The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis
Open accessAbstract
Deranged intestinal motility, which occurs in cirrhosis, may facilitate the development of intestinal bacterial overgrowth (IBO), which can lead to bacterial translocation (BT). To assess the effect of cisapride on IBO and BT in cirrhosis, cirrhotic rats received cisapride or a placebo for 7 days, and measurements of jejunal bacterial content and BT studies were performed. In addition, jejunal fluid from 46 cirrhotic patients was obtained for quantitative bacterial culture. Those patients in whom gram-negative IBO was detected were randomized to receive or not to receive cisapride (20 mg twice per day) for 1 week. Cisapride significantly reduced IBO in cirrhotic rats. In addition, no BT was documented in treated animals, whereas it occurred in 40% in nontreated cirrhotic rats. Total IBO was documented in 23 of 46 cirrhotic patients, which was caused by gram-negative organisms in 10 cases. Orocecal transit time (OCT) significantly decreased after cisapride therapy, and was associated with the abolishment of bacterial overgrowth caused by gram-negative organisms in 4 out of 5 treated patients, whereas it persisted in nontreated cases. Cisapride administration to cirrhotic rats resulted in a reduction of the IBO, which is associated with a marked decrease in BT. On the other hand, cisapride facilitates the abolition of IBO caused by gram-negative organisms in cirrhotic patients.
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“The prokinetic drug cisapride not only decreases intestinal transit time but also inhibits intestinal bacterial overgrowth and bacterial translocation, both in animal models150,151 and in patients with cirrhosis150,152.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [150]
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Cited by
Sorted by citations
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013
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Pathological bacterial translocation in liver cirrhosis
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Bacterial translocation (BT) in cirrhosis†
Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677
The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634
Metadata
- Authors
- Pardo, A., Bartolí, R., Lorenzo-Zúñiga, V., Planas, R., Viñado, B., Riba, J., Cabré, E., Santos, J., Luque, T., Ausina, V., & Gassull, M. A.
- Affiliations
- Hospital Universitari Germans Trias i Pujol (ES)
- Venue
- Hepatology
- Published
- 2000-04
- Volume
- 31
- Issue
- 4
- Pages
- 858-863
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2013027212
- Cited by
- 177
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 2 · 2012: 7
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Gastroenterological Association
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- cisapride, intestinal bacterial overgrowth, bacterial translocation, liver cirrhosis, intestinal motility, Gram-negative bacteria, orocecal transit time
- MeSH terms
- Adolescent, Adult, Aged, Animals, Bacteria, Female, Gastrointestinal Agents, Humans, Intestines, Liver Cirrhosis, Liver Cirrhosis, Experimental, Male, Middle Aged, Pilot Projects, Rats, Sprague-Dawley, Bacterial Translocation, Cisapride, Rats
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