CoChat
Sign Up
Cited by 119Protein Kinase Regulation and GTPase SignalingCell Adhesion Molecules ResearchGene Regulatory Network Analysis

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Integrin-mediated signalling through the MAP-kinase pathway

Open access
Yee, K.L., Weaver, V.M., Hammer, D.A.·2008·IET Systems Biology
DOI 10.1049/iet-syb:20060058
Open this paper in CoChat — free accountOpen PDF

Abstract

The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK are mediated by differences in ERK signalling dynamics, including magnitude and duration. In vivo, ERK signalling is stimulated by both growth factors and adhesion signals. A model for adhesion-mediated ERK activation is presented. Outputs of the model such as ERK and FAK activation, as well as responses to different ligand densities, are compared with published experimental data. The model then serves as a basis for understanding how adhesion may contribute to ERK signalling through changes in the dynamics of focal adhesion kinase activation. The main parameters influencing ERK are determined through screening analyses and parameter variation. With these parameters, key points in the pathway that give rise to changes in downstream signalling dynamics are identified. In particular, oncogenic Raf and Ras promote cell growth by increasing the magnitude and duration, respectively, of ERK activity.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1049/iet-syb:20060058

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The MAPK/ERK cascade is a key regulator of cell growth and proliferation, and this signaling pathway activates the binding of different integrins at the cell surface to extracellular matrix proteins.

    “The MAPK/ERK cascade is a key regulator of cell growth and proliferation, but most important, this signaling pathway activates the binding of different integrins at the cell surface to extracellular matrix proteins [60], linking its function with the up-regulated integrin pathway explained above.”

    From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [60]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 45

  1. Hanahan, 2000, 100, 57
  2. Aplin, 2001, 155, 187
  3. Shaulian, 2001, 20, 2390
  4. Marshall, 1999, 11, 732
  5. Roovers, 2000, 22, 818
  6. Danen, 2001, 189, 1
  7. Renshaw, 1997, 16, 5592
  8. Barberis, 2000, 275, 36532
  9. Schlaepfer, 1998, 8, 151
  10. Wary, 1996, 87, 733
  11. Assoian, 2001, 11, 48
  12. Giancotti, 1997, 9, 691
  13. Schwartz, 2002, 4, E65
  14. Roovers, 1999, 10, 3197
  15. Kholodenko, 1999, 274, 30169
  16. Schoeberl, 2002, 20, 370
  17. Chapman, 2004, 85, 311
  18. Hornberg, 2005, 24, 5533
  19. Asthagiri, 1999, 274, 27119
  20. Giannone, 2004, 116, 431
  21. Parsons, 2003, 116, 1409
  22. Aplin, 1998, 50, 197
  23. Kaplan, 1994, 13, 4745
  24. Bjorge, 2000, 19, 5620
  25. Boerner, 1996, 35, 9519
  26. Cole, 1994, 269, 30880
  27. Schlaepfer, 1997, 272, 13189
  28. Schlaepfer, 1998, 18, 2571
  29. Downward, 1994, 338, 113
  30. Howe, 1998, 273, 27268
  31. Wary, 1998, 94, 625
  32. Kaneko, 2003, 278, 48162
  33. Matsuda, 1996, 271, 14468
  34. Fincham, 1996, 135, 1551
  35. Wang, 2002, 277, 40428
  36. Wang, 1997, 36, 2993
  37. Zhang, 1995, 270, 11199
  38. Sydor, 1998, 37, 14292
  39. Hecker, 2004, 23, 3962
  40. Sharma, 1998, 17, 271
  41. Sewing, 1997, 17, 5588
  42. Woods, 1997, 17, 5598
  43. Dougherty, 2005, 17, 215
  44. Sundberg-Smith, 2005, 280, 2055
  45. Brummer, 2003, 22, 8823

Cited by

Sorted by citations

Related

Metadata

Authors
Yee, K. L., Weaver, V. M., & Hammer, D. A.
Affiliations
  • University of Pennsylvania (US)
  • University of California, San Francisco (US)
ORCID
Venue
IET Systems Biology
Publisher
Institution of Engineering and Technology (IET)
Published
2008-01-21
Volume
2
Issue
1
Pages
8-15
ISSN
  • 1751-8849 (ISSN-L)
  • 1751-8857
DOI
10.1049/iet-syb:20060058
OpenAlex
W2023251706
Cited by
117
References
51
Citations by year
2026: 6 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 4 · 2012: 6
FWCI
0.82
Type
journal article
Language
en
Open access
Locations
  • IET Systems Biology (publishedVersion)
  • PubMed (publishedVersion)
  • ScholarlyCommons (University of Pennsylvania) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
integrin signaling, MAP kinase cascade, ERK activation, focal adhesion kinase, ligand density, oncogenic Ras, cell growth and proliferation
MeSH terms
Animals, Humans, Models, Biological, Integrins, ras Proteins, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review