A. (1977) · Clinica Chimica Acta · doi:10.1016/0009-8981(77)90355-2 · Cited by 151 · see citing works
Anthocyanins Induce Cholesterol Efflux from Mouse Peritoneal Macrophages
Xia, M., Hou, M., Zhu, H., Ma, J., Tang, Z., Wang, Q., Li, Y., Chi, D.-S., Yu, X., Zhao, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505047200 · Cited by 147 · see citing works
Tsuda, T., Horio, F., Kitoh, J., & Osawa, T. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1311 · Cited by 145 · see citing works
Illuminating HDL — Is It Still a Viable Therapeutic Target?
Rader, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejme0707210 · Cited by 119 · see citing works
Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non‐HDL to HDL cholesterol
Lam, C. K., Zhang, Z., Yu, H., Tsang, S. Y., Huang, Y., & Chen, Z. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700319 · Cited by 84 · see citing works
Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1
Beulens, J. W. J., Sierksma, A., van Tol, A., Fournier, N., van Gent, T., Paul, J. L., & Hendriks, H. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400109-jlr200 · Cited by 77 · see citing works
Fournier, N., Francone, O. L., Rothblat, G. H., Goudounèche, D., Cambillau, M., Kellner-Weibel, G., Robinet, P., Royer, L. J., MOATTI, N., Simon, A. C., et al. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.08.011 · Cited by 44 · see citing works
SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome
Yancey, P. G., Asztalos, B. F., Stettler, N., Piccoli, D. A., Williams, D. L., Connelly, M. A., & Rothblat, G. H. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400133-jlr200 · Cited by 37 · see citing works
Use of fluorescent cholesteryl ester microemulsions in cholesteryl ester transfer protein assays
Bisgaier, C. L., Minton, L. L., Essenburg, A., White, A. D., & Homan, R. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36955-8 · Cited by 37 · see citing works
Pape, M. E., Ulrich, R. G., Rea, T. J., Marotti, K. R., & Melchior, G. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98766-1 · Cited by 32 · see citing works
Flagged first, then by citations
1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Khoo, H. E., Azlan, A., Tang, S. T., & Lim, S. M. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1361779 · Cited by 2,988 · see citing works
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Mattioli, R., Francioso, A., Mosca, L., & Silva, P. (2020) · Molecules · doi:10.3390/molecules25173809 · Cited by 1,089 · see citing works
The Case for Anthocyanin Consumption to Promote Human Health: A Review
Pojer, E., Mattivi, F., Johnson, D., & Stockley, C. S. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12024 · Cited by 636 · see citing works
Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 608 · see citing works
Tena, N., Martı́n, J., & Asuero, A. G. (2020) · Antioxidants · doi:10.3390/antiox9050451 · Cited by 517 · see citing works
Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome
Basu, A., Du, M., Leyva, M. J., Sanchez, K., Betts, N. M., Wu, M., Aston, C. E., & Lyons, T. J. (2010) · Journal of Nutrition · doi:10.3945/jn.110.124701 · Cited by 507 · see citing works
Cassidy, A., Mukamal, K., Liu, L., Franz, M., Eliassen, A., & Rimm, E. (2013) · Circulation · doi:10.1161/circulationaha.112.122408 · Cited by 442 · see citing works
Berries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
Li, D., Zhang, Y., Liu, Y., Sun, R., & Xia, M. (2015) · Journal of Nutrition · doi:10.3945/jn.114.205674 · Cited by 373 · see citing works
Alvarez-Suarez, J. M., Giampieri, F., Tulipani, S., Casoli, T., Di Stefano, G., González-Paramás, A. M., Santos-Buelga, C., Busco, F., Quiles, J. L., Cordero, M. D., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.11.002 · Cited by 370 · see citing works
Strawberry and Human Health: Effects beyond Antioxidant Activity
Giampieri, F., Álvarez-Suárez, J. M., & Battino, M. A. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405455n · Cited by 357 · see citing works
Nutraceuticals and dyslipidaemia: Beyond the common therapeutics
Scicchitano, P., Cameli, M., Maiello, M. R., Modesti, P. A., Muiesan, M. L., Novo, S., Palmiero, P., Saba, P. S., Pedrinelli, R., & Ciccone, M. M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2013.12.006 · Cited by 351 · see citing works
