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Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease

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Facchini, Francesco S., Hua, Nancy W., Stoohs, Riccardo A.·2002·Gastroenterology

DOI 10.1053/gast.2002.32403

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Abstract

Background & aims Increased body iron, genetic hemochromatosis (GH) mutations, and nonalcoholic fatty liver disease (NAFLD) tend to cluster in carbohydrate-intolerant patients. In an attempt to further clarify the interrelationships among these conditions, we studied 42 carbohydrate-intolerant patients who were free of the common GH mutations C282Y and H63D, and had a serum iron saturation lower than 50%.Methods We measured body iron stores, and induced iron depletion to a level of near-iron deficiency (NID) by quantitative phlebotomy.Results In the 17 patients with clinical evidence of NAFLD, we could not demonstrate supranormal levels of body iron (1.6 +/- 0.2 vs. 1.4 +/- 0.2 g; P = 0.06). However, at NID, there was a 40%-55% improvement (P = 0.05-0.0001) of both fasting and glucose-stimulated plasma insulin concentrations, and near-normalization of serum alanine aminotransferase activity (from 61 +/- 5 to 32 +/- 2 IU/L; P < 0.001).Conclusions These results reflect the insulin-sparing effect of iron depletion and indicate a key role of iron and hyperinsulinemia in the pathogenesis of NAFLD.

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345
Immunoassay of insulin with insulin-antibody precipitate
Hales, C. N., & Pj, R. (1963) · Biochemical Journal · doi:10.1042/bj0880137 · Cited by 2,640
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Association of nonalcoholic fatty liver disease with insulin resistance
Marchesini, G., Brizi, M., Morselli‐Labate, A. M., Bianchi, G. P., Bugianesi, E., McCullough, A. J., Forlani, G., & Melchionda, N. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00271-5 · Cited by 1,570
Regulation of hepatic fatty acid oxidation and ketone body production
McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460
Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors.
Wanless, I. R., & Lentz, J. S. (1990) · Hepatology · doi:10.1002/hep.1840120505 · Cited by 1,191
Nonalcoholic steatohepatitis: An expanded clinical entity
Bacon, B. R., Farahvash, M. J., Janney, C. G., & Neuschwander‐Tetri, B. A. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90235-6 · Cited by 1,137
Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine)
Carter, P. M. (1971) · Analytical Biochemistry · doi:10.1016/0003-2697(71)90405-2 · Cited by 787

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Bergmeyer, 1986, IFCC method for alanine and aspartate aminotransferase, J Clin Chem Clin Biochem, 24, 481

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Metabolic and hepatic effects of bloodletting in dysmetabolic iron overload syndrome: A randomized controlled study in 274 patients
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Phase II clinical trial of phlebotomy for non‐alcoholic fatty liver disease
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Nonalcoholic Fatty Liver Disease and Obesity
Saadeh, S. N. (2007) · Nutrition in Clinical Practice · doi:10.1177/011542650702200101 · Cited by 66
Pathological features of NASH.
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Systematic review and meta‐analysis to determine the impact of iron depletion in dysmetabolic iron overload syndrome and non‐alcoholic fatty liver disease
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Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI
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Authors: Facchini, F. S., Hua, N. W., & Stoohs, R. A.
Affiliations: San Francisco General Hospital (US)
Stanford Medicine (US)
ORCID: Stoohs, Riccardo A.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2002-04
Volume: 122
Issue: 4
Pages: 931-939
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/gast.2002.32403
OpenAlex: W2135385594
Cited by: 233
References: 53
Citations by year: 2026: 5 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 13 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 11 · 2012: 11
FWCI: 8.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Kaiser Permanente
Kaiser Foundation Research Institute
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: non-alcoholic fatty liver disease, iron depletion, carbohydrate intolerance, iron deficiency, iron stores, insulin resistance, hyperinsulinemia, insulin-sparing effect, alanine aminotransferase, hereditary hemochromatosis
MeSH terms: Adult, Alanine Transaminase, Blood Glucose, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Fatty Liver, Female, Hemochromatosis, Humans, Hyperinsulinism, Insulin, Iron, Male, Middle Aged, Phlebotomy

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Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease

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