The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
Open accessAbstract
Increased intestinal permeability to several specific molecular probes has been observed in patients with Crohn's disease and their first-degree relatives. A positive family history is also a potent risk factor for inflammatory bowel disease. Although it has been argued that increased permeability in relatives may confer an increased future risk of developing Crohn's disease, long-term follow-up of such family members has been lacking. We describe a 24-year-old woman with a positive family history of Crohn's disease who had an elevated gut permeability to (51)Cr-EDTA at age 13, as part of a cross-sectional cohort study in patients and their first-degree relatives. She was asymptomatic at the time, and extensive investigation found no evidence of microscopic or macroscopic Crohn's disease. Repeat investigation because of symptom onset at age 21 revealed ileocolonic Crohn's disease, which required treatment with systemic corticosteroids to induce a clinical remission. In this case, a permeability defect was clearly identified to precede the onset of Crohn's disease in a subject at increased risk. This observation provides support for the hypothesis that increased gut permeability to macromolecules is an early step in the pathogenesis of this disorder.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A case study of a 24-year-old woman with a positive family history of Crohn’s disease showed an increased intestinal permeability precedes the onset of Crohn’s disease [182].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [182]
Citations
Cites
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927
D’Haens, G., Geboes, K., Peeters, M., Baert, F., PENNINCKX, F. M., & Rutgeerts, P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70476-7 · Cited by 866
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives
Hollander, D., Vadheim, C. M., Brettholz, E., Petersen, G. M., Delahunty, T., & Rotter, J. I. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-883 · Cited by 762
Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
Rutgeerts, P., Peeters, M., Hiele, M. I., Vantrappen, G. R., Pennincx, F., Aerts, R., Kerremans, R., & Goboes, K. (1991) · The Lancet · doi:10.1016/0140-6736(91)90663-a · Cited by 758
Familial Occurrence of Inflammatory Bowel Disease
Orholm, M. K., Munkholm, P. S., Langholz, E., Nielsen, O. H., Sørensen, T. I. A., & Binder, V. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101103240203 · Cited by 685
Intestinal permeability and the prediction of relapse in Crohn's disease
Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626
Parenteral Nutrition Is Associated With Intestinal Morphologic and Functional Changes in Humans
Buchman, A. L., Moukarzel, A. A., Bhuta, S. M., Belle, M., Ament, M. E., Eckhert, C. D., Hollander, D., Gornbeln, J., Kopple, J. D., & Vijayaroghavan, S. R. (1995) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607195019006453 · Cited by 410
Madsen, K. L., Malfair, D., Gray, D., Doyle, J. S. G., Jewell, L. D., & Fedorak, R. N. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199911000-00004 · Cited by 318
Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
May, G. R., Sutherland, L. R., & Meddings, J. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90638-s · Cited by 316
Intestinal permeability in patients with Crohn's disease and their healthy relatives
Katz, K. D., Hollander, D., Vadheim, C. M., McElree, C. K., Delahunty, T., Dadufalza, V. D., Krugliak, P., & Rotter, J. I. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91499-6 · Cited by 302
Clustering of increased small intestinal permeability in families with Crohn's disease
Peeters, M., Geypens, B. J., Claus, D., Nevens, H., Ghoos, Y. F., Verbeke, G. N., Baert, F., Vermeire, S., VLIETINCK, R. F., & Rutgeerts, P. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70174-4 · Cited by 262
Söderholm, J. D., Olaison, G., Lindberg, E., Hannestad, U., Vindels, A., Tysk, C., Järnerot, G., & Sjödahl, R. I. (1999) · Gut · doi:10.1136/gut.44.1.96 · Cited by 206
Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?
Söderholm, J. D., Peterson, K. H., Olaison, G., Franzén, L., Weström, B. R., Magnusson, K., & Sjödahl, R. I. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70551-2 · Cited by 201
Intestinal permeability in patients with Crohn's disease and their first degree relatives.
Teahon, K., Smethurst, P., Levi, A. J., Menzies, I. S., & Bjarnason, I. (1992) · Gut · doi:10.1136/gut.33.3.320 · Cited by 195
Hilsden, R. J., Meddings, J., & Sutherland, L. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613043 · Cited by 169
Orholm, M. K., Fonager, K., & Sørensen, H. T. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01526.x · Cited by 132
Permeability in Crohn's disease: Altered barrier functions in healthy relatives?