Xiao, J., Kai, G., Yamamoto, K., & Chen, X. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.561379 · Cited by 340 · see citing works
A Review on Structure–Activity Relationship of Dietary Polyphenols Inhibiting α-Amylase
Xiao, J., Ni, X., Kai, G., & Chen, X. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.548108 · Cited by 327 · see citing works
Wang, D.-L., Xia, M., Yan, X.-D., Li, D., Wang, L., Xu, Y., Jin, T.-R., & Ling, W. (2012) · Circulation Research · doi:10.1161/circresaha.112.266502 · Cited by 291 · see citing works
Cranberries and Their Bioactive Constituents in Human Health
Blumberg, J. B., Camesano, T. A., Cassidy, A., Kris‐Etherton, P. M., Howell, A. B., Manach, C., Ostertag, L. M., Sies, H., Skulas‐Ray, A. C., & Vita, J. A. (2013) · Advances in Nutrition · doi:10.3945/an.113.004473 · Cited by 313 · see citing works
Strawberry As a Functional Food: An Evidence-Based Review
Basu, A., Nguyen, A., Betts, N. M., & Lyons, T. J. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.608174 · Cited by 312 · see citing works
Zhu, Y., Ling, W., Guo, H., Song, F., Ye, Q., Zou, T., Li, D., Zhang, Y., Li, G., Xiao, Y., et al. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.06.005 · Cited by 289 · see citing works
Akkarachiyasit, S., Charoenlertkul, P., Yibchok‐anun, S., & Adisakwattana, S. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11093387 · Cited by 258 · see citing works
Reis, J. F., Monteiro, V. S., Gomes, R. D. S., do Carmo, M. M., da Costa, G. V., Ribera, P. C., & Monteiro, M. C. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1076-5 · Cited by 265 · see citing works
Proanthocyanidins, anthocyanins and cardiovascular diseases
Kruger, M. J., Davies, N. H., Myburgh, K. H., & Lecour, S. (2014) · Food Research International · doi:10.1016/j.foodres.2014.01.046 · Cited by 250 · see citing works
Pleotropic Effects of Polyphenols in Cardiovascular System
Behl, T., BUNGAU, S. G., Kumar, K., Zengin, G., Khan, F., Kumar, A., Kaur, R., Venkatachalam, T., Ţiţ, D. M., Vesa, C. M., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110714 · Cited by 227 · see citing works
Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products
Wang, D., Yang, Y., Lei, Y., Tzvetkov, N. T., Liu, X., Yeung, A. W. K., Xu, S., & Atanasov, A. G. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.017178 · Cited by 223 · see citing works
Zhu, Y., Xia, M., Yang, Y., Liu, F., Li, Z., Hao, Y., Mi, M., Jin, T., & Ling, W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.167361 · Cited by 224 · see citing works
Guo, H., Xia, M., Zou, T., Ling, W., Zhong, R., & Zhang, W. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.12.013 · Cited by 221 · see citing works
Anthocyanins and Human Health—A Focus on Oxidative Stress, Inflammation and Disease
Speer, H., D'Cunha, N. M., Alexopoulos, N. I., McKune, A. J., & Naumovski, N. (2020) · Antioxidants · doi:10.3390/antiox9050366 · Cited by 213 · see citing works
Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis
Garcia, C., & Blesso, C. N. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.040 · Cited by 213 · see citing works
Systematic Review of Anthocyanins and Markers of Cardiovascular Disease
Wallace, T. C., Slavin, M., & Frankenfeld, C. L. (2016) · Nutrients · doi:10.3390/nu8010032 · Cited by 198 · see citing works
Advanced preservation methods and nutrient retention in fruits and vegetables
Barrett, D. M., & Lloyd, B. B. (2011) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4718 · Cited by 197 · see citing works
Berry (Poly)phenols and Cardiovascular Health
Rodriguez‐Mateos, A., Heiß, C., Borges, G., & Crozier, A. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf403757g · Cited by 195 · see citing works
Fruits for Prevention and Treatment of Cardiovascular Diseases
Zhao, C., Meng, X., Li, Y., Li, S., Liu, Q., Tang, G., & Li, H. (2017) · Nutrients · doi:10.3390/nu9060598 · Cited by 193 · see citing works
Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function
Millar, C. L., Duclos, Q., & Blesso, C. N. (2017) · Advances in Nutrition · doi:10.3945/an.116.014050 · Cited by 204 · see citing works
Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome
