The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Aging Kidney: Physiological Changes
Open accessAbstract
Age-associated loss of kidney function has been recognized for decades. With aging, many subjects exhibit progressive decreases in glomerular filtration rate (GFR) and renal blood flow (RBF), with wide variability among individuals. The fall in GFR is due to reductions in the glomerular capillary plasma flow rate, and the glomerular capillary ultrafiltration coefficient. In addition, a primary reduction in afferent arteriolar resistance is associated with an increase in glomerular capillary hydraulic pressure. These hemodynamic changes occur in concert with structural changes, including loss of renal mass; hyalinization of afferent arterioles and in some cases, development of aglomerular arterioles; an increase in the percentage of sclerotic glomeruli; and tubulointerstitial fibrosis. Aging is associated with altered activity and responsiveness to vasoactive stimuli, such that responses to vasoconstrictor stimuli are enhanced, while vasodilatory responses are impaired. Changes in the activity of the renin-angiotensin and nitric oxide systems appear to be particularly important, as is the modulating effect of gender. These changes may predispose the older kidney to acute kidney injury, including normotensive ischemic nephropathy, as well as progressive chronic kidney disease.
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Cites
Prevalence of Chronic Kidney Disease in the United States
Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P., Van Lente, F., & Levey, A. S. (2007) · JAMA · doi:10.1001/jama.298.17.2038 · Cited by 4,895
Predictors of New-Onset Kidney Disease in a Community-Based Population
Fox, C. S. (2004) · JAMA · doi:10.1001/jama.291.7.844 · Cited by 1,241 · cited 1×
“Epidemiologic studies suggest that acceleration of age-related loss of renal function may be associated with systemic hypertension (7,8), lead exposure (9), smoking (8,10), dyslipidemia (8), atherosclerotic disease (10), presence of inflammatory markers (11,12), increased levels of advanced glycosylation endproducts (…”
BackgroundEffects of renin–angiotensin system blockade in the aging kidney
Ferder, L. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00264-4 · Cited by 52
Cited by
Levey, A. S., & Coresh, J. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60178-5 · Cited by 1,841
Molecular mechanisms of renal aging
Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235
The aging kidney: increased susceptibility to nephrotoxicity
Wang, X., Bonventre, J., & Parrish, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915358 · Cited by 132
Tondo, L., Abramowicz, M., Alda, M., Bauer, M., Bocchetta, A., Bolzani, L., Calkin, C. V., Chillotti, C., Hidalgo-Mazzei, D., Manchia, M., et al. (2017) · International Journal of Bipolar Disorders · doi:10.1186/s40345-017-0096-2 · Cited by 125
The renin-angiotensin system and aging in the kidney
Yoon, H. E., & Choi, B. S. (2014) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2014.29.3.291 · Cited by 95
Metadata
- Authors
- Weinstein, J. R., & Anderson, S.
- Venue
- Advances in Chronic Kidney Disease
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 17
- Issue
- 4
- Pages
- 302-307
- ISSN
- 1548-5595 (ISSN-L)
- OpenAlex
- W2140577591
- Cited by
- 639
- References
- 3
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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