Hollander, D. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90668-3 · Cited by 115
Effect of daily ethanol ingestion on intestinal permeability to macromolecules
Worthington, B. S., Meserole, L., & Syrotuck, J. A. (1978) · Digestive Diseases and Sciences · doi:10.1007/bf01072571 · Cited by 105
Review article: Intestinal permeability in Crohn's disease
Meddings, J. B. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1997.tb00808.x · Cited by 98
Rt, J., Ramage, J. K., Jones, D. B., Collins, S. M., Goodacre, R. L., & Hunt, R. H. (1988) · PubMed · Cited by 93
The prevalence of inflammatory bowel disease in relatives of patients with Crohn's disease
Satsangi, J., Rosenberg, W. M., & Jewell, D. P. (1994) · UCL Discovery (University College London) · Cited by 88
Intestinal permeability in Crohn's disease.
Murphy, M., EASTHAM, E. J., NELSON, R. L., Pearson, A., & Laker, M. F. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.3.321 · Cited by 76
Miki, K., Moore, D., Butler, R. N., Southcott, E., Couper, R. T. L., & Davidson, G. P. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70145-3 · Cited by 70
Barau, E., & Dupont, C. M. (1990) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199007000-00015 · Cited by 64
Hilsden, R. J., Meddings, J. B., Hardin, J. W., Gall, G. D., & Sutherland, L. R. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199905000-00003 · Cited by 55
Noyer, C. M., Simon, D. M., Borczuk, A., Brandt, L. J., Lee, M. J., & Nehra, V. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00290.x · Cited by 50
Krugliak, P., Hollander, D., Le, K., Ma, T., Dadufalza, V. D., & Katz, K. D. (1990) · Gut · doi:10.1136/gut.31.4.417 · Cited by 42
Intestinal Permeability before and after Ibuprofen in Families of Children with Crohn’s Disease
Zamora, S. A., Hilsden, R. J., Meddings, J. B., Butzner, J. D., Scott, R. B., & Sutherland, L. R. (1999) · Canadian Journal of Gastroenterology · doi:10.1155/1999/457315 · Cited by 37
Assessing the site of increased intestinal permeability in coeliac and inflammatory bowel disease.
Teahon, K., Somasundaram, S. G., Smith, T., Menzies, I. S., & Bjarnason, I. (1996) · Gut · doi:10.1136/gut.38.6.864 · Cited by 29
Intestinal Permeability to Polyethylene Glycols in Monozygotic Twins with Crohn's Disease
Lindberg, E., Söderholm, J. D., Olaison, G., Tysk, C., & Järnerot, G. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509096327 · Cited by 20
Flagged first, then by citations
Research works printed but not linked: 1
- Ramage, 1988, Effects of immunologic reactions on rat intestinal epithelium: correlation of increased intestinal permeability to 51Cr-labeled EDTA and ovalbumin during acute inflammation and anaphylaxis, Gastroen-terology, 94, 1268
Cited by
Sorted by citations
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Inflammatory bowel disease: cause and immunobiology
Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775
The intestinal barrier: a fundamental role in health and disease
Vancamelbeke, M., & Vermeire, S. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1343143 · Cited by 1,388
Metadata
- Authors
- Irvine, E. J., & Marshall, J. K.
- Affiliations
- McMaster University (CA)
- ORCID
- Marshall, John K.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 119
- Issue
- 6
- Pages
- 1740-1744
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2061791452
- Cited by
- 286
- References
- 30
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 13 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 3 · 2017: 15 · 2016: 4 · 2015: 15 · 2014: 12 · 2013: 17 · 2012: 12
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Crohn's disease, intestinal permeability, familial risk, first-degree relatives, 51Cr-EDTA, ileocolonic Crohn's disease, inflammatory bowel disease, disease onset, pathogenesis, systemic corticosteroids, remission
- MeSH terms
- Adolescent, Adult, Crohn Disease, Cross-Sectional Studies, Edetic Acid, Female, Humans, Intestinal Mucosa, Male, Permeability, Cohort Studies, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