Basu, A., Fu, D. X., Wilkinson, M., Simmons, B. N., Wu, M., Betts, N. M., Du, M., & Lyons, T. J. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.06.016 · Cited by 184 · see citing works
Chan, S. M. H., Selemidis, S., Bozinovski, S., & Vlahos, R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.013 · Cited by 180 · see citing works
Effects and Mechanisms of Fruit and Vegetable Juices on Cardiovascular Diseases
Zheng, J., Zhou, Y., Li, S., Zhang, P., Zhou, T., Xu, D.-P., & Li, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030555 · Cited by 178 · see citing works
Wang, D., Wei, X., Xiao, Y., Jin, T., & Ling, W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103427j · Cited by 176 · see citing works
Phytonutrients as therapeutic agents
Gupta, C., & Prakash, D. (2014) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2013-0021 · Cited by 173 · see citing works
Role and classification of cholesterol-lowering functional foods
Chen, Z., Ma, K. Y., Liang, Y., Peng, C., & Zuo, Y. (2011) · Journal of Functional Foods · doi:10.1016/j.jff.2011.02.003 · Cited by 172 · see citing works
Yang, L., Ling, W., Du, Z., Chen, Y., Li, D., Deng, S., Liu, Z., & Yang, L. (2017) · Advances in Nutrition · doi:10.3945/an.116.014852 · Cited by 167 · see citing works
Dietary strategies implicated in the prevention and treatment of metabolic syndrome
De la Iglesia, R., Loria-Kohen, V., Zulet, M., Martinez, J., Reglero, G., & Ramirez de Molina, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111877 · Cited by 168 · see citing works
Pour, P. M., Fakhri, S., Asgary, S., Farzaei, M. H., & Echeverría, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01207 · Cited by 168 · see citing works
Functional foods as potential therapeutic options for metabolic syndrome
Brown, L., Poudyal, H., & Panchal, S. K. (2015) · Obesity Reviews · doi:10.1111/obr.12313 · Cited by 159 · see citing works
Guo, H., & Ling, W. (2015) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9302-z · Cited by 157 · see citing works
Huang, H., Chen, G., Liao, D., Zhu, Y., & Xue, X. (2016) · Scientific Reports · doi:10.1038/srep23625 · Cited by 149 · see citing works
Shi, M. Y., Loftus, H., McAinch, A. J., & Su, X. Q. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2016.12.036 · Cited by 148 · see citing works
García‐Conesa, M., Chambers, K., Combet, E., Pinto, P., Garcia‐Aloy, M., Andrés‐Lacueva, C., de Pascual‐Teresa, S., Mena, P. R., Konić‐Ristić, A., Hollands, W. J., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030694 · Cited by 144 · see citing works
Davinelli, S., Bertoglio, J. C., Zarrelli, A., Pina, R., & Scapagnini, G. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1080108 · Cited by 140 · see citing works
Hassellund, S. S., Flaa, A., Kjeldsen, S. E., Seljeflot, I., Karlsen, A. S., Erlund, I., & Rostrup, M. (2012) · Journal of Human Hypertension · doi:10.1038/jhh.2012.4 · Cited by 139 · see citing works
The genetic aspects of berries: from field to health
Mazzoni, L., Pérez-López, P., Giampieri, F., Álvarez-Suárez, J. M., Gasparrini, M., Forbes-Hernández, T. Y., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7216 · Cited by 139 · see citing works
Ilkun, O. L., & Boudina, S. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319270003 · Cited by 137 · see citing works
Basu, A., Betts, N. M., Nguyen, A., Newman, E. D., Fu, D., & Lyons, T. J. (2014) · Journal of Nutrition · doi:10.3945/jn.113.188169 · Cited by 134 · see citing works
Islam, S. U., Ahmed, M. B., Ahsan, H., & Lee, Y. S. (2021) · Antioxidants · doi:10.3390/antiox10050784 · Cited by 140 · see citing works
Tomé‐Carneiro, J., & Visioli, F. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.10.018 · Cited by 132 · see citing works
Zhu, Y., Huang, X., Zhang, Y., Wang, Y., Liu, Y., Sun, R., & Xia, M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2845 · Cited by 128 · see citing works
Howard, L. R., Prior, R. L., Liyanage, R., & Lay, J. O. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2046575 · Cited by 126 · see citing works
Functional Food and Cardiovascular Disease Prevention and Treatment: A Review
Asgary, S., Rastqar, A., & Keshvari, M. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1410867 · Cited by 132 · see citing works
Bilberry (Vaccinium myrtillus L.)
