Cited by 233Iron Metabolism and DisordersLiver Disease Diagnosis and TreatmentTrace Elements in Health

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Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease

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Facchini, Francesco S., Hua, Nancy W., Stoohs, Riccardo A.·2002·Gastroenterology

DOI 10.1053/gast.2002.32403

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Abstract

Background & aims Increased body iron, genetic hemochromatosis (GH) mutations, and nonalcoholic fatty liver disease (NAFLD) tend to cluster in carbohydrate-intolerant patients. In an attempt to further clarify the interrelationships among these conditions, we studied 42 carbohydrate-intolerant patients who were free of the common GH mutations C282Y and H63D, and had a serum iron saturation lower than 50%.Methods We measured body iron stores, and induced iron depletion to a level of near-iron deficiency (NID) by quantitative phlebotomy.Results In the 17 patients with clinical evidence of NAFLD, we could not demonstrate supranormal levels of body iron (1.6 +/- 0.2 vs. 1.4 +/- 0.2 g; P = 0.06). However, at NID, there was a 40%-55% improvement (P = 0.05-0.0001) of both fasting and glucose-stimulated plasma insulin concentrations, and near-normalization of serum alanine aminotransferase activity (from 61 +/- 5 to 32 +/- 2 IU/L; P < 0.001).Conclusions These results reflect the insulin-sparing effect of iron depletion and indicate a key role of iron and hyperinsulinemia in the pathogenesis of NAFLD.

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Authors: Facchini, F. S., Hua, N. W., & Stoohs, R. A.
Affiliations: San Francisco General Hospital (US)
Stanford Medicine (US)
ORCID: Stoohs, Riccardo A.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2002-04
Volume: 122
Issue: 4
Pages: 931-939
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/gast.2002.32403
OpenAlex: W2135385594
Cited by: 233
References: 53
Citations by year: 2026: 5 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 13 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 11 · 2012: 11
FWCI: 8.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Kaiser Permanente
Kaiser Foundation Research Institute
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: non-alcoholic fatty liver disease, iron depletion, carbohydrate intolerance, iron deficiency, iron stores, insulin resistance, hyperinsulinemia, insulin-sparing effect, alanine aminotransferase, hereditary hemochromatosis
MeSH terms: Adult, Alanine Transaminase, Blood Glucose, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Fatty Liver, Female, Hemochromatosis, Humans, Hyperinsulinism, Insulin, Iron, Male, Middle Aged, Phlebotomy

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Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease

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