Chu, W.-K., Cheung, S. C. M., Lau, R. A. W., & Benzie, I. F. F. (2011) · Oxidative stress and disease · doi:10.1201/b10787-5 · Cited by 122 · see citing works
Bouyahya, A., Omari, N. E., Hachlafi, N. E., Jemli, M. E., Hakkour, M., Balahbib, A., Menyiy, N. E., Bakrim, S., Mrabti, H. N., Khouchlaa, A., et al. (2022) · Molecules · doi:10.3390/molecules27103286 · Cited by 122 · see citing works
Nutraceuticals and Functional Foods in the Management of Hyperlipidemia
Chen, G., Wang, H., Zhang, X., & Yang, S. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.629354 · Cited by 120 · see citing works
Zhang, P.-W., Chen, F.-X., Li, D., Ling, W.-H., & Guo, H.-H. (2015) · Medicine · doi:10.1097/md.0000000000000758 · Cited by 116 · see citing works
Self-citationDietary Flavonoids in the Prevention of T2D: An Overview
Alkhalidy, H., Wang, Y., & Liu, D. (2018) · Nutrients · doi:10.3390/nu10040438 · Cited by 117 · see citing works
Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome
Noce, A., Lauro, M. D., Daniele, F. D., Zaitseva, A. P., Marrone, G., Borboni, P., & Daniele, N. D. (2021) · Nutrients · doi:10.3390/nu13020630 · Cited by 116 · see citing works
Xie, L., Vance, T. M., Kim, B., Lee, S. G., Caceres, C., Wang, Y., Hubert, P. A., Lee, J., Chun, O. K., & Bolling, B. W. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.12.007 · Cited by 105 · see citing works
Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review
Naseri, R., Farzaei, F., Haratipour, P., Nabavi, S. F., Habtemariam, S., Farzaei, M. H., Khodarahmi, R., Tewari, D., & Momtaz, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01310 · Cited by 102 · see citing works
Bioactive compounds from herbal medicines to manage dyslipidemia
Ji, X., Shi, S., Liu, B., Shan, M., Tang, D., Zhang, W., Zhang, Y., Zhang, L., Zhang, H., Lu, C. C., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109338 · Cited by 104 · see citing works
Dietary flavonoid intake and cardiovascular risk: a population-based cohort study
Ponzo, V., Goitre, I., Fadda, M., Gambino, R., Francesco, A. D., Soldati, L., Gentile, L., Magistroni, P., Cassader, M., & Bo, S. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0573-2 · Cited by 111 · see citing works
Yang, Y., Shi, Z., Adili, R., Jin, J. W., Li, C., Wang, Y., Andrews, M. C., Chen, P., Zhu, G., Ling, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037323 · Cited by 99 · see citing works
Sozański, T., Kucharska, A., Rapak, A., Szumny, D., Trocha, M., Merwid-Ląd, A., Dzimira, S., Piasecki, T., Piórecki, N., Magdalan, J., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.10.001 · Cited by 88 · see citing works
Li, G., Zhu, Y., Zhang, Y., Jing, L., Chen, Y., & Ling, W. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.01.018 · Cited by 96 · see citing works
den Hil, E. F. H.-V., van Schothorst, E. M., van der Stelt, I., Swarts, H. J. M., Vliet, M., Amolo, T., Vervoort, J. J. M., Venema, D. P., Hollman, P. C. H., Rietjens, I. M. C. M., et al. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0469-z · Cited by 96 · see citing works
Guo, H., Liu, G., Zhong, R., Wang, Y., Wang, D., & Xia, M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-10 · Cited by 96 · see citing works
Zou, T., Feng, D., Song, G., Li, H.-W., Tang, H., & Ling, W. (2014) · Nutrients · doi:10.3390/nu6104165 · Cited by 92 · see citing works
Sozański, T., Kucharska, A. Z., Szumny, A. J., Magdalan, J., Bielska, K., Merwid‐Ląd, A., Woźniak-Biel, A., Dzimira, S., Piórecki, N., & Trocha, M. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.09.005 · Cited by 91 · see citing works
Ghaffari, S., & Roshanravan, N. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108749 · Cited by 91 · see citing works
Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet
Sun, X., Seeberger, J., Alberico, T., Wang, C., Wheeler, C. T., Schauss, A. G., & Zou, S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.008 · Cited by 90 · see citing works
Ockermann, P., Headley, L., Lizio, R., & Hansmann, J. (2021) · Nutrients · doi:10.3390/nu13082831 · Cited by 92 · see citing works
Zhang, B., Liu, R., He, F., Zhou, P., & Duan, C. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.08.026 · Cited by 89 · see citing works
Guo, H., Guo, J.-B., Jiang, X., Zhen, L., & Ling, W. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.06.015 · Cited by 87 · see citing works
Jia, Y., Kim, J. Y., Jun, H., Kim, S.-J., Lee, J.-H., Hoang, M. H., Kim, H. S., Chang, H. I., Hwang, K.-Y., Um, S., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.11.012 · Cited by 87 · see citing works
Chew, B. P., Mathison, B. D., Kimble, L. L., McKay, D. L., Kaspar, K. L., Khoo, C., Chen, C. O., & Blumberg, J. B. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1643-z · Cited by 87 · see citing works
Dietary berries, insulin resistance and type 2 diabetes: an overview of human feeding trials
Calvano, A., Izuora, K. E., Oh, E. C. T., Ebersole, J. L., Lyons, T. J., & Basu, A. (2019) · Food & Function · doi:10.1039/c9fo01426h · Cited by 88 · see citing works
Les, F., Cásedas, G., Rincón, C. G., Moliner, C., Valero, M. S., & López, V. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00739-z · Cited by 90 · see citing works
Wei, X., Wang, D., Yang, Y., Xia, M., Li, D., Li, G., Zhu, Y., Xiao, Y., & Ling, W. (2011) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4275 · Cited by 86 · see citing works
Xu, L., Tian, Z., Chen, H., Zhao, Y., & Yang, Y. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.747884 · Cited by 84 · see citing works
Yang, Y., Andrews, M. C., Hu, Y., Wang, D., Yu, Q., Zhu, Y., Ni, H., & Ling, W. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201079h · Cited by 84 · see citing works
Liu, C., Sun, J., Lu, Y., & Bo, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162089 · Cited by 83 · see citing works
Malaj, N., Simone, B. C. D., Quartarolo, A. D., & Russo, N. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.06.017 · Cited by 83 · see citing works
Wang, D., Zou, T., Yang, Y., Yan, X., & Ling, W. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.04.007 · Cited by 83 · see citing works
Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis
Soltani, S., Boozari, M., Cicero, A. F. G., Jamialahmadi, T., & Sahebkar, A. (2021) · Phytotherapy Research · doi:10.1002/ptr.6991 · Cited by 81 · see citing works
Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice
Qian, X., Wang, X., Luo, J., Liu, Y., Pang, J., Zhang, H., Xu, Z., Xie, J., Jiang, X., & Ling, W. (2019) · Food & Function · doi:10.1039/c8fo02124d · Cited by 80 · see citing works
Solverson, P. M., Rumpler, W. V., Leger, J., Redan, B. W., Ferruzzi, M. G., Baer, D. J., Castonguay, T. W., & Novotny, J. A. (2018) · Nutrients · doi:10.3390/nu10081048 · Cited by 76 · see citing works
Wang, Y., Chen, X., Huang, Z., Chen, D., Yu, B., Yu, J., Chen, H., He, J., Luo, Y., & Zheng, P. (2020) · Nutrients · doi:10.3390/nu12123811 · Cited by 75 · see citing works
Wright, O. R. L., Netzel, G. A., & Sakzewski, A. R. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0349 · Cited by 75 · see citing works
Fallah, A. A., Sarmast, E., & Jafari, T. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109379 · Cited by 74 · see citing works
Daneshzad, E., Shab‐Bidar, S., Mohammadpour, Z., & Djafarian, K. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.06.979 · Cited by 72 · see citing works
Thrombotic and cardiovascular risks in type two diabetes; Role of platelet hyperactivity
Gaiz, A. A., Mosawy, S., Colson, N., & Singh, I. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.121 · Cited by 72 · see citing works
Alqurashi, R. M., Galante, L., Rowland, I. R., Spencer, J. P. E., & Commane, D. M. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.128728 · Cited by 71 · see citing works
Akhlaghi, M., Ghobadi, S., Hosseini, M., Gholami, Z., & Mohammadian, F. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.04.001 · Cited by 71 · see citing works
Superfoods: Recent Data on their Role in the Prevention of Diseases
Proestos, C. (2018) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.6.3.02 · Cited by 70 · see citing works
- Authors
- Qin, Y., Xia, M., Ma, J., Hao, Y., Liu, J., Mou, H., Cao, L., & Ling, W.
- Corresponding author
- Ling, WenHua
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 90
- Issue
- 3
- Pages
- 485-492
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2153378467
- Cited by
- 443
- References
- 35
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 18 · 2023: 22 · 2022: 26 · 2021: 41 · 2020: 48 · 2019: 32 · 2018: 33 · 2017: 23 · 2016: 33 · 2015: 20 · 2014: 27 · 2013: 35 · 2012: 20
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- anthocyanins, dyslipidemia, LDL cholesterol, HDL cholesterol, cholesteryl ester transfer protein, CETP inhibition, cholesterol efflux, lipid profile, cyanidin-3-glucoside, HepG2 cells
- MeSH terms
- Adult, Aged, Anthocyanins, Biological Transport, Cell Line, Dose-Response Relationship, Drug, Double-Blind Method, Female, Fruit, Glucosides, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Phytotherapy, Middle Aged, Plant Extracts, Dietary Supplements, Dyslipidemias, Cholesterol Ester Transfer Proteins
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